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Cardiovascular syphilis

MedGen UID:
21055
•Concept ID:
C0039130
•
Disease or Syndrome
Synonyms: Cardiovascular Syphilis; Syphilis, Cardiovascular
SNOMED CT: Cardiovascular syphilis (83883001)
 
Monarch Initiative: MONDO:0004911

Definition

Complications of syphilis seen in the cardiovascular system. These may include aortitis, aortic valve insufficiency with regurgitation, coronary artery stenosis, aortic root aneurysm and mucinous myocarditis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiovascular syphilis

Professional guidelines

PubMed

Management of Adult Syphilis: Key Questions to Inform the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines.
Ghanem KG
Clin Infect Dis 2015 Dec 15;61 Suppl 8:S818-36. doi: 10.1093/cid/civ714. PMID: 26602620
Treatment of cardiovascular syphilis.
St John RK
J Am Vener Dis Assoc 1976 Dec;3(2 Pt 2):148-52. PMID: 1010781
MANAGEMENT OF PATIENTS WITH ATRIAL FIBRILLATION.
HURST JW, PAULK EA Jr, PROCTOR HD, SCHLANT RC
Am J Med 1964 Nov;37:728-41. doi: 10.1016/0002-9343(64)90021-x. PMID: 14237428

Recent clinical studies

Etiology

Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017.
Landry T, Smyczek P, Cooper R, Gratrix J, Bertholet L, Read R, Romanowski B, Singh AE
BMJ Open 2019 Jun 22;9(6):e025995. doi: 10.1136/bmjopen-2018-025995. PMID: 31230001Free PMC Article
Classical syphilitic lesions from the museum.
Byard RW
Forensic Sci Med Pathol 2019 Jun;15(2):309-313. Epub 2018 Aug 7 doi: 10.1007/s12024-018-0012-9. PMID: 30083909
Syphilitic aortic aneurysm.
Yuan SM
Z Rheumatol 2018 Oct;77(8):741-748. doi: 10.1007/s00393-018-0519-1. PMID: 30073493
Cardiovascular syphilis: down but not out!
Dang G, Saleh M, Tandon T, Sirineni G, Alla VM
Eur Heart J Cardiovasc Imaging 2018 Jun 1;19(6):1. doi: 10.1093/ehjci/jey052. PMID: 29608710
Syphilitic aortitis and its complications in the modern era.
Drago F, Merlo G, Rebora A, Parodi A
G Ital Dermatol Venereol 2018 Oct;153(5):698-706. Epub 2016 Dec 16 doi: 10.23736/S0392-0488.16.05522-X. PMID: 27982548

Diagnosis

Syphilitic Aortitis.
Miller SA, Ladich ER
N Engl J Med 2022 May 19;386(20):e55. Epub 2022 May 14 doi: 10.1056/NEJMicm2110835. PMID: 35550616
Aortitis Presenting as Fever of Unknown Origin.
Yuan SM, Lin H
Ann Thorac Cardiovasc Surg 2018 Dec 20;24(6):279-287. Epub 2018 Aug 29 doi: 10.5761/atcs.ra.18-00136. PMID: 30158332Free PMC Article
Syphilitic aortic aneurysm.
Yuan SM
Z Rheumatol 2018 Oct;77(8):741-748. doi: 10.1007/s00393-018-0519-1. PMID: 30073493
Syphilis.
Crissey JT, Denenholz DA
Clin Dermatol 1984 Jan-Mar;2(1):1-166. doi: 10.1016/0738-081x(84)90003-8. PMID: 6400314
ATHEROMATOUS EMBOLISM.
ELIOT RS, KANJUH VI, EDWARDS JE
Circulation 1964 Oct;30:611-8. doi: 10.1161/01.cir.30.4.611. PMID: 14211824

Therapy

Cardiovascular syphilis: down but not out!
Dang G, Saleh M, Tandon T, Sirineni G, Alla VM
Eur Heart J Cardiovasc Imaging 2018 Jun 1;19(6):1. doi: 10.1093/ehjci/jey052. PMID: 29608710
Syphilitic aneurysm.
Gowland PA, Musleh G, Koukis I, McLaughlin KE
Int J STD AIDS 2010 Mar;21(3):222-3. Epub 2010 Jan 13 doi: 10.1258/ijsa.2009.009436. PMID: 20071445
Syphilis and otolaryngology.
Pletcher SD, Cheung SW
Otolaryngol Clin North Am 2003 Aug;36(4):595-605, vi. doi: 10.1016/s0030-6665(03)00025-2. PMID: 14567055
Syphilis management and treatment.
van Voorst Vader PC
Dermatol Clin 1998 Oct;16(4):699-711, xi. doi: 10.1016/s0733-8635(05)70035-8. PMID: 9891669
Syphilis.
Crissey JT, Denenholz DA
Clin Dermatol 1984 Jan-Mar;2(1):1-166. doi: 10.1016/0738-081x(84)90003-8. PMID: 6400314

Prognosis

Trends in Deaths Due to Syphilis, United States, 1968-2015.
Peterman TA, Kidd SE
Sex Transm Dis 2019 Jan;46(1):37-40. doi: 10.1097/OLQ.0000000000000899. PMID: 30044338Free PMC Article
Aortitis Presenting as Fever of Unknown Origin.
Yuan SM, Lin H
Ann Thorac Cardiovasc Surg 2018 Dec 20;24(6):279-287. Epub 2018 Aug 29 doi: 10.5761/atcs.ra.18-00136. PMID: 30158332Free PMC Article
Cardiovascular syphilis: down but not out!
Dang G, Saleh M, Tandon T, Sirineni G, Alla VM
Eur Heart J Cardiovasc Imaging 2018 Jun 1;19(6):1. doi: 10.1093/ehjci/jey052. PMID: 29608710
Controversies regarding giant cell (temporal, cranial) arteritis.
Eshaghian J
Doc Ophthalmol 1979 Sep 17;47(1):43-67. doi: 10.1007/BF00145369. PMID: 391520
Current status of the treatment of syphilis.
Barrett-Connor E
West J Med 1975 Jan;122(1):7-11. PMID: 1089007Free PMC Article

Clinical prediction guides

Combined Cardiovascular Syphilis and Type A Acute Aortic Dissection.
Roberts WC, Roberts CS
Am J Cardiol 2022 Apr 1;168:159-162. Epub 2022 Feb 1 doi: 10.1016/j.amjcard.2021.10.040. PMID: 35115135
Peripheral blood mononuclear cell microRNA profiles in syphilitic patients with serofast status.
Jia X, Wang Z, Liu X, Zheng H, Li J
Mol Biol Rep 2020 May;47(5):3407-3421. Epub 2020 Apr 24 doi: 10.1007/s11033-020-05421-7. PMID: 32333247
Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017.
Landry T, Smyczek P, Cooper R, Gratrix J, Bertholet L, Read R, Romanowski B, Singh AE
BMJ Open 2019 Jun 22;9(6):e025995. doi: 10.1136/bmjopen-2018-025995. PMID: 31230001Free PMC Article
Aortitis Presenting as Fever of Unknown Origin.
Yuan SM, Lin H
Ann Thorac Cardiovasc Surg 2018 Dec 20;24(6):279-287. Epub 2018 Aug 29 doi: 10.5761/atcs.ra.18-00136. PMID: 30158332Free PMC Article
Syphilitic Aortitis Diagnosis in Clinical Setting.
Fernandes B, Santos A, Carvalho L
Rev Port Cir Cardiotorac Vasc 2017 Jul-Dec;24(3-4):166. PMID: 29701397

Supplemental Content

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