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Surgical site infection

MedGen UID:
21034
Concept ID:
C0038941
Pathologic Function
Synonyms: Infection, Postoperative Wound; Infection, Surgical Site; Infection, Surgical Wound; Infections, Postoperative Wound; Infections, Surgical Site; Infections, Surgical Wound; Postoperative Wound Infection; Postoperative Wound Infections; Surgical Site Infection; Surgical Site Infections; Surgical Wound Infection; Surgical Wound Infections; Wound Infection, Postoperative; Wound Infection, Surgical; Wound Infections, Postoperative; Wound Infections, Surgical
SNOMED CT: Surgical site infection (433202001); Postoperative wound infection (58126003); Infected surgical wound (58126003)

Definition

Infection of a surgical skin incision. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSurgical site infection

Professional guidelines

PubMed

Obstet Gynecol 2018 Jun;131(6):e172-e189. doi: 10.1097/AOG.0000000000002670. PMID: 29794678
Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, Reinke CE, Morgan S, Solomkin JS, Mazuski JE, Dellinger EP, Itani KMF, Berbari EF, Segreti J, Parvizi J, Blanchard J, Allen G, Kluytmans JAJW, Donlan R, Schecter WP; Healthcare Infection Control Practices Advisory Committee
JAMA Surg 2017 Aug 1;152(8):784-791. doi: 10.1001/jamasurg.2017.0904. PMID: 28467526
Ban KA, Minei JP, Laronga C, Harbrecht BG, Jensen EH, Fry DE, Itani KM, Dellinger EP, Ko CY, Duane TM
J Am Coll Surg 2017 Jan;224(1):59-74. Epub 2016 Nov 30 doi: 10.1016/j.jamcollsurg.2016.10.029. PMID: 27915053

Recent clinical studies

Etiology

Camps-Font O, Sábado-Bundó H, Toledano-Serrabona J, Valmaseda-de-la-Rosa N, Figueiredo R, Valmaseda-Castellón E
Int J Oral Maxillofac Surg 2024 Jan;53(1):57-67. Epub 2023 Aug 21 doi: 10.1016/j.ijom.2023.08.001. PMID: 37612199
Hamel MS, Tuuli M
Obstet Gynecol Clin North Am 2023 Jun;50(2):327-338. Epub 2023 Apr 4 doi: 10.1016/j.ogc.2023.02.012. PMID: 37149313
Gaudias J
Orthop Traumatol Surg Res 2021 Feb;107(1S):102751. Epub 2020 Dec 11 doi: 10.1016/j.otsr.2020.102751. PMID: 33316449
Bashaw MA, Keister KJ
AORN J 2019 Jan;109(1):68-78. doi: 10.1002/aorn.12451. PMID: 30592511
Young PY, Khadaroo RG
Surg Clin North Am 2014 Dec;94(6):1245-64. Epub 2014 Oct 3 doi: 10.1016/j.suc.2014.08.008. PMID: 25440122

Diagnosis

Tuuli MG, Liu J, Tita ATN, Longo S, Trudell A, Carter EB, Shanks A, Woolfolk C, Caughey AB, Warren DK, Odibo AO, Colditz G, Macones GA, Harper L
JAMA 2020 Sep 22;324(12):1180-1189. doi: 10.1001/jama.2020.13361. PMID: 32960242Free PMC Article
Alkaaki A, Al-Radi OO, Khoja A, Alnawawi A, Alnawawi A, Maghrabi A, Altaf A, Aljiffry M
Can J Surg 2019 Apr 1;62(2):111-117. doi: 10.1503/cjs.004818. PMID: 30907567Free PMC Article
Ban KA, Minei JP, Laronga C, Harbrecht BG, Jensen EH, Fry DE, Itani KM, Dellinger EP, Ko CY, Duane TM
J Am Coll Surg 2017 Jan;224(1):59-74. Epub 2016 Nov 30 doi: 10.1016/j.jamcollsurg.2016.10.029. PMID: 27915053
Ding S, Lin F, Gillespie BM
J Wound Care 2016 May;25(5):232-40. doi: 10.12968/jowc.2016.25.5.232. PMID: 27169338
Tuuli MG, Liu J, Stout MJ, Martin S, Cahill AG, Odibo AO, Colditz GA, Macones GA
N Engl J Med 2016 Feb 18;374(7):647-55. Epub 2016 Feb 4 doi: 10.1056/NEJMoa1511048. PMID: 26844840Free PMC Article

Therapy

Major Extremity Trauma Research Consortium (METRC), O'Toole RV, Joshi M, Carlini AR, Murray CK, Allen LE, Huang Y, Scharfstein DO, O'Hara NN, Gary JL, Bosse MJ, Castillo RC, Bishop JA, Weaver MJ, Firoozabadi R, Hsu JR, Karunakar MA, Seymour RB, Sims SH, Churchill C, Brennan ML, Gonzales G, Reilly RM, Zura RD, Howes CR, Mir HR, Wagstrom EA, Westberg J, Gaski GE, Kempton LB, Natoli RM, Sorkin AT, Virkus WW, Hill LC, Hymes RA, Holzman M, Malekzadeh AS, Schulman JE, Ramsey L, Cuff JAN, Haaser S, Osgood GM, Shafiq B, Laljani V, Lee OC, Krause PC, Rowe CJ, Hilliard CL, Morandi MM, Mullins A, Achor TS, Choo AM, Munz JW, Boutte SJ, Vallier HA, Breslin MA, Frisch HM, Kaufman AM, Large TM, LeCroy CM, Riggsbee C, Smith CS, Crickard CV, Phieffer LS, Sheridan E, Jones CB, Sietsema DL, Reid JS, Ringenbach K, Hayda R, Evans AR, Crisco MJ, Rivera JC, Osborn PM, Kimmel J, Stawicki SP, Nwachuku CO, Wojda TR, Rehman S, Donnelly JM, Caroom C, Jenkins MD, Boulton CL, Costales TG, LeBrun CT, Manson TT, Mascarenhas DC, Nascone JW, Pollak AN, Sciadini MF, Slobogean GP, Berger PZ, Connelly DW, Degani Y, Howe AL, Marinos DP, Montalvo RN, Reahl GB, Schoonover CD, Schroder LK, Vang S, Bergin PF, Graves ML, Russell GV, Spitler CA, Hydrick JM, Teague D, Ertl W, Hickerson LE, Moloney GB, Weinlein JC, Zelle BA, Agarwal A, Karia RA, Sathy AK, Au B, Maroto M, Sanders D, Higgins TF, Haller JM, Rothberg DL, Weiss DB, Yarboro SR, McVey ED, Lester-Ballard V, Goodspeed D, Lang GJ, Whiting PS, Siy AB, Obremskey WT, Jahangir AA, Attum B, Burgos EJ, Molina CS, Rodriguez-Buitrago A, Gajari V, Trochez KM, Halvorson JJ, Miller AN, Goodman JB, Holden MB, McAndrew CM, Gardner MJ, Ricci WM, Spraggs-Hughes A, Collins SC, Taylor TJ, Zadnik M
JAMA Surg 2021 May 1;156(5):e207259. Epub 2021 May 12 doi: 10.1001/jamasurg.2020.7259. PMID: 33760010
Tuuli MG, Liu J, Tita ATN, Longo S, Trudell A, Carter EB, Shanks A, Woolfolk C, Caughey AB, Warren DK, Odibo AO, Colditz G, Macones GA, Harper L
JAMA 2020 Sep 22;324(12):1180-1189. doi: 10.1001/jama.2020.13361. PMID: 32960242Free PMC Article
Dumville JC, Gray TA, Walter CJ, Sharp CA, Page T, Macefield R, Blencowe N, Milne TK, Reeves BC, Blazeby J
Cochrane Database Syst Rev 2016 Dec 20;12(12):CD003091. doi: 10.1002/14651858.CD003091.pub4. PMID: 27996083Free PMC Article
Tanner J, Dumville JC, Norman G, Fortnam M
Cochrane Database Syst Rev 2016 Jan 22;2016(1):CD004288. doi: 10.1002/14651858.CD004288.pub3. PMID: 26799160Free PMC Article
Webster J, Osborne S
Cochrane Database Syst Rev 2015 Feb 20;2015(2):CD004985. doi: 10.1002/14651858.CD004985.pub5. PMID: 25927093Free PMC Article

Prognosis

Farid Mojtahedi M, Sepidarkish M, Almukhtar M, Eslami Y, Mohammadianamiri F, Behzad Moghadam K, Rouholamin S, Razavi M, Jafari Tadi M, Fazlollahpour-Naghibi A, Rostami Z, Rostami A, Rezaeinejad M
J Hosp Infect 2023 Sep;139:82-92. Epub 2023 Jun 10 doi: 10.1016/j.jhin.2023.05.019. PMID: 37308061
Mengistu DA, Alemu A, Abdukadir AA, Mohammed Husen A, Ahmed F, Mohammed B, Musa I
Inquiry 2023 Jan-Dec;60:469580231162549. doi: 10.1177/00469580231162549. PMID: 36964747Free PMC Article
Stryja J
Rozhl Chir 2021 Summer;100(7):313-324. doi: 10.33699/PIS.2021.100.7.313-324. PMID: 34465107
Alkaaki A, Al-Radi OO, Khoja A, Alnawawi A, Alnawawi A, Maghrabi A, Altaf A, Aljiffry M
Can J Surg 2019 Apr 1;62(2):111-117. doi: 10.1503/cjs.004818. PMID: 30907567Free PMC Article
Leaper D, Ousey K
Curr Opin Infect Dis 2015 Apr;28(2):158-63. doi: 10.1097/QCO.0000000000000144. PMID: 25692267

Clinical prediction guides

Chen M, Liang H, Chen M, Wang M, Lin L, Zhou C, Wei L
Int Wound J 2023 Nov;20(9):3884-3897. Epub 2023 Jun 20 doi: 10.1111/iwj.14264. PMID: 37337711Free PMC Article
Gwilym BL, Locker DT, Matthews EK, Mazumdar E, Adamson G, Wall ML, Bosanquet DC
Int Wound J 2023 Apr;20(4):1276-1291. Epub 2022 Oct 2 doi: 10.1111/iwj.13959. PMID: 36184849Free PMC Article
Hou Y, Hu Y, Song W, Zhang J, Luo Q, Zhou Q
Cancer Med 2022 Jun;11(11):2233-2243. Epub 2022 Feb 23 doi: 10.1002/cam4.4609. PMID: 35194968Free PMC Article
Prins JTH, Leasia K, Dull MB, Lawless RA, Platnick KB, Werner NL, Wijffels MME, Moore EE, Pieracci FM
Surg Infect (Larchmt) 2022 Feb;23(1):5-11. Epub 2021 Nov 11 doi: 10.1089/sur.2021.165. PMID: 34762547
Lober WB, Evans HL
Surg Infect (Larchmt) 2019 Oct;20(7):571-576. Epub 2019 Aug 9 doi: 10.1089/sur.2019.195. PMID: 31397635

Recent systematic reviews

Camps-Font O, Sábado-Bundó H, Toledano-Serrabona J, Valmaseda-de-la-Rosa N, Figueiredo R, Valmaseda-Castellón E
Int J Oral Maxillofac Surg 2024 Jan;53(1):57-67. Epub 2023 Aug 21 doi: 10.1016/j.ijom.2023.08.001. PMID: 37612199
Mengistu DA, Alemu A, Abdukadir AA, Mohammed Husen A, Ahmed F, Mohammed B, Musa I
Inquiry 2023 Jan-Dec;60:469580231162549. doi: 10.1177/00469580231162549. PMID: 36964747Free PMC Article
Badia JM, Casey AL, Petrosillo N, Hudson PM, Mitchell SA, Crosby C
J Hosp Infect 2017 May;96(1):1-15. Epub 2017 Mar 8 doi: 10.1016/j.jhin.2017.03.004. PMID: 28410761
Martin ET, Kaye KS, Knott C, Nguyen H, Santarossa M, Evans R, Bertran E, Jaber L
Infect Control Hosp Epidemiol 2016 Jan;37(1):88-99. Epub 2015 Oct 27 doi: 10.1017/ice.2015.249. PMID: 26503187Free PMC Article
Allegranzi B, Bagheri Nejad S, Combescure C, Graafmans W, Attar H, Donaldson L, Pittet D
Lancet 2011 Jan 15;377(9761):228-41. Epub 2010 Dec 9 doi: 10.1016/S0140-6736(10)61458-4. PMID: 21146207

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