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Unresponsive to Stimuli

MedGen UID:
208993
•Concept ID:
C0857494
•
Sign or Symptom
Synonym: Unresponsive to stimuli

Definition

An individual whose level of consciousness is such that he is not responsive to any stimulus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresponsive to Stimuli

Professional guidelines

PubMed

Anesthesia-induced loss of consciousness disrupts auditory responses beyond primary cortex.
Krom AJ, Marmelshtein A, Gelbard-Sagiv H, Tankus A, Hayat H, Hayat D, Matot I, Strauss I, Fahoum F, Soehle M, Boström J, Mormann F, Fried I, Nir Y
Proc Natl Acad Sci U S A 2020 May 26;117(21):11770-11780. Epub 2020 May 12 doi: 10.1073/pnas.1917251117. PMID: 32398367Free PMC Article
Pathogenesis and Management of Pruritus in PBC and PSC.
Kremer AE, Namer B, Bolier R, Fischer MJ, Oude Elferink RP, Beuers U
Dig Dis 2015;33 Suppl 2:164-75. Epub 2015 Dec 7 doi: 10.1159/000440829. PMID: 26641452
Heterogeneity in the pathology and treatment of asthma.
Peters SP
Am J Med 2003 Aug 18;115 Suppl 3A:49S-54S. doi: 10.1016/s0002-9343(03)00193-1. PMID: 12928075

Recent clinical studies

Etiology

Physical examination in functional unresponsiveness.
Bacchi S, Slee M
Pract Neurol 2023 Feb;23(1):54-56. Epub 2022 Sep 1 doi: 10.1136/pn-2022-003494. PMID: 36717206
Sputum from patients with primary ciliary dyskinesia contains high numbers of dysfunctional neutrophils and inhibits efferocytosis.
Blanter M, Cockx M, Wittebols L, Abouelasrar Salama S, De Bondt M, Berghmans N, Pörtner N, Vanbrabant L, Lorent N, Gouwy M, Boon M, Struyf S
Respir Res 2022 Dec 17;23(1):359. doi: 10.1186/s12931-022-02280-7. PMID: 36528664Free PMC Article
Responses to stimuli in the 'snoezelen' room in unresponsive wakefulness or in minimally responsive state.
Lehrer H, Dayan I, Elkayam K, Kfir A, Bierman U, Front L, Catz A, Aidinoff E
Brain Inj 2022 Jul 29;36(9):1167-1175. Epub 2022 Aug 17 doi: 10.1080/02699052.2022.2110286. PMID: 35978560
The Contribution of Gut Microbiota and Endothelial Dysfunction in the Development of Arterial Hypertension in Animal Models and in Humans.
Maiuolo J, Carresi C, Gliozzi M, Mollace R, Scarano F, Scicchitano M, Macrì R, Nucera S, Bosco F, Oppedisano F, Ruga S, Coppoletta AR, Guarnieri L, Cardamone A, Bava I, Musolino V, Paone S, Palma E, Mollace V
Int J Mol Sci 2022 Mar 28;23(7) doi: 10.3390/ijms23073698. PMID: 35409057Free PMC Article
Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury.
Claassen J, Doyle K, Matory A, Couch C, Burger KM, Velazquez A, Okonkwo JU, King JR, Park S, Agarwal S, Roh D, Megjhani M, Eliseyev A, Connolly ES, Rohaut B
N Engl J Med 2019 Jun 27;380(26):2497-2505. doi: 10.1056/NEJMoa1812757. PMID: 31242361

Diagnosis

Physical examination in functional unresponsiveness.
Bacchi S, Slee M
Pract Neurol 2023 Feb;23(1):54-56. Epub 2022 Sep 1 doi: 10.1136/pn-2022-003494. PMID: 36717206
Functional coma.
Ludwig L, McWhirter L, Williams S, Derry C, Stone J
Handb Clin Neurol 2016;139:313-327. doi: 10.1016/B978-0-12-801772-2.00028-X. PMID: 27719852
EEG and Coma.
Ardeshna NI
Neurodiagn J 2016 Mar;56(1):1-16. doi: 10.1080/21646821.2015.1114879. PMID: 27180503
Neurally mediated syncope.
Zaqqa M, Massumi A
Tex Heart Inst J 2000;27(3):268-72. PMID: 11093411Free PMC Article
Coma.
Liu GT
Neurosurg Clin N Am 1999 Oct;10(4):579-86, vii-viii. PMID: 10529971

Therapy

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.
Ng B, Dong J, D'Agostino G, Viswanathan S, Widjaja AA, Lim WW, Ko NSJ, Tan J, Chothani SP, Huang B, Xie C, Pua CJ, Chacko AM, Guimarães-Camboa N, Evans SM, Byrne AJ, Maher TM, Liang J, Jiang D, Noble PW, Schafer S, Cook SA
Sci Transl Med 2019 Sep 25;11(511) doi: 10.1126/scitranslmed.aaw1237. PMID: 31554736
Role of medicinal plants in HIV/AIDS therapy.
Laila U, Akram M, Shariati MA, Hashmi AM, Akhtar N, Tahir IM, Ghauri AO, Munir N, Riaz M, Akhter N, Shaheen G, Ullah Q, Zahid R, Ahmad S
Clin Exp Pharmacol Physiol 2019 Dec;46(12):1063-1073. Epub 2019 Aug 22 doi: 10.1111/1440-1681.13151. PMID: 31365763
Nicotinic agonists and psychosis.
Simosky JK, Stevens KE, Freedman R
Curr Drug Targets CNS Neurol Disord 2002 Apr;1(2):149-62. doi: 10.2174/1568007024606168. PMID: 12769624
Hypoparathyroidism.
Breslau NA, Pak CY
Metabolism 1979 Dec;28(12):1261-76. doi: 10.1016/0026-0495(79)90141-0. PMID: 390300
Prevention of prematurity.
Fuchs F
Am J Obstet Gynecol 1976 Dec 1;126(7):809-20. doi: 10.1016/0002-9378(76)90670-0. PMID: 11689

Prognosis

Covert Tracking to Visual Stimuli in Comatose Patients With Traumatic Brain Injury.
Alkhachroum A, Aklepi G, Sarafraz A, Robayo LE, Manolovitz BM, Blandino CF, Arwari B, Sobczak E, Bass DH, Ghamasaee P, Samano D, Massad N, Kottapally M, Merenda A, Dib S, Jagid JR, Dietrich WD, Rundek T, O'Phelan K, Claassen J, Walker MF
Neurology 2023 Sep 12;101(11):489-494. Epub 2023 Apr 19 doi: 10.1212/WNL.0000000000207302. PMID: 37076304Free PMC Article
Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery.
Pruvost-Robieux E, Marchi A, Martinelli I, Bouchereau E, Gavaret M
J Clin Neurophysiol 2022 Jan 1;39(1):22-31. doi: 10.1097/WNP.0000000000000762. PMID: 34474424Free PMC Article
Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury.
Claassen J, Doyle K, Matory A, Couch C, Burger KM, Velazquez A, Okonkwo JU, King JR, Park S, Agarwal S, Roh D, Megjhani M, Eliseyev A, Connolly ES, Rohaut B
N Engl J Med 2019 Jun 27;380(26):2497-2505. doi: 10.1056/NEJMoa1812757. PMID: 31242361
EEG and Coma.
Ardeshna NI
Neurodiagn J 2016 Mar;56(1):1-16. doi: 10.1080/21646821.2015.1114879. PMID: 27180503
Pathogenesis and Management of Pruritus in PBC and PSC.
Kremer AE, Namer B, Bolier R, Fischer MJ, Oude Elferink RP, Beuers U
Dig Dis 2015;33 Suppl 2:164-75. Epub 2015 Dec 7 doi: 10.1159/000440829. PMID: 26641452

Clinical prediction guides

Responses to stimuli in the 'snoezelen' room in unresponsive wakefulness or in minimally responsive state.
Lehrer H, Dayan I, Elkayam K, Kfir A, Bierman U, Front L, Catz A, Aidinoff E
Brain Inj 2022 Jul 29;36(9):1167-1175. Epub 2022 Aug 17 doi: 10.1080/02699052.2022.2110286. PMID: 35978560
Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery.
Pruvost-Robieux E, Marchi A, Martinelli I, Bouchereau E, Gavaret M
J Clin Neurophysiol 2022 Jan 1;39(1):22-31. doi: 10.1097/WNP.0000000000000762. PMID: 34474424Free PMC Article
Role of medicinal plants in HIV/AIDS therapy.
Laila U, Akram M, Shariati MA, Hashmi AM, Akhtar N, Tahir IM, Ghauri AO, Munir N, Riaz M, Akhter N, Shaheen G, Ullah Q, Zahid R, Ahmad S
Clin Exp Pharmacol Physiol 2019 Dec;46(12):1063-1073. Epub 2019 Aug 22 doi: 10.1111/1440-1681.13151. PMID: 31365763
Pathogenesis and Management of Pruritus in PBC and PSC.
Kremer AE, Namer B, Bolier R, Fischer MJ, Oude Elferink RP, Beuers U
Dig Dis 2015;33 Suppl 2:164-75. Epub 2015 Dec 7 doi: 10.1159/000440829. PMID: 26641452
Nicotinic agonists and psychosis.
Simosky JK, Stevens KE, Freedman R
Curr Drug Targets CNS Neurol Disord 2002 Apr;1(2):149-62. doi: 10.2174/1568007024606168. PMID: 12769624

Recent systematic reviews

Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review.
Aubinet C, Chatelle C, Gosseries O, Carrière M, Laureys S, Majerus S
Neurosci Biobehav Rev 2022 Jan;132:391-409. Epub 2021 Dec 2 doi: 10.1016/j.neubiorev.2021.12.001. PMID: 34864003
Can Salient Stimuli Enhance Responses in Disorders of Consciousness? A Systematic Review.
Magliacano A, De Bellis F, Galvao-Carmona A, Estraneo A, Trojano L
Curr Neurol Neurosci Rep 2019 Nov 26;19(12):98. doi: 10.1007/s11910-019-1018-8. PMID: 31773300
Comprehensive Systematic Review Update Summary: Disorders of Consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research.
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Arch Phys Med Rehabil 2018 Sep;99(9):1710-1719. Epub 2018 Aug 8 doi: 10.1016/j.apmr.2018.07.002. PMID: 30098792
Comprehensive systematic review update summary: Disorders of consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research.
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Neurology 2018 Sep 4;91(10):461-470. Epub 2018 Aug 8 doi: 10.1212/WNL.0000000000005928. PMID: 30089617Free PMC Article

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