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Brain hypoxia - ischemia

MedGen UID:
199862
Concept ID:
C0752308
Disease or Syndrome
Synonyms: Brain Hypoxia Ischemia; Brain Hypoxia-Ischemia; Brain Hypoxia-Ischemias; Brain Ischemia Hypoxia; Brain Ischemia-Hypoxia; Brain Ischemia-Hypoxias; Hypoxia Ischemia, Brain; Hypoxia-Ischemia, Brain; Hypoxia-Ischemias, Brain; Ischemia Hypoxia, Brain; Ischemia-Hypoxia, Brain; Ischemia-Hypoxias, Brain
 
Monarch Initiative: MONDO:0006685

Definition

A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ischemia) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrain hypoxia - ischemia

Professional guidelines

PubMed

Tejerina Álvarez EE, Lorente Balanza JÁ
Med Intensiva (Engl Ed) 2024 Jun;48(6):341-355. Epub 2024 Mar 15 doi: 10.1016/j.medine.2024.03.001. PMID: 38493062
Hirsch KG, Abella BS, Amorim E, Bader MK, Barletta JF, Berg K, Callaway CW, Friberg H, Gilmore EJ, Greer DM, Kern KB, Livesay S, May TL, Neumar RW, Nolan JP, Oddo M, Peberdy MA, Poloyac SM, Seder D, Taccone FS, Uzendu A, Walsh B, Zimmerman JL, Geocadin RG; American Heart Association, Neurocritical Care Society
Neurocrit Care 2024 Feb;40(1):1-37. Epub 2023 Dec 1 doi: 10.1007/s12028-023-01871-6. PMID: 38040992Free PMC Article
Hirsch KG, Abella BS, Amorim E, Bader MK, Barletta JF, Berg K, Callaway CW, Friberg H, Gilmore EJ, Greer DM, Kern KB, Livesay S, May TL, Neumar RW, Nolan JP, Oddo M, Peberdy MA, Poloyac SM, Seder D, Taccone FS, Uzendu A, Walsh B, Zimmerman JL, Geocadin RG; American Heart Association and Neurocritical Care Society
Circulation 2024 Jan 9;149(2):e168-e200. Epub 2023 Nov 28 doi: 10.1161/CIR.0000000000001163. PMID: 38014539Free PMC Article

Recent clinical studies

Etiology

Sokoloff M, Feldman KW, Levin AV, Rockter A, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Hymel KP; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2024 Mar;149:106606. Epub 2023 Dec 21 doi: 10.1016/j.chiabu.2023.106606. PMID: 38134727
Kiely DJ, Oppenheimer LW
Am J Obstet Gynecol MFM 2023 Aug;5(8):101021. Epub 2023 May 17 doi: 10.1016/j.ajogmf.2023.101021. PMID: 37201795
Netto CA, Sanches EF, Odorcyk F, Duran-Carabali LE, Sizonenko SV
Int J Dev Neurosci 2018 Nov;70:12-24. Epub 2018 Jun 18 doi: 10.1016/j.ijdevneu.2018.06.004. PMID: 29920306
Shao G, Wang Y, Guan S, Burlingame AL, Lu F, Knox R, Ferriero DM, Jiang X
Dev Neurosci 2017;39(1-4):66-81. Epub 2017 Mar 18 doi: 10.1159/000456030. PMID: 28315865Free PMC Article
Galvao TF, Silva MT, Marques MC, de Oliveira ND, Pereira MG
J Trop Pediatr 2013 Dec;59(6):453-9. Epub 2013 Jun 18 doi: 10.1093/tropej/fmt047. PMID: 23780995

Diagnosis

Sokoloff M, Feldman KW, Levin AV, Rockter A, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Hymel KP; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2024 Mar;149:106606. Epub 2023 Dec 21 doi: 10.1016/j.chiabu.2023.106606. PMID: 38134727
Hymel KP, Boos SC, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Even K, Wang M; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2022 Jul;129:105666. Epub 2022 May 11 doi: 10.1016/j.chiabu.2022.105666. PMID: 35567958Free PMC Article
Lakatos A, Kolossváry M, Szabó M, Jermendy Á, Barta H, Gyebnár G, Rudas G, Kozák LR
BMC Pediatr 2019 Nov 12;19(1):430. doi: 10.1186/s12887-019-1777-z. PMID: 31718607Free PMC Article
Hymel KP, Stoiko MA, Herman BE, Combs A, Harper NS, Lowen D, Deye KP, Homa K, Blackman JA
Pediatrics 2010 Apr;125(4):712-20. Epub 2010 Mar 29 doi: 10.1542/peds.2009-2133. PMID: 20351004
Roelants-Van Rijn AM, van der Grond J, de Vries LS, Groenendaal F
Pediatr Res 2001 Mar;49(3):356-62. doi: 10.1203/00006450-200103000-00009. PMID: 11228261

Therapy

Angelis D, Savani R, Chalak L
Pediatr Res 2021 Mar;89(4):746-752. Epub 2020 Jun 20 doi: 10.1038/s41390-020-1021-4. PMID: 32563184
Winerdal M, Urmaliya V, Winerdal ME, Fredholm BB, Winqvist O, Ådén U
PLoS One 2017;12(1):e0170545. Epub 2017 Jan 27 doi: 10.1371/journal.pone.0170545. PMID: 28129361Free PMC Article
Merelli A, Czornyj L, Lazarowski A
Int J Neurosci 2015;125(11):793-7. Epub 2015 Jan 9 doi: 10.3109/00207454.2014.989321. PMID: 25405533
Tocco NM, Hodge AE, Jones AA, Wispe JR, Valentine CJ
Nutr Clin Pract 2014 Apr;29(2):246-8. Epub 2014 Feb 18 doi: 10.1177/0884533614522835. PMID: 24549013
Galvao TF, Silva MT, Marques MC, de Oliveira ND, Pereira MG
J Trop Pediatr 2013 Dec;59(6):453-9. Epub 2013 Jun 18 doi: 10.1093/tropej/fmt047. PMID: 23780995

Prognosis

Koskensalo K, Virtanen S, Saunavaara J, Parkkola R, Laitio R, Arola O, Hynninen M, Silvasti P, Nukarinen E, Martola J, Silvennoinen HM, Tiainen M, Roine RO, Scheinin H, Saraste A, Maze M, Vahlberg T, Laitio TT; XeHYPOTHECA Research Group
Neuroradiology 2023 Feb;65(2):349-360. Epub 2022 Oct 17 doi: 10.1007/s00234-022-03063-z. PMID: 36251060Free PMC Article
Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E
Dev Neurosci 2022;44(4-5):277-294. Epub 2022 May 19 doi: 10.1159/000525150. PMID: 35588703Free PMC Article
Hymel KP, Boos SC, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Even K, Wang M; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2022 Jul;129:105666. Epub 2022 May 11 doi: 10.1016/j.chiabu.2022.105666. PMID: 35567958Free PMC Article
Lakatos A, Kolossváry M, Szabó M, Jermendy Á, Barta H, Gyebnár G, Rudas G, Kozák LR
BMC Pediatr 2019 Nov 12;19(1):430. doi: 10.1186/s12887-019-1777-z. PMID: 31718607Free PMC Article
Oehmichen M, Meissner C, von Wurmb-Schwark N, Schwark T
Leg Med (Tokyo) 2003 Dec;5(4):190-201. doi: 10.1016/s1344-6223(03)00077-4. PMID: 14602162

Clinical prediction guides

Yilmazer-Hanke D, Ouali Alami N, Fang L, Klotz S, Kovacs GG, Pankratz H, Weis J, Katona I, Scheuerle A, Streit WJ, Del Tredici K
Neuroscience 2022 Dec 1;506:91-113. Epub 2022 Nov 1 doi: 10.1016/j.neuroscience.2022.10.018. PMID: 36332693
Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E
Dev Neurosci 2022;44(4-5):277-294. Epub 2022 May 19 doi: 10.1159/000525150. PMID: 35588703Free PMC Article
Hymel KP, Boos SC, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Even K, Wang M; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2022 Jul;129:105666. Epub 2022 May 11 doi: 10.1016/j.chiabu.2022.105666. PMID: 35567958Free PMC Article
LaRocca TJ, Sosunov SA, Shakerley NL, Ten VS, Ratner AJ
J Biol Chem 2016 Jun 24;291(26):13753-61. Epub 2016 Apr 29 doi: 10.1074/jbc.M116.716027. PMID: 27129772Free PMC Article
Merelli A, Czornyj L, Lazarowski A
Int J Neurosci 2015;125(11):793-7. Epub 2015 Jan 9 doi: 10.3109/00207454.2014.989321. PMID: 25405533

Recent systematic reviews

Galvao TF, Silva MT, Marques MC, de Oliveira ND, Pereira MG
J Trop Pediatr 2013 Dec;59(6):453-9. Epub 2013 Jun 18 doi: 10.1093/tropej/fmt047. PMID: 23780995

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