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Central Nervous System Cavernous Hemangioma

MedGen UID:
199825
•Concept ID:
C0752160
•
Congenital Abnormality
Synonyms: Cavernous Hemangioma, Central Nervous System; Hemangioma, Cavernous, Central Nervous System

Definition

A cavernous hemangioma arising from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Cavernous Hemangioma

Professional guidelines

PubMed

In Reply to the Letter to the Editor Regarding "Propranolol Treatment of Cavernous Malformations with Symptomatic Hemorrhage".
Zabramski JM
World Neurosurg 2021 Jan;145:513. doi: 10.1016/j.wneu.2020.10.003. PMID: 33348494
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Current clinical management of brainstem cavernomas.
Bozinov O, Hatano T, Sarnthein J, Burkhardt JK, Bertalanffy H
Swiss Med Wkly 2010;140:w13120. Epub 2010 Nov 26 doi: 10.4414/smw.2010.13120. PMID: 21110237

Recent clinical studies

Etiology

Cavernous malformations.
Ganz JC
Prog Brain Res 2022;268(1):115-132. Epub 2022 Jan 6 doi: 10.1016/bs.pbr.2021.10.029. PMID: 35074077
CCM3 and cerebral cavernous malformation disease.
Wang K, Zhou HJ, Wang M
Stroke Vasc Neurol 2019 Jul;4(2):67-70. Epub 2019 Mar 2 doi: 10.1136/svn-2018-000195. PMID: 31338212Free PMC Article
Leksell Stereotactic Radiosurgery for Cavernous Malformations.
Lunsford LD, Niranjan A, Kano H, Monaco Iii EA, Flickinger JC
Prog Neurol Surg 2019;34:260-266. Epub 2019 May 16 doi: 10.1159/000493072. PMID: 31096254
Clinical Management of Cavernous Malformations.
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Pharmacotherapy for cavernous malformations.
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155

Diagnosis

Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations.
Ressler AK, Snellings DA, Girard R, Gallione CJ, Lightle R, Allen AS, Awad IA, Marchuk DA
Nat Commun 2023 Nov 2;14(1):7009. doi: 10.1038/s41467-023-42908-w. PMID: 37919320Free PMC Article
Cavernous Malformations: Updates in Surgical Management and Biology.
Dammann P, Santos AN, Wan XY, Zhu Y, Sure U
Neurosurg Clin N Am 2022 Oct;33(4):449-460. Epub 2022 Sep 11 doi: 10.1016/j.nec.2022.05.001. PMID: 36229132
Familial Cavernous Hemangioma.
Torres G, Kini AT, Al Othman B, Lee AG
J Neuroophthalmol 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269
Cerebral cavernous malformations and epilepsy.
Awad I, Jabbour P
Neurosurg Focus 2006 Jul 15;21(1):e7. doi: 10.3171/foc.2006.21.1.8. PMID: 16859260
Intracranial cavernous malformations.
Rivera PP, Willinsky RA, Porter PJ
Neuroimaging Clin N Am 2003 Feb;13(1):27-40. doi: 10.1016/s1052-5149(02)00060-6. PMID: 12802939

Therapy

Nontraumatic Pediatric Intracerebral Hemorrhage.
Boulouis G, Blauwblomme T, Hak JF, Benichi S, Kirton A, Meyer P, Chevignard M, Tournier-Lasserve E, Mackay MT, Chabrier S, Cordonnier C, Kossorotoff M, Naggara O
Stroke 2019 Dec;50(12):3654-3661. Epub 2019 Oct 22 doi: 10.1161/STROKEAHA.119.025783. PMID: 31637968
Familial Cerebral Cavernous Malformations.
Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L
Stroke 2019 May;50(5):1294-1301. doi: 10.1161/STROKEAHA.118.022314. PMID: 30909834Free PMC Article
Could propranolol be beneficial in adult cerebral cavernous malformations?
Apra C, Dumot C, Bourdillon P, Pelissou-Guyotat I
Neurosurg Rev 2019 Jun;42(2):403-408. Epub 2019 Jan 4 doi: 10.1007/s10143-018-01074-0. PMID: 30610500
Clinical Management of Cavernous Malformations.
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Pharmacotherapy for cavernous malformations.
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155

Prognosis

Cavernous Malformations: Updates in Surgical Management and Biology.
Dammann P, Santos AN, Wan XY, Zhu Y, Sure U
Neurosurg Clin N Am 2022 Oct;33(4):449-460. Epub 2022 Sep 11 doi: 10.1016/j.nec.2022.05.001. PMID: 36229132
Nontraumatic Pediatric Intracerebral Hemorrhage.
Boulouis G, Blauwblomme T, Hak JF, Benichi S, Kirton A, Meyer P, Chevignard M, Tournier-Lasserve E, Mackay MT, Chabrier S, Cordonnier C, Kossorotoff M, Naggara O
Stroke 2019 Dec;50(12):3654-3661. Epub 2019 Oct 22 doi: 10.1161/STROKEAHA.119.025783. PMID: 31637968
Epidemiology of cavernous malformations.
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML
Nature 2017 May 18;545(7654):305-310. Epub 2017 May 10 doi: 10.1038/nature22075. PMID: 28489816Free PMC Article
Cerebral cavernous malformations and epilepsy.
Awad I, Jabbour P
Neurosurg Focus 2006 Jul 15;21(1):e7. doi: 10.3171/foc.2006.21.1.8. PMID: 16859260

Clinical prediction guides

Seizure outcome in medically treated patients with adult-onset epilepsy and cerebral cavernous malformation.
Oh H, Im K, Yang HR, Kim HJ, Koo YS, Lee SA
Clin Neurol Neurosurg 2023 Oct;233:107951. Epub 2023 Aug 25 doi: 10.1016/j.clineuro.2023.107951. PMID: 37683297
Deciphering impact of single nucleotide polymorphisms on cotranscriptional modification in CCM gene mRNAs.
Scimone C, Donato L, Alibrandi S, Alafaci C, D'Ascola A, Vinci S, D'Angelo R, Sidoti A
Am J Physiol Cell Physiol 2022 Oct 1;323(4):C1274-C1284. Epub 2022 Sep 12 doi: 10.1152/ajpcell.00279.2022. PMID: 36094437
Editome landscape of CCM-derived endothelial cells.
Scimone C, Alibrandi S, Donato L, Alafaci C, Germanò A, Vinci SL, D'Angelo R, Sidoti A
RNA Biol 2022 Jan;19(1):852-865. doi: 10.1080/15476286.2022.2091306. PMID: 35771000Free PMC Article
Surgical treatment and long-term outcomes of thalamic cavernous malformations.
Li D, Zhang J, Hao S, Tang J, Xiao X, Wu Z, Zhang L
World Neurosurg 2013 May-Jun;79(5-6):704-13. Epub 2012 Jan 26 doi: 10.1016/j.wneu.2012.01.037. PMID: 22381871
Symptomatic brainstem cavernomas.
Hauck EF, Barnett SL, White JA, Samson D
Neurosurgery 2009 Jan;64(1):61-70; discussion 70-1. doi: 10.1227/01.NEU.0000335158.11692.53. PMID: 19050659

Recent systematic reviews

Early and long-term outcome of surgical versus conservative management for intracranial cerebral cavernous malformation: Meta-analysis of reconstructed time-to-event data.
da Fontoura Galvão G, Verly G, Valença P, Domingues FS, da Silva MR, Marcondes J
Clin Neurol Neurosurg 2024 Nov;246:108567. Epub 2024 Sep 21 doi: 10.1016/j.clineuro.2024.108567. PMID: 39332049
Radiation-induced cavernoma in pediatric CNS tumors: a systematic review and treatment paradigm.
Vacek A, Kaliaperumal C
Childs Nerv Syst 2024 Nov;40(11):3527-3536. Epub 2024 Jul 19 doi: 10.1007/s00381-024-06543-0. PMID: 39028348Free PMC Article
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Anterior visual pathway cavernous malformations.
Tan T, Tee JW, Trost N, McKelvie P, Wang YY
J Clin Neurosci 2015 Feb;22(2):258-67. Epub 2014 Nov 11 doi: 10.1016/j.jocn.2014.07.027. PMID: 25439746
Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review.
Campbell PG, Jabbour P, Yadla S, Awad IA
Neurosurg Focus 2010 Sep;29(3):E6. doi: 10.3171/2010.5.FOCUS10120. PMID: 20809764Free PMC Article

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