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Isolated optic neuritis without anti-MOG antibodies

MedGen UID:
1843279
•Concept ID:
C5680299
•
Disease or Syndrome
Synonyms: isolated optic neuritis without anti-MOG antibodies; Isolated optic neuritis without anti-myelin oligodendrocyte glycoprotein antibodies
 
Monarch Initiative: MONDO:0035667
Orphanet: ORPHA592885

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIsolated optic neuritis without anti-MOG antibodies

Professional guidelines

PubMed

Pathogenesis, Clinical Features, and Treatment of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Autoantibody-Associated Disorders Focusing on Optic Neuritis with Consideration of Autoantibody-Binding Sites: A Review.
Tanaka K, Kezuka T, Ishikawa H, Tanaka M, Sakimura K, Abe M, Kawamura M
Int J Mol Sci 2023 Aug 29;24(17) doi: 10.3390/ijms241713368. PMID: 37686172Free PMC Article

Recent clinical studies

Etiology

Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.
Nair A, Sankhyan N, Sukhija J, Saini AG, Vyas S, Suthar R, Sahu JK, Rawat A
Eur J Paediatr Neurol 2024 Mar;49:1-5. Epub 2024 Jan 17 doi: 10.1016/j.ejpn.2024.01.003. PMID: 38271780
Dual positivity for anti-MOG and oligoclonal bands: Unveiling unique clinical profiles and implications.
Ganelin-Cohen E, Shelly S, Schiller Y, Vaknin-Dembinsky A, Shachor M, Rechtman A, Osherov M, Duvdevan N, Rozenberg A
Mult Scler Relat Disord 2023 Nov;79:105034. Epub 2023 Oct 1 doi: 10.1016/j.msard.2023.105034. PMID: 37801958
Clinical and radiological profile of neuromyelitis optica spectrum disorders in a Pakistani cohort.
Rajput HM, Hassan M, Badshah M
Mult Scler Relat Disord 2023 Jun;74:104656. Epub 2023 Mar 24 doi: 10.1016/j.msard.2023.104656. PMID: 37068371
Myelin oligodendrocyte glycoprotein antibody-associated disease in children: Are there MRI predictors of relapse?
Singh S, Ness J, Marcus L
J Neuroradiol 2023 Jun;50(4):382-387. Epub 2023 Jan 4 doi: 10.1016/j.neurad.2022.11.003. PMID: 36609068
Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis.
Rostasy K, Mader S, Schanda K, Huppke P, Gärtner J, Kraus V, Karenfort M, Tibussek D, Blaschek A, Bajer-Kornek B, Leitz S, Schimmel M, Di Pauli F, Berger T, Reindl M
Arch Neurol 2012 Jun;69(6):752-6. doi: 10.1001/archneurol.2011.2956. PMID: 22371853

Diagnosis

Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.
Nair A, Sankhyan N, Sukhija J, Saini AG, Vyas S, Suthar R, Sahu JK, Rawat A
Eur J Paediatr Neurol 2024 Mar;49:1-5. Epub 2024 Jan 17 doi: 10.1016/j.ejpn.2024.01.003. PMID: 38271780
Pathogenesis, Clinical Features, and Treatment of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Autoantibody-Associated Disorders Focusing on Optic Neuritis with Consideration of Autoantibody-Binding Sites: A Review.
Tanaka K, Kezuka T, Ishikawa H, Tanaka M, Sakimura K, Abe M, Kawamura M
Int J Mol Sci 2023 Aug 29;24(17) doi: 10.3390/ijms241713368. PMID: 37686172Free PMC Article
Clinical and radiological profile of neuromyelitis optica spectrum disorders in a Pakistani cohort.
Rajput HM, Hassan M, Badshah M
Mult Scler Relat Disord 2023 Jun;74:104656. Epub 2023 Mar 24 doi: 10.1016/j.msard.2023.104656. PMID: 37068371
Acute Demyelinating Syndromes: A report of child neurology department of Sfax University Hospital.
Zouari Mallouli S, Ben Nsir S, Bouchaala W, Kamoun Feki F, Charfi Triki C
Mult Scler Relat Disord 2021 Nov;56:103291. Epub 2021 Sep 28 doi: 10.1016/j.msard.2021.103291. PMID: 34624647
Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis.
Lim ET, Berger T, Reindl M, Dalton CM, Fernando K, Keir G, Thompson EJ, Miller DH, Giovannoni G
Mult Scler 2005 Aug;11(4):492-4. doi: 10.1191/1352458505ms1187sr. PMID: 16042235

Therapy

Clinical spectrum, treatment and outcome of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease in children: a tertiary care experience.
Serin HM, Yilmaz S, Simsek E, Kanmaz S, Eraslan C, Aktan G, Tekgul H, Gokben S
Acta Neurol Belg 2021 Feb;121(1):231-239. Epub 2020 Nov 24 doi: 10.1007/s13760-020-01499-9. PMID: 33231843

Prognosis

Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.
Nair A, Sankhyan N, Sukhija J, Saini AG, Vyas S, Suthar R, Sahu JK, Rawat A
Eur J Paediatr Neurol 2024 Mar;49:1-5. Epub 2024 Jan 17 doi: 10.1016/j.ejpn.2024.01.003. PMID: 38271780
Clinical and radiological profile of neuromyelitis optica spectrum disorders in a Pakistani cohort.
Rajput HM, Hassan M, Badshah M
Mult Scler Relat Disord 2023 Jun;74:104656. Epub 2023 Mar 24 doi: 10.1016/j.msard.2023.104656. PMID: 37068371
Myelin oligodendrocyte glycoprotein antibody-associated disease in children: Are there MRI predictors of relapse?
Singh S, Ness J, Marcus L
J Neuroradiol 2023 Jun;50(4):382-387. Epub 2023 Jan 4 doi: 10.1016/j.neurad.2022.11.003. PMID: 36609068
Acute Demyelinating Syndromes: A report of child neurology department of Sfax University Hospital.
Zouari Mallouli S, Ben Nsir S, Bouchaala W, Kamoun Feki F, Charfi Triki C
Mult Scler Relat Disord 2021 Nov;56:103291. Epub 2021 Sep 28 doi: 10.1016/j.msard.2021.103291. PMID: 34624647
Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis.
Rostasy K, Mader S, Schanda K, Huppke P, Gärtner J, Kraus V, Karenfort M, Tibussek D, Blaschek A, Bajer-Kornek B, Leitz S, Schimmel M, Di Pauli F, Berger T, Reindl M
Arch Neurol 2012 Jun;69(6):752-6. doi: 10.1001/archneurol.2011.2956. PMID: 22371853

Clinical prediction guides

Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein.
Koç S, Şen S, Terzi Y, Kızılay F, Demir S, Bekar Aksoy D, Kurtuluş F, Bilge N, Idilman E, Uzunköprü C, Güngör S, Çilingir V, Ethemoğlu Ö, Boz C, Gümüş H, Kılıç AK, Kısabay A, Bir LS, Turan ÖF, Soysal A, Köseoğlu M, Tekgöl Uzuner G, Bayındır H, Canbaz Kabay S, Çam M, Yayla V, Tan H, Özcan A, Taşkapıoğlu Ö, Korkmaz M, Tamam Y, İnanç Y, Efendi H, Kotan D, Yetkin MF, Bilgiç AB, Saçmacı H, Demirci S, Çelik Y, Poyraz T, Terzi M
Balkan Med J 2024 Jul 5;41(4):272-279. Epub 2024 Jun 3 doi: 10.4274/balkanmedj.galenos.2024.2024-1-97. PMID: 38828767
Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.
Nair A, Sankhyan N, Sukhija J, Saini AG, Vyas S, Suthar R, Sahu JK, Rawat A
Eur J Paediatr Neurol 2024 Mar;49:1-5. Epub 2024 Jan 17 doi: 10.1016/j.ejpn.2024.01.003. PMID: 38271780
Clinical and radiological profile of neuromyelitis optica spectrum disorders in a Pakistani cohort.
Rajput HM, Hassan M, Badshah M
Mult Scler Relat Disord 2023 Jun;74:104656. Epub 2023 Mar 24 doi: 10.1016/j.msard.2023.104656. PMID: 37068371
Myelin oligodendrocyte glycoprotein antibody-associated disease in children: Are there MRI predictors of relapse?
Singh S, Ness J, Marcus L
J Neuroradiol 2023 Jun;50(4):382-387. Epub 2023 Jan 4 doi: 10.1016/j.neurad.2022.11.003. PMID: 36609068
Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis.
Rostasy K, Mader S, Schanda K, Huppke P, Gärtner J, Kraus V, Karenfort M, Tibussek D, Blaschek A, Bajer-Kornek B, Leitz S, Schimmel M, Di Pauli F, Berger T, Reindl M
Arch Neurol 2012 Jun;69(6):752-6. doi: 10.1001/archneurol.2011.2956. PMID: 22371853

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