Isolated optic neuritis with anti-MOG antibodies

MedGen UID:: 1842982
•Concept ID:: C5680300
•: Disease or Syndrome

Synonyms:	isolated optic neuritis with anti-MOG antibodies; Isolated optic neuritis with anti-myelin oligodendrocyte glycoprotein antibodies

Monarch Initiative:	MONDO:0035668
Orphanet:	ORPHA592888

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIsolated optic neuritis with anti-MOG antibodies

Autoimmune/inflammatory optic neuropathy
- Isolated optic neuritis
  - Isolated optic neuritis with anti-MOG antibodies

Professional guidelines

PubMed

Pathogenesis, Clinical Features, and Treatment of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Autoantibody-Associated Disorders Focusing on Optic Neuritis with Consideration of Autoantibody-Binding Sites: A Review.

Tanaka K, Kezuka T, Ishikawa H, Tanaka M, Sakimura K, Abe M, Kawamura M
Int J Mol Sci 2023 Aug 29;24(17) doi: 10.3390/ijms241713368. PMID: 37686172 Free PMC Article

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Recent clinical studies

Therapy

Clinical spectrum, treatment and outcome of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease in children: a tertiary care experience.

Serin HM, Yilmaz S, Simsek E, Kanmaz S, Eraslan C, Aktan G, Tekgul H, Gokben S
Acta Neurol Belg 2021 Feb;121(1):231-239. Epub 2020 Nov 24 doi: 10.1007/s13760-020-01499-9. PMID: 33231843

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Prognosis

Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.

Nair A, Sankhyan N, Sukhija J, Saini AG, Vyas S, Suthar R, Sahu JK, Rawat A
Eur J Paediatr Neurol 2024 Mar;49:1-5. Epub 2024 Jan 17 doi: 10.1016/j.ejpn.2024.01.003. PMID: 38271780

Clinical and radiological profile of neuromyelitis optica spectrum disorders in a Pakistani cohort.

Rajput HM, Hassan M, Badshah M
Mult Scler Relat Disord 2023 Jun;74:104656. Epub 2023 Mar 24 doi: 10.1016/j.msard.2023.104656. PMID: 37068371

Myelin oligodendrocyte glycoprotein antibody-associated disease in children: Are there MRI predictors of relapse?

Singh S, Ness J, Marcus L
J Neuroradiol 2023 Jun;50(4):382-387. Epub 2023 Jan 4 doi: 10.1016/j.neurad.2022.11.003. PMID: 36609068

Acute Demyelinating Syndromes: A report of child neurology department of Sfax University Hospital.

Zouari Mallouli S, Ben Nsir S, Bouchaala W, Kamoun Feki F, Charfi Triki C
Mult Scler Relat Disord 2021 Nov;56:103291. Epub 2021 Sep 28 doi: 10.1016/j.msard.2021.103291. PMID: 34624647

Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis.

Rostasy K, Mader S, Schanda K, Huppke P, Gärtner J, Kraus V, Karenfort M, Tibussek D, Blaschek A, Bajer-Kornek B, Leitz S, Schimmel M, Di Pauli F, Berger T, Reindl M
Arch Neurol 2012 Jun;69(6):752-6. doi: 10.1001/archneurol.2011.2956. PMID: 22371853

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Clinical prediction guides

Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein.

Koç S, Şen S, Terzi Y, Kızılay F, Demir S, Bekar Aksoy D, Kurtuluş F, Bilge N, Idilman E, Uzunköprü C, Güngör S, Çilingir V, Ethemoğlu Ö, Boz C, Gümüş H, Kılıç AK, Kısabay A, Bir LS, Turan ÖF, Soysal A, Köseoğlu M, Tekgöl Uzuner G, Bayındır H, Canbaz Kabay S, Çam M, Yayla V, Tan H, Özcan A, Taşkapıoğlu Ö, Korkmaz M, Tamam Y, İnanç Y, Efendi H, Kotan D, Yetkin MF, Bilgiç AB, Saçmacı H, Demirci S, Çelik Y, Poyraz T, Terzi M
Balkan Med J 2024 Jul 5;41(4):272-279. Epub 2024 Jun 3 doi: 10.4274/balkanmedj.galenos.2024.2024-1-97. PMID: 38828767