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Acquired neuromuscular junction disease

MedGen UID:
1842295
•Concept ID:
C5681732
•
Disease or Syndrome
Orphanet: ORPHA98494

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcquired neuromuscular junction disease

Professional guidelines

PubMed

Clinical and imaging clues to the diagnosis and follow-up of ptosis and ophthalmoparesis.
Keene KR, Kan HE, van der Meeren S, Verbist BM, Tannemaat MR, Beenakker JM, Verschuuren JJGM
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2820-2834. Epub 2022 Sep 29 doi: 10.1002/jcsm.13089. PMID: 36172973Free PMC Article
Guidelines for genetic testing of muscle and neuromuscular junction disorders.
Nicolau S, Milone M, Liewluck T
Muscle Nerve 2021 Sep;64(3):255-269. Epub 2021 Jun 16 doi: 10.1002/mus.27337. PMID: 34133031
Treatment of myasthenia gravis: focus on pyridostigmine.
Maggi L, Mantegazza R
Clin Drug Investig 2011 Oct 1;31(10):691-701. doi: 10.2165/11593300-000000000-00000. PMID: 21815707

Recent clinical studies

Etiology

Disease-Based Prognostication: Myasthenia Gravis.
Almodovar JL, Mehrabyan A
Semin Neurol 2023 Oct;43(5):799-806. Epub 2023 Sep 26 doi: 10.1055/s-0043-1775791. PMID: 37751854
Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs.
Guzman KMH, Harkin K
J Am Anim Hosp Assoc 2023 Sep 1;59(5):249-254. doi: 10.5326/JAAHA-MS-7353. PMID: 37708471
Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity.
Meriggioli MN, Sanders DB
Lancet Neurol 2009 May;8(5):475-90. doi: 10.1016/S1474-4422(09)70063-8. PMID: 19375665Free PMC Article
Travel medicine interventions and neurological disease.
Giovanetti F
Travel Med Infect Dis 2007 Jan;5(1):7-17. Epub 2006 May 18 doi: 10.1016/j.tmaid.2006.03.002. PMID: 17161313
Eye movement disorders.
Liu GT, Volpe NJ, Galetta SL
Curr Opin Ophthalmol 1995 Dec;6(6):27-33. doi: 10.1097/00055735-199512000-00005. PMID: 10160415

Diagnosis

Disease-Based Prognostication: Myasthenia Gravis.
Almodovar JL, Mehrabyan A
Semin Neurol 2023 Oct;43(5):799-806. Epub 2023 Sep 26 doi: 10.1055/s-0043-1775791. PMID: 37751854
Suspected Fluoroquinolone-Induced Exacerbation of Myasthenia Gravis in Dogs.
Guzman KMH, Harkin K
J Am Anim Hosp Assoc 2023 Sep 1;59(5):249-254. doi: 10.5326/JAAHA-MS-7353. PMID: 37708471
Infantile and Early Acquired Ophthalmoplegic Syndromes.
Hunter DG
J Binocul Vis Ocul Motil 2018 Jan-Mar;68(1):7-9. Epub 2018 Jan 17 doi: 10.1080/2576117X.2017.1416039. PMID: 30196778
Acquired blepharoptosis.
Oosterhuis HJ
Clin Neurol Neurosurg 1996 Feb;98(1):1-7. doi: 10.1016/0303-8467(95)00087-9. PMID: 8681470
Eye movement disorders.
Liu GT, Volpe NJ, Galetta SL
Curr Opin Ophthalmol 1995 Dec;6(6):27-33. doi: 10.1097/00055735-199512000-00005. PMID: 10160415

Therapy

Immunoadsorption in patients with autoimmune ion channel disorders of the peripheral nervous system.
Antozzi C
Atheroscler Suppl 2013 Jan;14(1):219-22. doi: 10.1016/j.atherosclerosissup.2012.10.027. PMID: 23357168
Treatment of myasthenia gravis: focus on pyridostigmine.
Maggi L, Mantegazza R
Clin Drug Investig 2011 Oct 1;31(10):691-701. doi: 10.2165/11593300-000000000-00000. PMID: 21815707
Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity.
Meriggioli MN, Sanders DB
Lancet Neurol 2009 May;8(5):475-90. doi: 10.1016/S1474-4422(09)70063-8. PMID: 19375665Free PMC Article
Advances in myasthenia gravis.
Ciafaloni E, Sanders DB
Curr Neurol Neurosci Rep 2002 Jan;2(1):89-95. doi: 10.1007/s11910-002-0058-6. PMID: 11898588
Myasthenia gravis--current concepts.
Herrmann C Jr, Lindstrom JM, Keesey JC, Mulder DG
West J Med 1985 Jun;142(6):797-809. PMID: 3895751Free PMC Article

Prognosis

Disease-Based Prognostication: Myasthenia Gravis.
Almodovar JL, Mehrabyan A
Semin Neurol 2023 Oct;43(5):799-806. Epub 2023 Sep 26 doi: 10.1055/s-0043-1775791. PMID: 37751854
The expectant management of a rare neonatal disease: transient neonatal myasthenia gravis.
Masra F, Ishak S, Cheah FC
Turk J Pediatr 2023;65(2):321-325. doi: 10.24953/turkjped.2022.717. PMID: 37114697
Clinical outcome of generalized myasthenia gravis in Hong Kong Chinese.
Lee CY, Lam CL, Pang SY, Lau KK, Teo KC, Chang RS, Chan KH
J Neuroimmunol 2015 Dec 15;289:177-81. Epub 2015 Oct 30 doi: 10.1016/j.jneuroim.2015.10.018. PMID: 26616888
Predictable recovery from myasthenia gravis crisis with plasma exchange: thirty-six cases and review of current management.
Mahalati K, Dawson RB, Collins JO, Mayer RF
J Clin Apher 1999;14(1):1-8. doi: 10.1002/(sici)1098-1101(1999)14:1<1::aid-jca1>3.0.co;2-u. PMID: 10355656
Remission of myasthenia gravis following plasma-exchange.
Pinching AJ, Peters DK
Lancet 1976 Dec 25;2(8000):1373-6. doi: 10.1016/s0140-6736(76)91917-6. PMID: 63848

Clinical prediction guides

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis.
Vergoossen DLE, Plomp JJ, Gstöttner C, Fillié-Grijpma YE, Augustinus R, Verpalen R, Wuhrer M, Parren PWHI, Dominguez-Vega E, van der Maarel SM, Verschuuren JJ, Huijbers MG
Proc Natl Acad Sci U S A 2021 Mar 30;118(13) doi: 10.1073/pnas.2020635118. PMID: 33753489Free PMC Article
Review on Toll-Like Receptor Activation in Myasthenia Gravis: Application to the Development of New Experimental Models.
Robinet M, Maillard S, Cron MA, Berrih-Aknin S, Le Panse R
Clin Rev Allergy Immunol 2017 Feb;52(1):133-147. doi: 10.1007/s12016-016-8549-4. PMID: 27207173
Neuromuscular junction disorders.
Verschuuren J, Strijbos E, Vincent A
Handb Clin Neurol 2016;133:447-66. doi: 10.1016/B978-0-444-63432-0.00024-4. PMID: 27112691
Neonatal Outcome in Pregnancies with Autoimmune Myasthenia Gravis.
Jovandaric MZ, Despotovic DJ, Jesic MM, Jesic MD
Fetal Pediatr Pathol 2016;35(3):167-72. Epub 2016 Apr 21 doi: 10.3109/15513815.2016.1164773. PMID: 27100475
Pharmacologic treatment of downstream of tyrosine kinase 7 congenital myasthenic syndrome.
Witting N, Vissing J
JAMA Neurol 2014 Mar;71(3):350-4. doi: 10.1001/jamaneurol.2013.5590. PMID: 24425145

Recent systematic reviews

Effectiveness and safety of tacrolimus therapy for myasthenia gravis: A single arm meta-analysis.
Wang L, Xi J, Zhang S, Wu H, Zhou L, Lu J, Zhang T, Zhao C
J Clin Neurosci 2019 May;63:160-167. Epub 2019 Mar 1 doi: 10.1016/j.jocn.2019.02.004. PMID: 30827886
Advances in myasthenia gravis.
Ciafaloni E, Sanders DB
Curr Neurol Neurosci Rep 2002 Jan;2(1):89-95. doi: 10.1007/s11910-002-0058-6. PMID: 11898588

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