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Decreased circulating norepinephrine concentration

MedGen UID:
1842065
•Concept ID:
C5826728
•
Finding
HPO: HP:0034874

Definition

Concentration of norepinephrin in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating norepinephrine concentration

Professional guidelines

PubMed

Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence.
McCulloch L, Allan SM, Emsley HC, Smith CJ, McColl BW
F1000Res 2019;8:1039. Epub 2019 Jul 10 doi: 10.12688/f1000research.19308.2. PMID: 31700615Free PMC Article
Blood pressure and neurohormonal responses to renal nerve ablation in treatment-resistant hypertension.
Ezzahti M, Moelker A, Friesema EC, van der Linde NA, Krestin GP, van den Meiracker AH
J Hypertens 2014 Jan;32(1):135-41. doi: 10.1097/HJH.0b013e3283658ef7. PMID: 24131897
Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression.
Fleishaker JC
Clin Pharmacokinet 2000 Dec;39(6):413-27. doi: 10.2165/00003088-200039060-00003. PMID: 11192474

Recent clinical studies

Etiology

Exercise-induced changes on exerkines that might influence brown adipose tissue metabolism in young sedentary adults.
Mendez-Gutierrez A, Aguilera CM, Osuna-Prieto FJ, Martinez-Tellez B, Rico Prados MC, Acosta FM, Llamas-Elvira JM, Ruiz JR, Sanchez-Delgado G
Eur J Sport Sci 2023 Apr;23(4):625-636. Epub 2022 Apr 25 doi: 10.1080/17461391.2022.2040597. PMID: 35152857
Perioperative metabolic changes in patients undergoing cardiac surgery.
Jakob SM, Stanga Z
Nutrition 2010 Apr;26(4):349-53. Epub 2010 Jan 6 doi: 10.1016/j.nut.2009.07.014. PMID: 20053534
Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances.
Ortega E, García JJ, Bote ME, Martín-Cordero L, Escalante Y, Saavedra JM, Northoff H, Giraldo E
Exerc Immunol Rev 2009;15:42-65. PMID: 19957871
Arginine vasopressin in 316 patients with advanced vasodilatory shock.
Luckner G, Dünser MW, Jochberger S, Mayr VD, Wenzel V, Ulmer H, Schmid S, Knotzer H, Pajk W, Hasibeder W, Mayr AJ, Friesenecker B
Crit Care Med 2005 Nov;33(11):2659-66. doi: 10.1097/01.ccm.0000186749.34028.40. PMID: 16276194
Pathophysiologic role of the renin-angiotensin-aldosterone and sympathetic nervous systems in heart failure.
Adams KF Jr
Am J Health Syst Pharm 2004 May 1;61 Suppl 2:S4-13. doi: 10.1093/ajhp/61.suppl_2.S4. PMID: 15160833

Diagnosis

Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chances.
Ortega E, García JJ, Bote ME, Martín-Cordero L, Escalante Y, Saavedra JM, Northoff H, Giraldo E
Exerc Immunol Rev 2009;15:42-65. PMID: 19957871
Arginine vasopressin in 316 patients with advanced vasodilatory shock.
Luckner G, Dünser MW, Jochberger S, Mayr VD, Wenzel V, Ulmer H, Schmid S, Knotzer H, Pajk W, Hasibeder W, Mayr AJ, Friesenecker B
Crit Care Med 2005 Nov;33(11):2659-66. doi: 10.1097/01.ccm.0000186749.34028.40. PMID: 16276194
The broader view: catecholamine abnormalities.
Vincent S, Robertson D
Clin Auton Res 2002 May;12 Suppl 1:I44-9. doi: 10.1007/s102860200018. PMID: 12102462
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
Nehlig A, Daval JL, Debry G
Brain Res Brain Res Rev 1992 May-Aug;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b. PMID: 1356551
Haemodynamic monitoring. Problems, pitfalls and practical solutions.
Bossaert LL, Demey HE, De Jongh R, Heytens L
Drugs 1991 Jun;41(6):857-74. doi: 10.2165/00003495-199141060-00004. PMID: 1715263

Therapy

The Safety and Efficacy of Peripherally Administered Norepinephrine during the Perioperative Period.
Simons C
AANA J 2022 Oct;90(5):387-395. PMID: 36173798
Metabolic changes after cardiac surgery.
Jakob SM, Ensinger H, Takala J
Curr Opin Clin Nutr Metab Care 2001 Mar;4(2):149-55. doi: 10.1097/00075197-200103000-00012. PMID: 11224661
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
Nehlig A, Daval JL, Debry G
Brain Res Brain Res Rev 1992 May-Aug;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b. PMID: 1356551
Plasma dopamine: regulation and significance.
Van Loon GR
Fed Proc 1983 Oct;42(13):3012-8. PMID: 6413258
Carbohydrate metabolism in cardiovascular disease.
Opie LH, Stubbs WA
Clin Endocrinol Metab 1976 Nov;5(3):703-29. doi: 10.1016/s0300-595x(76)80047-3. PMID: 797485

Prognosis

Circulating renalase, catecholamines, and vascular adhesion protein 1 in hypertensive patients.
Maciorkowska D, Zbroch E, Malyszko J
J Am Soc Hypertens 2015 Nov;9(11):855-64. Epub 2015 Aug 12 doi: 10.1016/j.jash.2015.08.002. PMID: 26403854
Short-term responses of the kidney to high altitude in mountain climbers.
Goldfarb-Rumyantzev AS, Alper SL
Nephrol Dial Transplant 2014 Mar;29(3):497-506. Epub 2013 Mar 22 doi: 10.1093/ndt/gft051. PMID: 23525530Free PMC Article
Arginine vasopressin in 316 patients with advanced vasodilatory shock.
Luckner G, Dünser MW, Jochberger S, Mayr VD, Wenzel V, Ulmer H, Schmid S, Knotzer H, Pajk W, Hasibeder W, Mayr AJ, Friesenecker B
Crit Care Med 2005 Nov;33(11):2659-66. doi: 10.1097/01.ccm.0000186749.34028.40. PMID: 16276194
Plasma dopamine: regulation and significance.
Van Loon GR
Fed Proc 1983 Oct;42(13):3012-8. PMID: 6413258
Labile (borderline) hypertension--new aspects of a common disorder.
Kuchel O, Cuche JL, Hamet P, Tolis G, Messerli FH, Barbeau A, Boucher R, Genest J
Angiology 1975 Sep;26(8):619-31. doi: 10.1177/000331977502600805. PMID: 233754

Clinical prediction guides

Short-term responses of the kidney to high altitude in mountain climbers.
Goldfarb-Rumyantzev AS, Alper SL
Nephrol Dial Transplant 2014 Mar;29(3):497-506. Epub 2013 Mar 22 doi: 10.1093/ndt/gft051. PMID: 23525530Free PMC Article
Pathophysiologic role of the renin-angiotensin-aldosterone and sympathetic nervous systems in heart failure.
Adams KF Jr
Am J Health Syst Pharm 2004 May 1;61 Suppl 2:S4-13. doi: 10.1093/ajhp/61.suppl_2.S4. PMID: 15160833
Pharmacokinetics of cardiovascular drugs in children. Inotropes and vasopressors.
Steinberg C, Notterman DA
Clin Pharmacokinet 1994 Nov;27(5):345-67. doi: 10.2165/00003088-199427050-00003. PMID: 7851053
Renal perfusion and metabolism in experimental endotoxin shock.
Gullichsen E
Acta Chir Scand Suppl 1991;560:7-31. PMID: 1828126
The impact of aging on adrenergic receptor function: clinical and biochemical aspects.
Heinsimer JA, Lefkowitz RJ
J Am Geriatr Soc 1985 Mar;33(3):184-8. doi: 10.1111/j.1532-5415.1985.tb04890.x. PMID: 2857740

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