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Elevated circulating growth hormone-releasing hormone concentration

MedGen UID:
1842063
•Concept ID:
C5826748
•
Finding
HPO: HP:0034898

Definition

Concentration of growth hormone-releasing hormone above the upper limit of normal in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating growth hormone-releasing hormone concentration

Recent clinical studies

Etiology

Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.
Nasioudis D, Minis E, Irani M, Kreines F, Witkin SS, Spandorfer SD
J Assist Reprod Genet 2019 Dec;36(12):2485-2491. Epub 2019 Nov 21 doi: 10.1007/s10815-019-01618-3. PMID: 31755001Free PMC Article
Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.
Dauber A, Muñoz-Calvo MT, Barrios V, Domené HM, Kloverpris S, Serra-Juhé C, Desikan V, Pozo J, Muzumdar R, Martos-Moreno GÁ, Hawkins F, Jasper HG, Conover CA, Frystyk J, Yakar S, Hwa V, Chowen JA, Oxvig C, Rosenfeld RG, Pérez-Jurado LA, Argente J
EMBO Mol Med 2016 Apr 1;8(4):363-74. doi: 10.15252/emmm.201506106. PMID: 26902202Free PMC Article
The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants.
Korbonits M, Little JA, Forsling ML, Tringali G, Costa A, Navarra P, Trainer PJ, Grossman AB
J Neuroendocrinol 1999 Jul;11(7):521-8. doi: 10.1046/j.1365-2826.1999.00353.x. PMID: 10444309
Pituitary dysfunction in recently post-menopausal women. Nottingham EPIC Study Group.
Lyons A, Ng C, Fielding K, Hosking D, Selby C, Lawson N
Clin Endocrinol (Oxf) 1997 Oct;47(4):431-8. doi: 10.1046/j.1365-2265.1997.2761083.x. PMID: 9404441
Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses.
Goland RS, Jozak S, Warren WB, Conwell IM, Stark RI, Tropper PJ
J Clin Endocrinol Metab 1993 Nov;77(5):1174-9. doi: 10.1210/jcem.77.5.8077309. PMID: 8077309

Diagnosis

Growth Hormone Response to Oral Glucose Load: From Normal to Pathological Conditions.
Hage M, Kamenický P, Chanson P
Neuroendocrinology 2019;108(3):244-255. Epub 2019 Jan 25 doi: 10.1159/000497214. PMID: 30685760
Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly.
Kovacs M, Kineman RD, Schally AV, Zarandi M, Groot K, Frohman LA
Endocrinology 1997 Nov;138(11):4536-42. doi: 10.1210/endo.138.11.5498. PMID: 9348175
Immunoreactive growth hormone-releasing hormone (IR-GHRH) in the feto-placental circulation and differential effects of L-dopa, L-arginine and somatostatin-14 on the plasma levels of IR-GHRH in normal adults.
Saito H, Hosoi E, Yamasaki R, Kameyama K, Irahara M, Ohno Y, Saito S
Horm Metab Res 1997 Apr;29(4):184-9. doi: 10.1055/s-2007-979018. PMID: 9178029
The measurement of insulin-like growth factor I: clinical applications and significance.
Teale JD, Marks V
Ann Clin Biochem 1986 Jul;23 ( Pt 4):413-24. doi: 10.1177/000456328602300406. PMID: 3094423
Disorders of prolactin and growth hormone secretion.
Ho KY, Evans WS, Thorner MO
Clin Endocrinol Metab 1985 Feb;14(1):1-32. doi: 10.1016/s0300-595x(85)80063-3. PMID: 3926353

Therapy

Growth hormone secretagogues in critical illness.
Van den Berghe G
Horm Res 1999;51 Suppl 3:21-8. doi: 10.1159/000053158. PMID: 10592440
Leptin levels in protracted critical illness: effects of growth hormone-secretagogues and thyrotropin-releasing hormone.
Van den Berghe G, Wouters P, Carlsson L, Baxter RC, Bouillon R, Bowers CY
J Clin Endocrinol Metab 1998 Sep;83(9):3062-70. doi: 10.1210/jcem.83.9.5120. PMID: 9745404
Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly.
Kovacs M, Kineman RD, Schally AV, Zarandi M, Groot K, Frohman LA
Endocrinology 1997 Nov;138(11):4536-42. doi: 10.1210/endo.138.11.5498. PMID: 9348175
The measurement of insulin-like growth factor I: clinical applications and significance.
Teale JD, Marks V
Ann Clin Biochem 1986 Jul;23 ( Pt 4):413-24. doi: 10.1177/000456328602300406. PMID: 3094423
Disorders of prolactin and growth hormone secretion.
Ho KY, Evans WS, Thorner MO
Clin Endocrinol Metab 1985 Feb;14(1):1-32. doi: 10.1016/s0300-595x(85)80063-3. PMID: 3926353

Prognosis

Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.
Nasioudis D, Minis E, Irani M, Kreines F, Witkin SS, Spandorfer SD
J Assist Reprod Genet 2019 Dec;36(12):2485-2491. Epub 2019 Nov 21 doi: 10.1007/s10815-019-01618-3. PMID: 31755001Free PMC Article
Growth hormone secretagogues in critical illness.
Van den Berghe G
Horm Res 1999;51 Suppl 3:21-8. doi: 10.1159/000053158. PMID: 10592440
Leukemia inhibitory factor (LIF) modulates pro-opiomelanocortin (POMC) gene regulation in stably transfected AtT-20 cells overexpressing LIF.
Li QL, Yano H, Ren SG, Li X, Friedman TC, Melmed S
Endocrine 1997 Dec;7(3):325-30. doi: 10.1007/BF02801326. PMID: 9657069
Ovarian sensitivity to gonadotrophins in patients with PCO is unaffected by suppression of LH.
Fleming R, Hamilton MP, Conaghan C, Black WP, Coutts JR
Clin Endocrinol (Oxf) 1990 Jan;32(1):33-8. doi: 10.1111/j.1365-2265.1990.tb03747.x. PMID: 2110046
The measurement of insulin-like growth factor I: clinical applications and significance.
Teale JD, Marks V
Ann Clin Biochem 1986 Jul;23 ( Pt 4):413-24. doi: 10.1177/000456328602300406. PMID: 3094423

Clinical prediction guides

Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.
Nasioudis D, Minis E, Irani M, Kreines F, Witkin SS, Spandorfer SD
J Assist Reprod Genet 2019 Dec;36(12):2485-2491. Epub 2019 Nov 21 doi: 10.1007/s10815-019-01618-3. PMID: 31755001Free PMC Article
Growth Hormone Response to Oral Glucose Load: From Normal to Pathological Conditions.
Hage M, Kamenický P, Chanson P
Neuroendocrinology 2019;108(3):244-255. Epub 2019 Jan 25 doi: 10.1159/000497214. PMID: 30685760
The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants.
Korbonits M, Little JA, Forsling ML, Tringali G, Costa A, Navarra P, Trainer PJ, Grossman AB
J Neuroendocrinol 1999 Jul;11(7):521-8. doi: 10.1046/j.1365-2826.1999.00353.x. PMID: 10444309
Immunoreactive growth hormone-releasing hormone (IR-GHRH) in the feto-placental circulation and differential effects of L-dopa, L-arginine and somatostatin-14 on the plasma levels of IR-GHRH in normal adults.
Saito H, Hosoi E, Yamasaki R, Kameyama K, Irahara M, Ohno Y, Saito S
Horm Metab Res 1997 Apr;29(4):184-9. doi: 10.1055/s-2007-979018. PMID: 9178029
The measurement of insulin-like growth factor I: clinical applications and significance.
Teale JD, Marks V
Ann Clin Biochem 1986 Jul;23 ( Pt 4):413-24. doi: 10.1177/000456328602300406. PMID: 3094423

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