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Increased CSF uracil concentration

MedGen UID:
1841961
•Concept ID:
C5826409
•
Finding
HPO: HP:0034460

Definition

An increased level of uracil in the cerebrospinal fluid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased CSF uracil concentration

Professional guidelines

PubMed

Cytokine changes in response to radio-/chemotherapeutic treatment in head and neck cancer.
Reers S, Pfannerstill AC, Rades D, Maushagen R, Andratschke M, Pries R, Wollenberg B
Anticancer Res 2013 Jun;33(6):2481-9. PMID: 23749899

Recent clinical studies

Etiology

Characterization of endogenous G-CSF and the inverse correlation to chemotherapy-induced neutropenia in patients with breast cancer using population modeling.
Quartino AL, Karlsson MO, Lindman H, Friberg LE
Pharm Res 2014 Dec;31(12):3390-403. Epub 2014 Jun 12 doi: 10.1007/s11095-014-1429-9. PMID: 24919931
Influence of varying doses of granulocyte-macrophage colony-stimulating factor on pharmacokinetics and antibody-dependent cellular cytotoxicity.
Liljefors M, Nilsson B, Mellstedt H, Frödin JE
Cancer Immunol Immunother 2008 Mar;57(3):379-88. Epub 2007 Aug 4 doi: 10.1007/s00262-007-0377-1. PMID: 17676322Free PMC Article
Phase I and pharmacologic study of a 3-hour infusion of paclitaxel followed by cisplatinum and 5-fluorouracil in patients with advanced solid tumors.
Bhalla KN, Kumar GN, Walle UK, Ibrado AM, Javed T, Stuart RK, Reed C, Arbuck SG, Walle T
Clin Cancer Res 1999 Jul;5(7):1723-30. PMID: 10430075
Evaluation of GM-CSF mouthwash for prevention of chemotherapy-induced mucositis: a randomized, double-blind, dose-ranging study.
Cartee L, Petros WP, Rosner GL, Gilbert C, Moore S, Affronti ML, Hoke JA, Hussein AM, Ross M, Rubin P
Cytokine 1995 Jul;7(5):471-7. doi: 10.1006/cyto.1995.0064. PMID: 7578986
Increased nucleotide catabolism after cerebral convulsions.
Manzke H, Staemmler W, Dörner K
Neuropediatrics 1981 May;12(2):119-31. doi: 10.1055/s-2008-1059645. PMID: 7266776

Diagnosis

Are capecitabine and the active metabolite 5-Fu CNS penetrable to treat breast cancer brain metastasis?
Zhang J, Zhang L, Yan Y, Li S, Xie L, Zhong W, Lv J, Zhang X, Bai Y, Cheng Z
Drug Metab Dispos 2015 Mar;43(3):411-7. Epub 2014 Dec 29 doi: 10.1124/dmd.114.061820. PMID: 25547867
Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma: a pilot study.
Menei P, Venier MC, Gamelin E, Saint-André JP, Hayek G, Jadaud E, Fournier D, Mercier P, Guy G, Benoit JP
Cancer 1999 Jul 15;86(2):325-30. PMID: 10421269

Therapy

Effects and mechanisms of Bazhen decoction, Siwu decoction, and Sijunzi decoction on 5-fluorouracil-induced anemia in mice.
Tian Y, Xiang Y, Wan G, Wan D, Zhu H, Wang T, Yang X
J Tradit Chin Med 2016 Aug;36(4):486-95. doi: 10.1016/s0254-6272(16)30066-8. PMID: 28459513
Are capecitabine and the active metabolite 5-Fu CNS penetrable to treat breast cancer brain metastasis?
Zhang J, Zhang L, Yan Y, Li S, Xie L, Zhong W, Lv J, Zhang X, Bai Y, Cheng Z
Drug Metab Dispos 2015 Mar;43(3):411-7. Epub 2014 Dec 29 doi: 10.1124/dmd.114.061820. PMID: 25547867
Characterization of endogenous G-CSF and the inverse correlation to chemotherapy-induced neutropenia in patients with breast cancer using population modeling.
Quartino AL, Karlsson MO, Lindman H, Friberg LE
Pharm Res 2014 Dec;31(12):3390-403. Epub 2014 Jun 12 doi: 10.1007/s11095-014-1429-9. PMID: 24919931
5-fluorouracil permits access to a primitive subpopulation of peripheral blood stem cells.
Rice A, Barbot C, Lacombe F, Dubosc-Marchenay N, Marit G, Hau F, Boiron JM, Reiffers J
Stem Cells 1993 Jul;11(4):326-35. doi: 10.1002/stem.5530110411. PMID: 8401256
Does the metabolite uracil arabinoside inhibit cytosine arabinoside (Ara-C) penetration into the cerebrospinal fluid during high-dose Ara-C therapy?
van Prooijen HC, Muus P, Roelofs JM, Punt K
Scand J Haematol 1986 Jan;36(1):123-6. doi: 10.1111/j.1600-0609.1986.tb02664.x. PMID: 3456631

Prognosis

Are capecitabine and the active metabolite 5-Fu CNS penetrable to treat breast cancer brain metastasis?
Zhang J, Zhang L, Yan Y, Li S, Xie L, Zhong W, Lv J, Zhang X, Bai Y, Cheng Z
Drug Metab Dispos 2015 Mar;43(3):411-7. Epub 2014 Dec 29 doi: 10.1124/dmd.114.061820. PMID: 25547867
Characterization of endogenous G-CSF and the inverse correlation to chemotherapy-induced neutropenia in patients with breast cancer using population modeling.
Quartino AL, Karlsson MO, Lindman H, Friberg LE
Pharm Res 2014 Dec;31(12):3390-403. Epub 2014 Jun 12 doi: 10.1007/s11095-014-1429-9. PMID: 24919931
Population analysis of the pharmacokinetics and the haematological toxicity of the fluorouracil-epirubicin-cyclophosphamide regimen in breast cancer patients.
Sandström M, Lindman H, Nygren P, Johansson M, Bergh J, Karlsson MO
Cancer Chemother Pharmacol 2006 Aug;58(2):143-56. Epub 2006 Feb 8 doi: 10.1007/s00280-005-0140-2. PMID: 16465545
Phase I and pharmacologic study of a 3-hour infusion of paclitaxel followed by cisplatinum and 5-fluorouracil in patients with advanced solid tumors.
Bhalla KN, Kumar GN, Walle UK, Ibrado AM, Javed T, Stuart RK, Reed C, Arbuck SG, Walle T
Clin Cancer Res 1999 Jul;5(7):1723-30. PMID: 10430075

Clinical prediction guides

Effects and mechanisms of Bazhen decoction, Siwu decoction, and Sijunzi decoction on 5-fluorouracil-induced anemia in mice.
Tian Y, Xiang Y, Wan G, Wan D, Zhu H, Wang T, Yang X
J Tradit Chin Med 2016 Aug;36(4):486-95. doi: 10.1016/s0254-6272(16)30066-8. PMID: 28459513
Are capecitabine and the active metabolite 5-Fu CNS penetrable to treat breast cancer brain metastasis?
Zhang J, Zhang L, Yan Y, Li S, Xie L, Zhong W, Lv J, Zhang X, Bai Y, Cheng Z
Drug Metab Dispos 2015 Mar;43(3):411-7. Epub 2014 Dec 29 doi: 10.1124/dmd.114.061820. PMID: 25547867
Influence of varying doses of granulocyte-macrophage colony-stimulating factor on pharmacokinetics and antibody-dependent cellular cytotoxicity.
Liljefors M, Nilsson B, Mellstedt H, Frödin JE
Cancer Immunol Immunother 2008 Mar;57(3):379-88. Epub 2007 Aug 4 doi: 10.1007/s00262-007-0377-1. PMID: 17676322Free PMC Article
A near homoplasmic T8993G mtDNA mutation in a patient with atypic Leigh syndrome not present in the mother's tissues.
Degoul F, François D, Diry M, Ponsot G, Desguerre I, Héron B, Marsac C, Moutard ML
J Inherit Metab Dis 1997 Mar;20(1):49-53. doi: 10.1023/a:1005357506614. PMID: 9061567
5-fluorouracil permits access to a primitive subpopulation of peripheral blood stem cells.
Rice A, Barbot C, Lacombe F, Dubosc-Marchenay N, Marit G, Hau F, Boiron JM, Reiffers J
Stem Cells 1993 Jul;11(4):326-35. doi: 10.1002/stem.5530110411. PMID: 8401256

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