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Reduced intraepidermal small nerve fiber density

MedGen UID:
1841878
Concept ID:
C5826821
Finding
HPO: HP:0034997

Definition

Reduced number of small nerve fibers in the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced intraepidermal small nerve fiber density

Professional guidelines

PubMed

Chao CC, Hsieh PC, Janice Lin CH, Huang SL, Hsieh ST, Chiang MC
Ann Neurol 2023 Apr;93(4):655-667. Epub 2022 Dec 28 doi: 10.1002/ana.26577. PMID: 36511844
Lamotte G, Sandroni P
Curr Neurol Neurosci Rep 2022 Dec;22(12):823-837. Epub 2022 Nov 15 doi: 10.1007/s11910-022-01240-4. PMID: 36376534Free PMC Article
Haroutounian S, Todorovic MS, Leinders M, Campagnolo M, Gewandter JS, Dworkin RH, Freeman R
Muscle Nerve 2021 Feb;63(2):170-177. Epub 2020 Sep 29 doi: 10.1002/mus.27070. PMID: 32989823

Recent clinical studies

Etiology

Løseth S, Nebuchennykh M, Brokstad RT, Lindal S, Mellgren SI
Scand J Pain 2024 Jan 1;24(1) Epub 2024 Feb 22 doi: 10.1515/sjpain-2023-0071. PMID: 38381703
Dhanapalaratnam R, Issar T, Lee ATK, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Diabetologia 2024 Mar;67(3):561-566. Epub 2024 Jan 8 doi: 10.1007/s00125-023-06072-6. PMID: 38189936
Chien YL, Chao CC, Wu SW, Hsueh HW, Chiu YN, Tsai WC, Gau SS, Hsieh ST
Neurology 2020 Nov 10;95(19):e2697-e2706. Epub 2020 Oct 14 doi: 10.1212/WNL.0000000000010932. PMID: 33055277
Rasmussen VF, Karlsson P, Drummond PD, Schaldemose EL, Terkelsen AJ, Jensen TS, Knudsen LF
Pain Med 2018 Oct 1;19(10):2021-2030. doi: 10.1093/pm/pnx240. PMID: 30299507
Bednarik J, Vlckova-Moravcova E, Bursova S, Belobradkova J, Dusek L, Sommer C
J Peripher Nerv Syst 2009 Sep;14(3):177-83. doi: 10.1111/j.1529-8027.2009.00229.x. PMID: 19909481

Diagnosis

Lamotte G, Sandroni P
Curr Neurol Neurosci Rep 2022 Dec;22(12):823-837. Epub 2022 Nov 15 doi: 10.1007/s11910-022-01240-4. PMID: 36376534Free PMC Article
Wong LS, Lee CH, Yen YT
Int J Mol Sci 2022 Aug 12;23(16) doi: 10.3390/ijms23169030. PMID: 36012289Free PMC Article
Finsterer J, Scorza FA
Acta Neurol Scand 2022 May;145(5):493-503. Epub 2022 Feb 7 doi: 10.1111/ane.13591. PMID: 35130356
Rasmussen VF, Karlsson P, Drummond PD, Schaldemose EL, Terkelsen AJ, Jensen TS, Knudsen LF
Pain Med 2018 Oct 1;19(10):2021-2030. doi: 10.1093/pm/pnx240. PMID: 30299507
Tavee JO
Cleve Clin J Med 2018 Oct;85(10):801-812. doi: 10.3949/ccjm.85a.17124. PMID: 30289758

Therapy

Dhanapalaratnam R, Issar T, Lee ATK, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Diabetologia 2024 Mar;67(3):561-566. Epub 2024 Jan 8 doi: 10.1007/s00125-023-06072-6. PMID: 38189936
Albayrak M, Figueras C, Seguí E, Campolo M, Gabarrón E, Moreno R, Maurel J, Casanova-Molla J
J Neurol 2022 Aug;269(8):4174-4184. Epub 2022 Mar 8 doi: 10.1007/s00415-022-11035-9. PMID: 35258850Free PMC Article
Finsterer J, Scorza FA
Acta Neurol Scand 2022 May;145(5):493-503. Epub 2022 Feb 7 doi: 10.1111/ane.13591. PMID: 35130356
Nolano M, Provitera V, Manganelli F, Iodice R, Stancanelli A, Caporaso G, Saltalamacchia A, Califano F, Lanzillo B, Picillo M, Barone P, Santoro L
Neurology 2017 Aug 22;89(8):776-784. Epub 2017 Jul 26 doi: 10.1212/WNL.0000000000004274. PMID: 28747449
Koskinen MJ, Kautio AL, Haanpää ML, Haapasalo HK, Kellokumpu-Lehtinen PL, Saarto T, Hietaharju AJ
Anticancer Res 2011 Dec;31(12):4413-6. PMID: 22199308

Prognosis

Dhanapalaratnam R, Issar T, Lee ATK, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Diabetologia 2024 Mar;67(3):561-566. Epub 2024 Jan 8 doi: 10.1007/s00125-023-06072-6. PMID: 38189936
Albayrak M, Figueras C, Seguí E, Campolo M, Gabarrón E, Moreno R, Maurel J, Casanova-Molla J
J Neurol 2022 Aug;269(8):4174-4184. Epub 2022 Mar 8 doi: 10.1007/s00415-022-11035-9. PMID: 35258850Free PMC Article
Özdağ Acarlı AN, Klein T, Egenolf N, Sommer C, Üçeyler N
Muscle Nerve 2022 Apr;65(4):471-479. Epub 2022 Jan 26 doi: 10.1002/mus.27496. PMID: 35020203
Descamps E, Henry J, Labeyrie C, Adams D, Ghaidaa AN, Vandendries C, Adam C, Aiello D, Mariette X, Seror R
Muscle Nerve 2020 Apr;61(4):515-520. Epub 2020 Feb 15 doi: 10.1002/mus.26824. PMID: 32012291
Schrempf W, Katona I, Dogan I, Felbert VV, Wienecke M, Heller J, Maier A, Hermann A, Linse K, Brandt MD, Reichmann H, Schulz JB, Schiefer J, Oertel WH, Storch A, Weis J, Reetz K
Parkinsonism Relat Disord 2016 Aug;29:10-6. Epub 2016 Jun 6 doi: 10.1016/j.parkreldis.2016.06.003. PMID: 27318706

Clinical prediction guides

Løseth S, Nebuchennykh M, Brokstad RT, Lindal S, Mellgren SI
Scand J Pain 2024 Jan 1;24(1) Epub 2024 Feb 22 doi: 10.1515/sjpain-2023-0071. PMID: 38381703
Dhanapalaratnam R, Issar T, Lee ATK, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Diabetologia 2024 Mar;67(3):561-566. Epub 2024 Jan 8 doi: 10.1007/s00125-023-06072-6. PMID: 38189936
Chao CC, Hsieh PC, Janice Lin CH, Huang SL, Hsieh ST, Chiang MC
Ann Neurol 2023 Apr;93(4):655-667. Epub 2022 Dec 28 doi: 10.1002/ana.26577. PMID: 36511844
Albayrak M, Figueras C, Seguí E, Campolo M, Gabarrón E, Moreno R, Maurel J, Casanova-Molla J
J Neurol 2022 Aug;269(8):4174-4184. Epub 2022 Mar 8 doi: 10.1007/s00415-022-11035-9. PMID: 35258850Free PMC Article
Chien YL, Chao CC, Wu SW, Hsueh HW, Chiu YN, Tsai WC, Gau SS, Hsieh ST
Neurology 2020 Nov 10;95(19):e2697-e2706. Epub 2020 Oct 14 doi: 10.1212/WNL.0000000000010932. PMID: 33055277

Recent systematic reviews

Haroutounian S, Todorovic MS, Leinders M, Campagnolo M, Gewandter JS, Dworkin RH, Freeman R
Muscle Nerve 2021 Feb;63(2):170-177. Epub 2020 Sep 29 doi: 10.1002/mus.27070. PMID: 32989823
Bakkers M, Faber CG, Peters MJ, Reulen JP, Franssen H, Fischer TZ, Merkies IS
J Peripher Nerv Syst 2013 Mar;18(1):7-18. doi: 10.1111/jns5.12001. PMID: 23521638

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