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Extreme oligozoospermia

MedGen UID:
1841778
•Concept ID:
C5826680
•
Disease or Syndrome
HPO: HP:0034815

Definition

A type of oligozoospermia characterized by a total number of more than zero but less than 2 million sperm in the ejaculate or a concentration of more than zero but less than one million sperm per milliliter. [from HPO]

Professional guidelines

PubMed

Effect of modifiable lifestyle factors and antioxidant treatment on semen parameters of men with severe oligoasthenoteratozoospermia.
Magdi Y, Darwish E, Elbashir S, Majzoub A, Agarwal A
Andrologia 2017 Sep;49(7) Epub 2016 Nov 10 doi: 10.1111/and.12694. PMID: 27859525
Treatment of male infertility.
Check JH
Clin Exp Obstet Gynecol 2007;34(4):201-6. PMID: 18225678
Is the subzonal-insemination procedure an efficient technique in the treatment of extreme oligoasthenoteratozoospermia?
Bertrand E, Devreker F, van den Bergh M, Englert Y
Eur J Morphol 1996 Nov;34(4):245-55. doi: 10.1076/ejom.34.4.245.13042. PMID: 8982634

Recent clinical studies

Etiology

Sequential interval micro-droplet loading in closed hemi-straw carrier system: A convenient and efficient method for ultra-rapid cryopreservation in extreme oligozoospermia.
Huang WJ, Zhang D, Hong ZW, Chen ZB, Dong LH, Zhang Y, Chen GY, Liu Y, Yao B
Cryobiology 2020 Apr;93:75-83. Epub 2020 Feb 11 doi: 10.1016/j.cryobiol.2020.02.005. PMID: 32057735
Extreme spermatogenesis failure: andrological phenotype and intracytoplasmic sperm injection outcomes.
Plouvier P, Barbotin AL, Boitrelle F, Dewailly D, Mitchell V, Rigot JM, Lefebvre-Khalil V, Robin G
Andrology 2017 Mar;5(2):219-225. Epub 2017 Feb 10 doi: 10.1111/andr.12323. PMID: 28187504
The value of chromosomal analysis in oligozoospermic men.
Stegen Ç, van Rumste MM, Mol BW, Koks CA
Fertil Steril 2012 Dec;98(6):1438-42. Epub 2012 Sep 6 doi: 10.1016/j.fertnstert.2012.08.005. PMID: 22959453
Optimal management of extreme oligozoospermia by an appropriate cryopreservation programme.
Koscinski I, Wittemer C, Lefebvre-Khalil V, Marcelli F, Defossez A, Rigot JM
Hum Reprod 2007 Oct;22(10):2679-84. Epub 2007 Aug 1 doi: 10.1093/humrep/dem190. PMID: 17673455
Genetic risk factors in infertile men with severe oligozoospermia and azoospermia.
Dohle GR, Halley DJ, Van Hemel JO, van den Ouwel AM, Pieters MH, Weber RF, Govaerts LC
Hum Reprod 2002 Jan;17(1):13-6. doi: 10.1093/humrep/17.1.13. PMID: 11756355

Diagnosis

The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.
Wyrwoll MJ, Gaasbeek CM, Golubickaite I, Stakaitis R, Oud MS, Nagirnaja L, Dion C, Sindi EB, Leitch HG, Jayasena CN, Sironen A, Dicke AK, Rotte N, Stallmeyer B, Kliesch S, Grangeiro CHP, Araujo TF, Lasko P; Genetics of Male Infertility Initiative (GEMINI) consortium, D'Hauwers K, Smits RM, Ramos L, Xavier MJ, Conrad DF, Almstrup K, Veltman JA, Tüttelmann F, van der Heijden GW
Am J Hum Genet 2022 Oct 6;109(10):1850-1866. Epub 2022 Sep 22 doi: 10.1016/j.ajhg.2022.09.002. PMID: 36150389Free PMC Article
Sperm and assisted reproduction.
Tournaye H
Minerva Urol Nefrol 2005 Jun;57(2):91-7. PMID: 15951733
Validation of a simple Yq deletion screening programme in an ICSI candidate population.
Van Landuyt L, Lissens W, Stouffs K, Tournaye H, Liebaers I, Van Steirteghem A
Mol Hum Reprod 2000 Apr;6(4):291-7. doi: 10.1093/molehr/6.4.291. PMID: 10729309
Male fertility disorders.
Hargreave T, Ghosh C
Endocrinol Metab Clin North Am 1998 Dec;27(4):765-82, vii-viii. doi: 10.1016/s0889-8529(05)70040-2. PMID: 9922907

Therapy

Optimal management of extreme oligozoospermia by an appropriate cryopreservation programme.
Koscinski I, Wittemer C, Lefebvre-Khalil V, Marcelli F, Defossez A, Rigot JM
Hum Reprod 2007 Oct;22(10):2679-84. Epub 2007 Aug 1 doi: 10.1093/humrep/dem190. PMID: 17673455
First experience with intracytoplasmic sperm injection for extreme oligozoospermia associated with Crohn's disease and 6-mercaptopurine chemotherapy.
Sills ES, Tucker MJ
Asian J Androl 2003 Mar;5(1):76-8. PMID: 12647009
Gamete intra-fallopian transfer with cryopreserved donor semen following AID failure.
Pilikian S, Watrelot A, Dreyfus JM, Ecochard R, Gennaro JD
Hum Reprod 1990 Nov;5(8):944-6. doi: 10.1093/oxfordjournals.humrep.a137225. PMID: 2081805
Enhanced serum prolactin concentration after metoclopramide stimulation in idiopathic oligozoospermia and azoospermia.
Baranowska B, Jeske W, Niewiadomska A, Rozbicka G, Walczak L, Zgliczynski S
Andrologia 1983;15 Spec No:554-9. doi: 10.1111/j.1439-0272.1983.tb00211.x. PMID: 6421192

Prognosis

The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.
Wyrwoll MJ, Gaasbeek CM, Golubickaite I, Stakaitis R, Oud MS, Nagirnaja L, Dion C, Sindi EB, Leitch HG, Jayasena CN, Sironen A, Dicke AK, Rotte N, Stallmeyer B, Kliesch S, Grangeiro CHP, Araujo TF, Lasko P; Genetics of Male Infertility Initiative (GEMINI) consortium, D'Hauwers K, Smits RM, Ramos L, Xavier MJ, Conrad DF, Almstrup K, Veltman JA, Tüttelmann F, van der Heijden GW
Am J Hum Genet 2022 Oct 6;109(10):1850-1866. Epub 2022 Sep 22 doi: 10.1016/j.ajhg.2022.09.002. PMID: 36150389Free PMC Article
First experience with intracytoplasmic sperm injection for extreme oligozoospermia associated with Crohn's disease and 6-mercaptopurine chemotherapy.
Sills ES, Tucker MJ
Asian J Androl 2003 Mar;5(1):76-8. PMID: 12647009

Clinical prediction guides

The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.
Wyrwoll MJ, Gaasbeek CM, Golubickaite I, Stakaitis R, Oud MS, Nagirnaja L, Dion C, Sindi EB, Leitch HG, Jayasena CN, Sironen A, Dicke AK, Rotte N, Stallmeyer B, Kliesch S, Grangeiro CHP, Araujo TF, Lasko P; Genetics of Male Infertility Initiative (GEMINI) consortium, D'Hauwers K, Smits RM, Ramos L, Xavier MJ, Conrad DF, Almstrup K, Veltman JA, Tüttelmann F, van der Heijden GW
Am J Hum Genet 2022 Oct 6;109(10):1850-1866. Epub 2022 Sep 22 doi: 10.1016/j.ajhg.2022.09.002. PMID: 36150389Free PMC Article
Clinical data and parenthood of 63 infertile and Y-microdeleted men.
Patrat C, Bienvenu T, Janny L, Faure AK, Fauque P, Aknin-Seifer I, Davy C, Thiounn N, Jouannet P, Lévy R
Fertil Steril 2010 Feb;93(3):822-32. Epub 2008 Dec 4 doi: 10.1016/j.fertnstert.2008.10.033. PMID: 19062004
The testicular biopsy and spermatogenesis disturbance of infertile patients with bilateral varicocele.
Tchovelidze C, Sibony M, Callard P, Guetta T, Lababidi H, Arvis G
Arkh Patol 2004 Mar-Apr;66(2):40-5. PMID: 15154383

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