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CSF mycobacteria

MedGen UID:
1841732
•Concept ID:
C5826637
•
Finding
HPO: HP:0034748

Definition

Mycobacterium present in the cerebrospinal fluid (CSF). This feature can be ascertained by CSF microscopy. [from HPO]

Professional guidelines

PubMed

Tuberculous meningitis in children: Clinical management & outcome.
Daniel BD, Grace GA, Natrajan M
Indian J Med Res 2019 Aug;150(2):117-130. doi: 10.4103/ijmr.IJMR_786_17. PMID: 31670267Free PMC Article
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, Innes J; British Infection Society
J Infect 2009 Sep;59(3):167-87. Epub 2009 Jul 4 doi: 10.1016/j.jinf.2009.06.011. PMID: 19643501
Tuberculous meningitis: does lowering the treatment threshold result in many more treated patients?
Moreira J, Alarcon F, Bisoffi Z, Rivera J, Salinas R, Menten J, Dueñas G, Van den Ende J
Trop Med Int Health 2008 Jan;13(1):68-75. doi: 10.1111/j.1365-3156.2007.01975.x. PMID: 18291004

Recent clinical studies

Etiology

Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview.
Arts RJW, Janssen NAF, van de Veerdonk FL
Int J Mol Sci 2023 Dec 30;25(1) doi: 10.3390/ijms25010515. PMID: 38203686Free PMC Article
Escalate: Linezolid as an add on treatment in the intensive phase of tubercular meningitis. A randomized controlled pilot trial.
Sahib A, Bhatia R, Srivastava MVP, Singh MB, Komakula S, Vishnu VY, Rajan R, Gupta A, Srivastava AK, Wig N, Vikram NK, Biswas A
Tuberculosis (Edinb) 2023 Sep;142:102351. Epub 2023 Jun 30 doi: 10.1016/j.tube.2023.102351. PMID: 37394301
Neurotuberculosis: an update.
Cherian A, Ajitha KC, Iype T, Divya KP
Acta Neurol Belg 2021 Feb;121(1):11-21. Epub 2021 Jan 5 doi: 10.1007/s13760-020-01575-0. PMID: 33400226
Tuberculous meningitis in children: Clinical management & outcome.
Daniel BD, Grace GA, Natrajan M
Indian J Med Res 2019 Aug;150(2):117-130. doi: 10.4103/ijmr.IJMR_786_17. PMID: 31670267Free PMC Article
Central nervous system tuberculosis.
Cherian A, Thomas SV
Afr Health Sci 2011 Mar;11(1):116-27. PMID: 21572867Free PMC Article

Diagnosis

Tuberculous meningitis: progress and remaining questions.
Huynh J, Donovan J, Phu NH, Nghia HDT, Thuong NTT, Thwaites GE
Lancet Neurol 2022 May;21(5):450-464. doi: 10.1016/S1474-4422(21)00435-X. PMID: 35429482
Neurotuberculosis: an update.
Cherian A, Ajitha KC, Iype T, Divya KP
Acta Neurol Belg 2021 Feb;121(1):11-21. Epub 2021 Jan 5 doi: 10.1007/s13760-020-01575-0. PMID: 33400226
Tuberculous meningitis: where to from here?
Donovan J, Thwaites GE, Huynh J
Curr Opin Infect Dis 2020 Jun;33(3):259-266. doi: 10.1097/QCO.0000000000000648. PMID: 32324614Free PMC Article
Advances in the Diagnosis and Management of Tubercular Meningitis in Children.
Bhasin H, Goyal M, Sharma S
Indian J Pediatr 2020 Jan;87(1):26-33. Epub 2019 Dec 4 doi: 10.1007/s12098-019-03089-x. PMID: 31802325
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443

Therapy

Tuberculous meningitis: progress and remaining questions.
Huynh J, Donovan J, Phu NH, Nghia HDT, Thuong NTT, Thwaites GE
Lancet Neurol 2022 May;21(5):450-464. doi: 10.1016/S1474-4422(21)00435-X. PMID: 35429482
Tuberculous meningitis: where to from here?
Donovan J, Thwaites GE, Huynh J
Curr Opin Infect Dis 2020 Jun;33(3):259-266. doi: 10.1097/QCO.0000000000000648. PMID: 32324614Free PMC Article
Beyond antibiotics for pulmonary nontuberculous mycobacterial disease.
Waterer G
Curr Opin Pulm Med 2020 May;26(3):260-266. doi: 10.1097/MCP.0000000000000665. PMID: 32101903
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Central nervous system tuberculosis.
Cherian A, Thomas SV
Afr Health Sci 2011 Mar;11(1):116-27. PMID: 21572867Free PMC Article

Prognosis

Performance of Xpert(®) MTB/RIF and Xpert(®) Ultra for the diagnosis of tuberculous meningitis in children.
Pradhan NN, Paradkar MS, Kagal A, Valvi C, Kinikar A, Khwaja S, Dhage R, Chandane J, Ithape M, Bendre M, Madewar R, Nadgeri V, Nijampurkar A, Jain D, Gupte N, Gupta A, Mave V, Dooley KE, Thakur KT
Int J Tuberc Lung Dis 2022 Apr 1;26(4):317-325. doi: 10.5588/ijtld.21.0388. PMID: 35351236Free PMC Article
Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality.
Koeken VACM, Ganiem AR, Dian S, Ruslami R, Chaidir L, Netea MG, Kumar V, Alisjahbana B, van Crevel R, van Laarhoven A
Tuberculosis (Edinb) 2021 Jan;126:102019. Epub 2020 Nov 11 doi: 10.1016/j.tube.2020.102019. PMID: 33202351
Pulmonary alveolar proteinosis.
Jouneau S, Ménard C, Lederlin M
Respirology 2020 Aug;25(8):816-826. Epub 2020 May 3 doi: 10.1111/resp.13831. PMID: 32363736
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Tuberculous meningitis.
Kennedy DH, Fallon RJ
JAMA 1979 Jan 19;241(3):264-8. PMID: 102806

Clinical prediction guides

Escalate: Linezolid as an add on treatment in the intensive phase of tubercular meningitis. A randomized controlled pilot trial.
Sahib A, Bhatia R, Srivastava MVP, Singh MB, Komakula S, Vishnu VY, Rajan R, Gupta A, Srivastava AK, Wig N, Vikram NK, Biswas A
Tuberculosis (Edinb) 2023 Sep;142:102351. Epub 2023 Jun 30 doi: 10.1016/j.tube.2023.102351. PMID: 37394301
Extracellular Matrix-Induced GM-CSF and Hypoxia Promote Immune Control of Mycobacterium tuberculosis in Human In Vitro Granulomas.
Arbués A, Schmidiger S, Kammüller M, Portevin D
Front Immunol 2021;12:727508. Epub 2021 Sep 17 doi: 10.3389/fimmu.2021.727508. PMID: 34603299Free PMC Article
Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality.
Koeken VACM, Ganiem AR, Dian S, Ruslami R, Chaidir L, Netea MG, Kumar V, Alisjahbana B, van Crevel R, van Laarhoven A
Tuberculosis (Edinb) 2021 Jan;126:102019. Epub 2020 Nov 11 doi: 10.1016/j.tube.2020.102019. PMID: 33202351
Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward.
Donovan J, Cresswell FV, Thuong NTT, Boulware DR, Thwaites GE, Bahr NC; Tuberculous Meningitis International Research Consortium
Clin Infect Dis 2020 Nov 5;71(8):2002-2005. doi: 10.1093/cid/ciaa473. PMID: 32543658Free PMC Article
Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid.
Mason S, Reinecke CJ, Kulik W, van Cruchten A, Solomons R, van Furth AM
BMC Infect Dis 2016 Jun 7;16:251. doi: 10.1186/s12879-016-1597-9. PMID: 27267176Free PMC Article

Recent systematic reviews

Microbiological diagnosis and mortality of tuberculosis meningitis: Systematic review and meta-analysis.
Seid G, Alemu A, Dagne B, Gamtesa DF
PLoS One 2023;18(2):e0279203. Epub 2023 Feb 16 doi: 10.1371/journal.pone.0279203. PMID: 36795648Free PMC Article
Central Inflammatory Cytokines in Tuberculous Meningitis: A Systematic Review and Meta-analysis.
Saghazadeh A, Rezaei N
J Interferon Cytokine Res 2022 Mar;42(3):95-107. doi: 10.1089/jir.2021.0176. PMID: 35298290
Treatment outcomes of tuberculous meningitis in adults: a systematic review and meta-analysis.
Wang MG, Luo L, Zhang Y, Liu X, Liu L, He JQ
BMC Pulm Med 2019 Nov 6;19(1):200. doi: 10.1186/s12890-019-0966-8. PMID: 31694599Free PMC Article
Antibody detection tests for early diagnosis in tuberculous meningitis.
Huang TY, Zhang XX, Wu QL, Peng WG, Zheng GL, Cai YM, Pang MC, Wu YE
Int J Infect Dis 2016 Jul;48:64-9. Epub 2016 May 9 doi: 10.1016/j.ijid.2016.05.007. PMID: 27173078
Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis.
Chiang SS, Khan FA, Milstein MB, Tolman AW, Benedetti A, Starke JR, Becerra MC
Lancet Infect Dis 2014 Oct;14(10):947-57. Epub 2014 Aug 6 doi: 10.1016/S1473-3099(14)70852-7. PMID: 25108337

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