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Increased CSF taurine concentration

MedGen UID:
1841698
•Concept ID:
C5826405
•
Finding
Synonym: Taurine high in CSF
 
HPO: HP:0034455

Definition

Increased concentration of taurine in the cerebrospinal fluid (CSF). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased CSF taurine concentration

Professional guidelines

PubMed

Inhibitory and excitatory amino acids in CSF of patients suffering from complex partial seizures during chronic treatment with gamma-vinyl GABA (vigabatrin).
Halonen T, Lehtinen M, Pitkänen A, Ylinen A, Riekkinen PJ
Epilepsy Res 1988 Jul-Aug;2(4):246-52. doi: 10.1016/0920-1211(88)90015-0. PMID: 3143562

Recent clinical studies

Etiology

Toxic levels of ammonia in human brain abscess.
Dahlberg D, Ivanovic J, Hassel B
J Neurosurg 2016 Mar;124(3):854-60. Epub 2015 Aug 14 doi: 10.3171/2015.1.JNS142582. PMID: 26274996
Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients.
Westhoff D, Witlox J, Koenderman L, Kalisvaart KJ, de Jonghe JF, van Stijn MF, Houdijk AP, Hoogland IC, Maclullich AM, van Westerloo DJ, van de Beek D, Eikelenboom P, van Gool WA
J Neuroinflammation 2013 Oct 7;10:122. doi: 10.1186/1742-2094-10-122. PMID: 24093540Free PMC Article
Post-operative monitoring of cortical taurine in patients with subarachnoid hemorrhage: a microdialysis study.
De Micheli E, Pinna G, Alfieri A, Caramia G, Bianchi L, Colivicchi MA, Della Corte L, Bricolo A
Adv Exp Med Biol 2000;483:595-603. doi: 10.1007/0-306-46838-7_64. PMID: 11787646
Cholesterol esterase activity in cerebrospinal fluid of multiple sclerosis patients.
Pitkänen AS, Halonen TO, Kilpeläinen HO, Riekkinen PJ
J Neurol Sci 1986 Jun;74(1):45-53. doi: 10.1016/0022-510x(86)90190-5. PMID: 3723135
Increased levels of amino acids in human lumbar and central cerebrospinal fluid after subarachnoid haemorrhage.
von Holst H, Hagenfeldt L
Acta Neurochir (Wien) 1985;78(1-2):46-56. doi: 10.1007/BF01809241. PMID: 4072793

Diagnosis

Measurement of Hypothalamic Glucose Under Euglycemia and Hyperglycemia by MRI at 3T.
Joers JM, Deelchand DK, Kumar A, Moheet A, Seaquist E, Henry PG, Öz G
J Magn Reson Imaging 2017 Mar;45(3):681-691. Epub 2016 Jul 12 doi: 10.1002/jmri.25383. PMID: 27402249Free PMC Article
Toxic levels of ammonia in human brain abscess.
Dahlberg D, Ivanovic J, Hassel B
J Neurosurg 2016 Mar;124(3):854-60. Epub 2015 Aug 14 doi: 10.3171/2015.1.JNS142582. PMID: 26274996
Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients.
Westhoff D, Witlox J, Koenderman L, Kalisvaart KJ, de Jonghe JF, van Stijn MF, Houdijk AP, Hoogland IC, Maclullich AM, van Westerloo DJ, van de Beek D, Eikelenboom P, van Gool WA
J Neuroinflammation 2013 Oct 7;10:122. doi: 10.1186/1742-2094-10-122. PMID: 24093540Free PMC Article
Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).
Kay GW, Verbeek MM, Furlong JM, Willemsen MA, Palmer DN
Neurochem Int 2009 Dec;55(8):783-8. Epub 2009 Aug 5 doi: 10.1016/j.neuint.2009.07.012. PMID: 19664668Free PMC Article
Post-operative monitoring of cortical taurine in patients with subarachnoid hemorrhage: a microdialysis study.
De Micheli E, Pinna G, Alfieri A, Caramia G, Bianchi L, Colivicchi MA, Della Corte L, Bricolo A
Adv Exp Med Biol 2000;483:595-603. doi: 10.1007/0-306-46838-7_64. PMID: 11787646

Therapy

Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients.
Westhoff D, Witlox J, Koenderman L, Kalisvaart KJ, de Jonghe JF, van Stijn MF, Houdijk AP, Hoogland IC, Maclullich AM, van Westerloo DJ, van de Beek D, Eikelenboom P, van Gool WA
J Neuroinflammation 2013 Oct 7;10:122. doi: 10.1186/1742-2094-10-122. PMID: 24093540Free PMC Article
Taurine exerts robust protection against hypoxia and oxygen/glucose deprivation in human neuroblastoma cell culture.
Chen PC, Pan C, Gharibani PM, Prentice H, Wu JY
Adv Exp Med Biol 2013;775:167-75. doi: 10.1007/978-1-4614-6130-2_14. PMID: 23392933
Inhibitory and excitatory amino acids in CSF of patients suffering from complex partial seizures during chronic treatment with gamma-vinyl GABA (vigabatrin).
Halonen T, Lehtinen M, Pitkänen A, Ylinen A, Riekkinen PJ
Epilepsy Res 1988 Jul-Aug;2(4):246-52. doi: 10.1016/0920-1211(88)90015-0. PMID: 3143562
Therapeutic trial by taurine for intractable childhood epilepsies.
Fukuyama Y, Ochiai Y
Brain Dev 1982;4(1):63-9. doi: 10.1016/s0387-7604(82)80103-4. PMID: 7039391
Biochemical observations following administration of taurine to patients with epilepsy.
Van Gelder NM, Sherwin AL, Sacks C, Anderman F
Brain Res 1975 Aug 29;94(2):297-306. doi: 10.1016/0006-8993(75)90063-3. PMID: 807299

Prognosis

Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).
Kay GW, Verbeek MM, Furlong JM, Willemsen MA, Palmer DN
Neurochem Int 2009 Dec;55(8):783-8. Epub 2009 Aug 5 doi: 10.1016/j.neuint.2009.07.012. PMID: 19664668Free PMC Article
Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways.
Larson AA, Giovengo SL, Russell JI, Michalek JE
Pain 2000 Aug;87(2):201-211. doi: 10.1016/S0304-3959(00)00284-0. PMID: 10924813
Cholesterol esterase activity in cerebrospinal fluid of multiple sclerosis patients.
Pitkänen AS, Halonen TO, Kilpeläinen HO, Riekkinen PJ
J Neurol Sci 1986 Jun;74(1):45-53. doi: 10.1016/0022-510x(86)90190-5. PMID: 3723135
Therapeutic trial by taurine for intractable childhood epilepsies.
Fukuyama Y, Ochiai Y
Brain Dev 1982;4(1):63-9. doi: 10.1016/s0387-7604(82)80103-4. PMID: 7039391

Clinical prediction guides

Effect of blood contamination of cerebrospinal fluid on amino acids, biogenic amines, pterins and vitamins.
Batllori M, Casado M, Sierra C, Salgado MDC, Marti-Sanchez L, Maynou J, Fernandez G, Garcia-Cazorla A, Ormazabal A, Molero-Luis M, Artuch R
Fluids Barriers CNS 2019 Nov 14;16(1):34. doi: 10.1186/s12987-019-0154-5. PMID: 31727079Free PMC Article
Measurement of Hypothalamic Glucose Under Euglycemia and Hyperglycemia by MRI at 3T.
Joers JM, Deelchand DK, Kumar A, Moheet A, Seaquist E, Henry PG, Öz G
J Magn Reson Imaging 2017 Mar;45(3):681-691. Epub 2016 Jul 12 doi: 10.1002/jmri.25383. PMID: 27402249Free PMC Article
Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).
Kay GW, Verbeek MM, Furlong JM, Willemsen MA, Palmer DN
Neurochem Int 2009 Dec;55(8):783-8. Epub 2009 Aug 5 doi: 10.1016/j.neuint.2009.07.012. PMID: 19664668Free PMC Article
Cerebrospinal fluid taurine after traumatic brain injury.
Seki Y, Kimura M, Mizutani N, Fujita M, Aimi Y, Suzuki Y
Neurochem Res 2005 Jan;30(1):123-8. doi: 10.1007/s11064-004-9693-4. PMID: 15756940
Post-operative monitoring of cortical taurine in patients with subarachnoid hemorrhage: a microdialysis study.
De Micheli E, Pinna G, Alfieri A, Caramia G, Bianchi L, Colivicchi MA, Della Corte L, Bricolo A
Adv Exp Med Biol 2000;483:595-603. doi: 10.1007/0-306-46838-7_64. PMID: 11787646

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