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Reduced fibroblast type III procollagen synthesis

MedGen UID:
1841622
•Concept ID:
C5826452
•
Cell or Molecular Dysfunction
Synonym: Type III procollagen synthesis by fibroblasts low
 
HPO: HP:0034528

Definition

Diminished production of type III procollagen by cultured skin fibroblasts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced fibroblast type III procollagen synthesis

Professional guidelines

PubMed

Fibroblast Activation Protein is a GH Target: A Prospective Study of Patients with Acromegaly Before and After Treatment.
Arlien-Søborg MC, Grøndahl C, Bæk A, Dal J, Madsen M, Høgild ML, Pedersen SB, Bjerre M, Jørgensen JOL
J Clin Endocrinol Metab 2020 Jan 1;105(1) doi: 10.1210/clinem/dgz033. PMID: 31544947
Effect of integrin β1 in the treatment of stress urinary incontinence by electrical stimulation.
Li Y, Li BS, Liu C, Hong SS, Min J, Hu M, Tang JM, Li ST, Wang TT, Zhou HX, Hong L
Mol Med Rep 2019 Jun;19(6):4727-4734. Epub 2019 Apr 10 doi: 10.3892/mmr.2019.10145. PMID: 31059065Free PMC Article
Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis.
Watson CJ, Horgan S, Neary R, Glezeva N, Tea I, Corrigan N, McDonald K, Ledwidge M, Baugh J
J Cardiovasc Pharmacol Ther 2016 Jan;21(1):127-37. Epub 2015 Jun 30 doi: 10.1177/1074248415591698. PMID: 26130616

Recent clinical studies

Etiology

Cathelicidin LL-37 Expression in Human Breast Implant Capsules.
Segreto F, Carotti S, Marangi GF, Francesconi M, Calia E, Cagli B, Cimmino A, Rossi C, Morini S, Persichetti P
Plast Reconstr Surg 2024 May 1;153(5):1066-1073. Epub 2023 May 22 doi: 10.1097/PRS.0000000000010733. PMID: 37220260
Endogenous Modulation of Extracellular Matrix Collagen during Scar Formation after Myocardial Infarction.
Schumacher D, Curaj A, Staudt M, Simsekyilmaz S, Kanzler I, Boor P, Klinkhammer BM, Li X, Bucur O, Kaabi A, Xu Y, Zheng H, Nilcham P, Schuh A, Rusu M, Liehn EA
Int J Mol Sci 2022 Nov 23;23(23) doi: 10.3390/ijms232314571. PMID: 36498897Free PMC Article
The anti-scarring role of Lycium barbarum polysaccharide on cornea epithelial-stromal injury.
Wong HL, Hung LT, Kwok SS, Bu Y, Lin Y, Shum HC, Wang H, Lo ACY, Yam GHF, Jhanji V, Shih KC, Chan YK
Exp Eye Res 2021 Oct;211:108747. Epub 2021 Aug 24 doi: 10.1016/j.exer.2021.108747. PMID: 34450184
Pericytes reduce inflammation and collagen deposition in acute wounds.
Bodnar RJ, Yang T, Rigatti LH, Liu F, Evdokiou A, Kathju S, Satish L
Cytotherapy 2018 Aug;20(8):1046-1060. Epub 2018 Aug 6 doi: 10.1016/j.jcyt.2018.06.011. PMID: 30093323
Regulation of silicosis formation by lysophosphatidic acid and its receptors.
Cong C, Mao L, Zhang Y, Zhao Z, Xu X, Zhao J
Exp Lung Res 2014 Sep;40(7):317-26. Epub 2014 Jun 13 doi: 10.3109/01902148.2014.920438. PMID: 24926730

Diagnosis

Fibroblast Activation Protein is a GH Target: A Prospective Study of Patients with Acromegaly Before and After Treatment.
Arlien-Søborg MC, Grøndahl C, Bæk A, Dal J, Madsen M, Høgild ML, Pedersen SB, Bjerre M, Jørgensen JOL
J Clin Endocrinol Metab 2020 Jan 1;105(1) doi: 10.1210/clinem/dgz033. PMID: 31544947
Matrix metalloproteinase-1 cleavage site recognition and binding in full-length human type III collagen.
Williams KE, Olsen DR
Matrix Biol 2009 Jul;28(6):373-9. Epub 2009 Apr 24 doi: 10.1016/j.matbio.2009.04.009. PMID: 19398000
Fibroblast-like transformation and c-myc gene alteration of human hepatocytes induced by novobiocin and butyrate.
Kaneko Y, Nakayama T, Hamasaki T, Tsukamoto A, Toda G, Oka H
Biochem Biophys Res Commun 1988 Aug 30;155(1):305-10. doi: 10.1016/s0006-291x(88)81085-4. PMID: 2843181
Hyaluronate and type III procollagen peptide concentrations in bronchoalveolar lavage fluid as markers of disease activity in farmer's lung.
Bjermer L, Engström-Laurent A, Lundgren R, Rosenhall L, Hällgren R
Br Med J (Clin Res Ed) 1987 Oct 3;295(6602):803-6. doi: 10.1136/bmj.295.6602.803. PMID: 3119050Free PMC Article
The collagen substrate specificity of human neutrophil collagenase.
Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG
J Biol Chem 1987 Jul 25;262(21):10048-52. PMID: 3038863

Therapy

Novel roles of bovine milk-derived exosomes in skin antiaging.
Lu L, Bai W, Wang M, Han C, Du H, Wang N, Gao M, Li D, Dong F, Ge X
J Cosmet Dermatol 2024 Apr;23(4):1374-1385. Epub 2023 Dec 17 doi: 10.1111/jocd.16112. PMID: 38105431
Cathelicidin LL-37 Expression in Human Breast Implant Capsules.
Segreto F, Carotti S, Marangi GF, Francesconi M, Calia E, Cagli B, Cimmino A, Rossi C, Morini S, Persichetti P
Plast Reconstr Surg 2024 May 1;153(5):1066-1073. Epub 2023 May 22 doi: 10.1097/PRS.0000000000010733. PMID: 37220260
Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Compensated Cirrhosis (FALCON 2): A Randomized Phase 2b Study.
Abdelmalek MF, Sanyal AJ, Nakajima A, Neuschwander-Tetri BA, Goodman ZD, Lawitz EJ, Harrison SA, Jacobson IM, Imajo K, Gunn N, Halegoua-DeMarzio D, Akahane T, Boone B, Yamaguchi M, Chatterjee A, Tirucherai GS, Shevell DE, Du S, Charles ED, Loomba R
Clin Gastroenterol Hepatol 2024 Jan;22(1):113-123.e9. Epub 2023 Apr 23 doi: 10.1016/j.cgh.2023.04.012. PMID: 37088458
Neoadjuvant therapy alters the collagen architecture of pancreatic cancer tissue via Ephrin-A5.
Nakajima K, Ino Y, Naito C, Nara S, Shimasaki M, Ishimoto U, Iwasaki T, Doi N, Esaki M, Kishi Y, Shimada K, Hiraoka N
Br J Cancer 2022 Mar;126(4):628-639. Epub 2021 Nov 25 doi: 10.1038/s41416-021-01639-9. PMID: 34824448Free PMC Article
Liposome-encapsulated statins reduce hypertrophic scarring through topical application.
Xie P, Dolivo DM, Jia S, Cheng X, Salcido J, Galiano RD, Hong SJ, Mustoe TA
Wound Repair Regen 2020 Jul;28(4):460-469. Epub 2020 May 19 doi: 10.1111/wrr.12811. PMID: 32428986

Prognosis

Cathelicidin LL-37 Expression in Human Breast Implant Capsules.
Segreto F, Carotti S, Marangi GF, Francesconi M, Calia E, Cagli B, Cimmino A, Rossi C, Morini S, Persichetti P
Plast Reconstr Surg 2024 May 1;153(5):1066-1073. Epub 2023 May 22 doi: 10.1097/PRS.0000000000010733. PMID: 37220260
The anti-scarring role of Lycium barbarum polysaccharide on cornea epithelial-stromal injury.
Wong HL, Hung LT, Kwok SS, Bu Y, Lin Y, Shum HC, Wang H, Lo ACY, Yam GHF, Jhanji V, Shih KC, Chan YK
Exp Eye Res 2021 Oct;211:108747. Epub 2021 Aug 24 doi: 10.1016/j.exer.2021.108747. PMID: 34450184
Prognostic value of blood-based fibrosis biomarkers in patients with metastatic colorectal cancer receiving chemotherapy and bevacizumab.
Nissen NI, Kehlet S, Boisen MK, Liljefors M, Jensen C, Johansen AZ, Johansen JS, Erler JT, Karsdal M, Mortensen JH, Høye A, Willumsen N
Sci Rep 2021 Jan 13;11(1):865. doi: 10.1038/s41598-020-79608-0. PMID: 33441622Free PMC Article
Pathogenesis investigation of miR-199-5p in oral submucous fibrosis based on bioinformatics analysis.
Yuan Y, Li N, Zeng L, Shen Z, Jiang C
Oral Dis 2019 Mar;25(2):456-465. Epub 2018 Dec 19 doi: 10.1111/odi.13008. PMID: 30485610
Hyaluronate and type III procollagen peptide concentrations in bronchoalveolar lavage fluid as markers of disease activity in farmer's lung.
Bjermer L, Engström-Laurent A, Lundgren R, Rosenhall L, Hällgren R
Br Med J (Clin Res Ed) 1987 Oct 3;295(6602):803-6. doi: 10.1136/bmj.295.6602.803. PMID: 3119050Free PMC Article

Clinical prediction guides

Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
Kim SH, Oh JM, Roh H, Lee KW, Lee JH, Lee WJ
Tissue Eng Regen Med 2024 Oct;21(7):1079-1092. Epub 2024 Aug 6 doi: 10.1007/s13770-024-00664-y. PMID: 39105875Free PMC Article
Recombinant Human Collagen Type III Improves Hypertrophic Scarring by Regulating the Ratio of Type I/III Collagen.
Lin-Hui L, Yuan-Yuan Z, Ming-Yu L, Xu-Dong H, Yin-Jia D, Yue Z, Yang-Hong-Hong F, Ai-Fen C, Xu-Dong Z, Zheng-Li C, Jian J
J Burn Care Res 2024 Sep 6;45(5):1269-1273. doi: 10.1093/jbcr/irae040. PMID: 38477626
Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Compensated Cirrhosis (FALCON 2): A Randomized Phase 2b Study.
Abdelmalek MF, Sanyal AJ, Nakajima A, Neuschwander-Tetri BA, Goodman ZD, Lawitz EJ, Harrison SA, Jacobson IM, Imajo K, Gunn N, Halegoua-DeMarzio D, Akahane T, Boone B, Yamaguchi M, Chatterjee A, Tirucherai GS, Shevell DE, Du S, Charles ED, Loomba R
Clin Gastroenterol Hepatol 2024 Jan;22(1):113-123.e9. Epub 2023 Apr 23 doi: 10.1016/j.cgh.2023.04.012. PMID: 37088458
Calpastatin-Mediated Inhibition of Calpain Ameliorates Skin Scar Formation after Burn Injury.
Seo CH, Cui HS, Kim JB
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115771. PMID: 34071277Free PMC Article
Decorin-expressing adenovirus decreases collagen synthesis and upregulates MMP expression in keloid fibroblasts and keloid spheroids.
Lee WJ, Ahn HM, Roh H, Na Y, Choi IK, Lee JH, Kim YO, Lew DH, Yun CO
Exp Dermatol 2015 Aug;24(8):591-7. Epub 2015 May 8 doi: 10.1111/exd.12719. PMID: 25865370

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