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Elevated CSF dopamine concentration

MedGen UID:
1841526
•Concept ID:
C5826352
•
Finding
HPO: HP:0012655

Definition

Increased concentration of dopamine in the cerebrospinal fluid (CSF). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated CSF dopamine concentration

Professional guidelines

PubMed

Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders.
Erhardt S, Olsson SK, Engberg G
CNS Drugs 2009;23(2):91-101. doi: 10.2165/00023210-200923020-00001. PMID: 19173370
A risk-benefit assessment of sulpiride in the treatment of schizophrenia.
Mauri MC, Bravin S, Bitetto A, Rudelli R, Invernizzi G
Drug Saf 1996 May;14(5):288-98. doi: 10.2165/00002018-199614050-00003. PMID: 8800626

Recent clinical studies

Etiology

A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson's disease.
Serrano-Marín J, Marin S, Bernal-Casas D, Lillo A, González-Subías M, Navarro G, Cascante M, Sánchez-Navés J, Franco R
Fluids Barriers CNS 2023 Dec 4;20(1):90. doi: 10.1186/s12987-023-00494-5. PMID: 38049870Free PMC Article
Simultaneous assay of urine sepiapterin and creatinine in patients with sepiapterin reductase deficiency.
Hyodo Y, Akiyama T, Fukuyama T, Mimaki M, Watanabe K, Kumagai T, Kobayashi K
Clin Chim Acta 2022 Sep 1;534:167-172. Epub 2022 Aug 1 doi: 10.1016/j.cca.2022.07.016. PMID: 35926683
Targeting urate to reduce oxidative stress in Parkinson disease.
Crotty GF, Ascherio A, Schwarzschild MA
Exp Neurol 2017 Dec;298(Pt B):210-224. Epub 2017 Jun 13 doi: 10.1016/j.expneurol.2017.06.017. PMID: 28622913Free PMC Article
CSF neurotransmitter metabolites and short-term outcome of patients in coma after head injury.
Markianos M, Seretis A, Kotsou S, Baltas I, Sacharogiannis H
Acta Neurol Scand 1992 Aug;86(2):190-3. doi: 10.1111/j.1600-0404.1992.tb05064.x. PMID: 1384260
Elevated cerebrospinal fluid noradrenaline in tardive dyskinesia.
Jeste DV, Doongaji DR, Linnoila M
Br J Psychiatry 1984 Feb;144:177-80. doi: 10.1192/bjp.144.2.177. PMID: 6200172

Diagnosis

A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson's disease.
Serrano-Marín J, Marin S, Bernal-Casas D, Lillo A, González-Subías M, Navarro G, Cascante M, Sánchez-Navés J, Franco R
Fluids Barriers CNS 2023 Dec 4;20(1):90. doi: 10.1186/s12987-023-00494-5. PMID: 38049870Free PMC Article
CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance.
Orhan F, Goiny M, Becklén M, Mathé L, Piehl F, Schwieler L, Fatouros-Bergman H, Farde L, Cervenka S, Sellgren CM, Engberg G, Erhardt S
Schizophr Res 2023 Jul;257:34-40. Epub 2023 Jun 2 doi: 10.1016/j.schres.2023.05.012. PMID: 37271040
Simultaneous assay of urine sepiapterin and creatinine in patients with sepiapterin reductase deficiency.
Hyodo Y, Akiyama T, Fukuyama T, Mimaki M, Watanabe K, Kumagai T, Kobayashi K
Clin Chim Acta 2022 Sep 1;534:167-172. Epub 2022 Aug 1 doi: 10.1016/j.cca.2022.07.016. PMID: 35926683
Targeting urate to reduce oxidative stress in Parkinson disease.
Crotty GF, Ascherio A, Schwarzschild MA
Exp Neurol 2017 Dec;298(Pt B):210-224. Epub 2017 Jun 13 doi: 10.1016/j.expneurol.2017.06.017. PMID: 28622913Free PMC Article
CSF neurotransmitter metabolites and short-term outcome of patients in coma after head injury.
Markianos M, Seretis A, Kotsou S, Baltas I, Sacharogiannis H
Acta Neurol Scand 1992 Aug;86(2):190-3. doi: 10.1111/j.1600-0404.1992.tb05064.x. PMID: 1384260

Therapy

Effects of raclopride treatment on plasma and CSF HVA: relationships with clinical improvement in male schizophrenics.
Csernansky JG, Newcomer JW, Jackson K, Lombrozo L, Faull KF, Zipursky R, Pfefferbaum A, Faustman WO
Psychopharmacology (Berl) 1994 Nov;116(3):291-6. doi: 10.1007/BF02245331. PMID: 7534423
Elevated cerebrospinal fluid noradrenaline in tardive dyskinesia.
Jeste DV, Doongaji DR, Linnoila M
Br J Psychiatry 1984 Feb;144:177-80. doi: 10.1192/bjp.144.2.177. PMID: 6200172
The effect of pimozide on CSF norepinephrine in schizophrenia.
Sternberg DE, van Kammen DP, Lake CR, Ballenger JC, Marder SR, Bunney WE Jr
Am J Psychiatry 1981 Aug;138(8):1045-50. doi: 10.1176/ajp.138.8.1045. PMID: 7258379
Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion.
Davis KL, Faull KF, Hollister LE, Barchas JD, Berger PA
Psychopharmacology (Berl) 1981;72(2):155-60. doi: 10.1007/BF00431649. PMID: 6782605
CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia.
Stoerner JW, Butler IJ, Morriss FH Jr, Howell RR, Seifert WE Jr, Caprioli RM, Adcock EW 3rd, Denson SE
Am J Dis Child 1980 May;134(5):492-4. doi: 10.1001/archpedi.1980.02130170042014. PMID: 6155067

Prognosis

Targeting urate to reduce oxidative stress in Parkinson disease.
Crotty GF, Ascherio A, Schwarzschild MA
Exp Neurol 2017 Dec;298(Pt B):210-224. Epub 2017 Jun 13 doi: 10.1016/j.expneurol.2017.06.017. PMID: 28622913Free PMC Article
Aromatic L-amino acid decarboxylase deficiency: clinical features, drug therapy and follow-up.
Manegold C, Hoffmann GF, Degen I, Ikonomidou H, Knust A, Laass MW, Pritsch M, Wilichowski E, Hörster F
J Inherit Metab Dis 2009 Jun;32(3):371-80. Epub 2009 Jan 28 doi: 10.1007/s10545-009-1076-1. PMID: 19172410
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder.
Sullivan GM, Oquendo MA, Huang YY, Mann JJ
Int J Neuropsychopharmacol 2006 Oct;9(5):547-56. Epub 2005 Nov 1 doi: 10.1017/S1461145705006231. PMID: 16259647
Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia.
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT
Am J Psychiatry 1998 Sep;155(9):1207-13. doi: 10.1176/ajp.155.9.1207. PMID: 9734544
CSF neurotransmitter metabolites and short-term outcome of patients in coma after head injury.
Markianos M, Seretis A, Kotsou S, Baltas I, Sacharogiannis H
Acta Neurol Scand 1992 Aug;86(2):190-3. doi: 10.1111/j.1600-0404.1992.tb05064.x. PMID: 1384260

Clinical prediction guides

CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance.
Orhan F, Goiny M, Becklén M, Mathé L, Piehl F, Schwieler L, Fatouros-Bergman H, Farde L, Cervenka S, Sellgren CM, Engberg G, Erhardt S
Schizophr Res 2023 Jul;257:34-40. Epub 2023 Jun 2 doi: 10.1016/j.schres.2023.05.012. PMID: 37271040
Tumor metabolism and neurocognition in CNS lymphoma.
Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL
Neuro Oncol 2021 Oct 1;23(10):1668-1679. doi: 10.1093/neuonc/noab045. PMID: 33625503Free PMC Article
Targeting urate to reduce oxidative stress in Parkinson disease.
Crotty GF, Ascherio A, Schwarzschild MA
Exp Neurol 2017 Dec;298(Pt B):210-224. Epub 2017 Jun 13 doi: 10.1016/j.expneurol.2017.06.017. PMID: 28622913Free PMC Article
CSF neurotransmitter metabolites and short-term outcome of patients in coma after head injury.
Markianos M, Seretis A, Kotsou S, Baltas I, Sacharogiannis H
Acta Neurol Scand 1992 Aug;86(2):190-3. doi: 10.1111/j.1600-0404.1992.tb05064.x. PMID: 1384260
CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia.
Stoerner JW, Butler IJ, Morriss FH Jr, Howell RR, Seifert WE Jr, Caprioli RM, Adcock EW 3rd, Denson SE
Am J Dis Child 1980 May;134(5):492-4. doi: 10.1001/archpedi.1980.02130170042014. PMID: 6155067

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