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Combined low LDL and fibrinogen(CLDLFIB)

MedGen UID:
1841120
•Concept ID:
C5830484
•
Finding
Synonym: CLDLFIB
 
Gene (location): B4GALT1 (9p21.1)
 
Monarch Initiative: MONDO:0957260
OMIM®: 620364

Clinical features

From HPO
Hypofibrinogenemia
MedGen UID:
107511
•Concept ID:
C0553681
•
Disease or Syndrome
Decreased concentration of fibrinogen in the blood.
See: Feature record | Search on this feature
Elevated circulating aspartate aminotransferase concentration
MedGen UID:
57497
•Concept ID:
C0151904
•
Finding
The concentration of aspartate aminotransferase (AST) in the blood circulation is above the upper limit of normal.
See: Feature record | Search on this feature
Decreased LDL cholesterol concentration
MedGen UID:
776554
•Concept ID:
C0853085
•
Finding
An decreased concentration of low-density lipoprotein cholesterol in the blood.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Evaluation of the treatment volume and removal rate of Rheocarna: A novel adsorption-type blood purification device for patients with chronic limb-threatening ischemia.
Ohkubo A, Sakurasawa T, Hoshikawa Y, Usui M, Hoshi M, Shiga T, Deushi M, Komori S, Itagaki A, Yamamoto H, Seshima H, Kurashima N, Iimori S, Naito S
Ther Apher Dial 2023 Dec;27(6):1017-1022. Epub 2023 Aug 17 doi: 10.1111/1744-9987.14050. PMID: 37589198
Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options.
Serban MC, Banach M, Mikhailidis DP
Expert Opin Pharmacother 2016;17(3):369-80. Epub 2015 Nov 30 doi: 10.1517/14656566.2016.1118055. PMID: 26559810
Prevention and treatment of the metabolic syndrome.
Daskalopoulou SS, Mikhailidis DP, Elisaf M
Angiology 2004 Nov-Dec;55(6):589-612. doi: 10.1177/00033197040550i601. PMID: 15547646

Recent clinical studies

Etiology

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial.
Boshagh K, Khorvash F, Sahebkar A, Majeed M, Bahreini N, Askari G, Bagherniya M
Nutr J 2023 Dec 11;22(1):69. doi: 10.1186/s12937-023-00905-1. PMID: 38082237Free PMC Article
Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor.
Tenenbaum A, Klempfner R, Fisman EZ
Cardiovasc Diabetol 2014 Dec 4;13:159. doi: 10.1186/s12933-014-0159-y. PMID: 25471221Free PMC Article
Fenofibrate: a review of its use in dyslipidaemia.
McKeage K, Keating GM
Drugs 2011 Oct 1;71(14):1917-46. doi: 10.2165/11208090-000000000-00000. PMID: 21942979
Low-density lipoprotein apheresis: an overview.
Bambauer R, Schiel R, Latza R
Ther Apher Dial 2003 Aug;7(4):382-90. doi: 10.1046/j.1526-0968.2003.00070.x. PMID: 12887719
Bezafibrate. An update of its pharmacology and use in the management of dyslipidaemia.
Goa KL, Barradell LB, Plosker GL
Drugs 1996 Nov;52(5):725-53. doi: 10.2165/00003495-199652050-00008. PMID: 9118820

Diagnosis

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial.
Boshagh K, Khorvash F, Sahebkar A, Majeed M, Bahreini N, Askari G, Bagherniya M
Nutr J 2023 Dec 11;22(1):69. doi: 10.1186/s12937-023-00905-1. PMID: 38082237Free PMC Article
Effects of Serum LDL-C, CysC, and D-D in Patients with Coronary Atherosclerotic Heart Disease.
Shen C, Wang J, Tu S
Comput Intell Neurosci 2022;2022:5771960. Epub 2022 Jun 28 doi: 10.1155/2022/5771960. PMID: 35800677Free PMC Article
Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease.
Markelić I, Hlapčić I, Rogić D, Rako I, Samaržija M, Popović-Grle S, Rumora L, Vukić Dugac A
Nutr Metab Cardiovasc Dis 2021 Jan 4;31(1):153-161. Epub 2020 Aug 5 doi: 10.1016/j.numecd.2020.07.039. PMID: 32981798
Obesity, weight loss and conditional cardiovascular risk factors.
Tzotzas T, Evangelou P, Kiortsis DN
Obes Rev 2011 May;12(5):e282-9. Epub 2010 Nov 3 doi: 10.1111/j.1467-789X.2010.00807.x. PMID: 21054756
Low-density lipoprotein apheresis: an overview.
Bambauer R, Schiel R, Latza R
Ther Apher Dial 2003 Aug;7(4):382-90. doi: 10.1046/j.1526-0968.2003.00070.x. PMID: 12887719

Therapy

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial.
Boshagh K, Khorvash F, Sahebkar A, Majeed M, Bahreini N, Askari G, Bagherniya M
Nutr J 2023 Dec 11;22(1):69. doi: 10.1186/s12937-023-00905-1. PMID: 38082237Free PMC Article
Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor.
Tenenbaum A, Klempfner R, Fisman EZ
Cardiovasc Diabetol 2014 Dec 4;13:159. doi: 10.1186/s12933-014-0159-y. PMID: 25471221Free PMC Article
Fenofibrate: a review of its use in dyslipidaemia.
McKeage K, Keating GM
Drugs 2011 Oct 1;71(14):1917-46. doi: 10.2165/11208090-000000000-00000. PMID: 21942979
Low-density lipoprotein apheresis: an overview.
Bambauer R, Schiel R, Latza R
Ther Apher Dial 2003 Aug;7(4):382-90. doi: 10.1046/j.1526-0968.2003.00070.x. PMID: 12887719
Omega-3 fatty acids in health and disease and in growth and development.
Simopoulos AP
Am J Clin Nutr 1991 Sep;54(3):438-63. doi: 10.1093/ajcn/54.3.438. PMID: 1908631

Prognosis

Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease.
Markelić I, Hlapčić I, Rogić D, Rako I, Samaržija M, Popović-Grle S, Rumora L, Vukić Dugac A
Nutr Metab Cardiovasc Dis 2021 Jan 4;31(1):153-161. Epub 2020 Aug 5 doi: 10.1016/j.numecd.2020.07.039. PMID: 32981798
Low-density lipoprotein apheresis: an overview.
Bambauer R, Schiel R, Latza R
Ther Apher Dial 2003 Aug;7(4):382-90. doi: 10.1046/j.1526-0968.2003.00070.x. PMID: 12887719
Current topics on low-density lipoprotein apheresis.
Bambauer R, Schiel R, Latza R
Ther Apher 2001 Aug;5(4):293-300. doi: 10.1046/j.1526-0968.2001.00359.x. PMID: 11724515
Bezafibrate. An update of its pharmacology and use in the management of dyslipidaemia.
Goa KL, Barradell LB, Plosker GL
Drugs 1996 Nov;52(5):725-53. doi: 10.2165/00003495-199652050-00008. PMID: 9118820
Oral contraceptives and coronary heart disease.
Wynn V
J Reprod Med 1991 Mar;36(3 Suppl):219-25. PMID: 2046075

Clinical prediction guides

The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial.
Boshagh K, Khorvash F, Sahebkar A, Majeed M, Bahreini N, Askari G, Bagherniya M
Nutr J 2023 Dec 11;22(1):69. doi: 10.1186/s12937-023-00905-1. PMID: 38082237Free PMC Article
Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia.
Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD, Tousoulis D
J Clin Lipidol 2018 Jan-Feb;12(1):33-43. Epub 2017 Nov 2 doi: 10.1016/j.jacl.2017.10.019. PMID: 29174439
Combined treatment with low-dose pravastatin and fish oil in post-renal transplantation dislipidemia.
Grekas D, Kassimatis E, Makedou A, Bacharaki D, Bamichas G, Tourkantonis A
Nephron 2001 Aug;88(4):329-33. doi: 10.1159/000046016. PMID: 11474227
Bezafibrate. An update of its pharmacology and use in the management of dyslipidaemia.
Goa KL, Barradell LB, Plosker GL
Drugs 1996 Nov;52(5):725-53. doi: 10.2165/00003495-199652050-00008. PMID: 9118820
Oral contraceptives and coronary heart disease.
Wynn V
J Reprod Med 1991 Mar;36(3 Suppl):219-25. PMID: 2046075

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