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Triple-positive breast carcinoma

MedGen UID:
1825949
•Concept ID:
C5243562
•
Neoplastic Process
Synonyms: hormone receptor positive her2 positive breast cancer; HR-positive HER2 positive breast cancer; triple positive breast cancer; triple-positive breast carcinoma
 
Monarch Initiative: MONDO:0700078

Definition

A breast carcinoma which is positive for expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). [from MONDO]

Professional guidelines

PubMed

Optimizing treatment for HER2-positive HR-positive breast cancer.
Debien V, de Azambuja E, Piccart-Gebhart M
Cancer Treat Rev 2023 Apr;115:102529. Epub 2023 Feb 28 doi: 10.1016/j.ctrv.2023.102529. PMID: 36921556
Current trends in the treatment of HR+/HER2+ breast cancer.
Kay C, Martínez-Pérez C, Meehan J, Gray M, Webber V, Dixon JM, Turnbull AK
Future Oncol 2021 May;17(13):1665-1681. Epub 2021 Mar 17 doi: 10.2217/fon-2020-0504. PMID: 33726508
HER2-positive advanced breast cancer treatment in 2020.
Cesca MG, Vian L, Cristóvão-Ferreira S, Pondé N, de Azambuja E
Cancer Treat Rev 2020 Aug;88:102033. Epub 2020 May 22 doi: 10.1016/j.ctrv.2020.102033. PMID: 32534233

Recent clinical studies

Etiology

Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article

Diagnosis

A Novel HER2 Protein Identification Methodology in Breast Cancer Cells Using Raman Spectroscopy and Raman Imaging: An Analytical Validation Study.
Abramczyk H, Surmacki JM, Kopeć M
J Med Chem 2024 Oct 10;67(19):17629-17639. Epub 2024 Sep 21 doi: 10.1021/acs.jmedchem.4c01591. PMID: 39305290Free PMC Article
Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway.
Dukhanina EA, Portseva TN, Dukhanin AS, Georgieva SG
Cell Adh Migr 2022 Dec;16(1):65-71. doi: 10.1080/19336918.2022.2072554. PMID: 35546077Free PMC Article

Therapy

Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article

Prognosis

Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article
Syndecan-1 is a potential biomarker for triple-positive breast carcinomas in Asian women with correlation to survival.
Lim GH, Tan PH, Jara-Lazaro AR, Thike AA, Sim WC, Yap VB, Yip GW
Singapore Med J 2014 Sep;55(9):468-72. doi: 10.11622/smedj.2014115. PMID: 25273930Free PMC Article

Clinical prediction guides

Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article
Syndecan-1 is a potential biomarker for triple-positive breast carcinomas in Asian women with correlation to survival.
Lim GH, Tan PH, Jara-Lazaro AR, Thike AA, Sim WC, Yap VB, Yip GW
Singapore Med J 2014 Sep;55(9):468-72. doi: 10.11622/smedj.2014115. PMID: 25273930Free PMC Article

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