From HPO
Chest pain- MedGen UID:
- 2992
- •Concept ID:
- C0008031
- •
- Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
Aortic regurgitation- MedGen UID:
- 8153
- •Concept ID:
- C0003504
- •
- Disease or Syndrome
An insufficiency of the aortic valve, leading to regurgitation (backward flow) of blood from the aorta into the left ventricle.
Heart murmur- MedGen UID:
- 9171
- •Concept ID:
- C0018808
- •
- Finding
An extra or unusual sound heard during a heartbeat caused vibrations resulting from the flow of blood through the heart.
Palpitations- MedGen UID:
- 14579
- •Concept ID:
- C0030252
- •
- Finding
A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.
Pulmonary valve insufficiency- MedGen UID:
- 11031
- •Concept ID:
- C0034088
- •
- Pathologic Function
The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole.
Tricuspid regurgitation- MedGen UID:
- 11911
- •Concept ID:
- C0040961
- •
- Disease or Syndrome
Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium.
Bicuspid aortic valve- MedGen UID:
- 57436
- •Concept ID:
- C0149630
- •
- Congenital Abnormality
Aortic valve disease-2 (AOVD2) is characterized by bicuspid aortic valve (BAV) and dilation of the ascending aorta. Calcification of the valve and the aorta has been observed, and some patients exhibit coarctation of the aorta (Tan et al., 2012; Luyckx et al., 2019; Park et al., 2019).
For a general phenotypic description and a discussion of genetic heterogeneity of aortic valve disease, see AOVD1 (109730).
Systolic heart murmur- MedGen UID:
- 115909
- •Concept ID:
- C0232257
- •
- Finding
A heart murmur limited to systole, i.e., between the first and second heart sounds S1 and S2.
Subvalvular aortic stenosis- MedGen UID:
- 90950
- •Concept ID:
- C0340375
- •
- Disease or Syndrome
A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve.
Pulmonary artery dilatation- MedGen UID:
- 140900
- •Concept ID:
- C0428851
- •
- Disease or Syndrome
An abnormal widening of the diameter of the pulmonary artery.
Ascending tubular aorta aneurysm- MedGen UID:
- 163631
- •Concept ID:
- C0856747
- •
- Anatomical Abnormality
An abnormal localized widening (dilatation) of the tubular part of the ascending aorta.
Left ventricular diastolic dysfunction- MedGen UID:
- 696562
- •Concept ID:
- C1273070
- •
- Disease or Syndrome
Abnormal function of the left ventricule during left ventricular relaxation and filling.
Dysplastic aortic valve- MedGen UID:
- 355656
- •Concept ID:
- C1866207
- •
- Finding
A congenital malformation of the aortic valve characterized by leaflet deformation.
Pulmonic stenosis- MedGen UID:
- 408291
- •Concept ID:
- C1956257
- •
- Disease or Syndrome
A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis), below the pulmonary valve (infundibular stenosis), or above the pulmonary valve (supravalvar stenosis).
Increased left ventricular end-diastolic volume- MedGen UID:
- 1660169
- •Concept ID:
- C4748648
- •
- Finding
Abnormally high volume of blood in the left ventricle at the end of diastole (just before systole).
Central cyanosis- MedGen UID:
- 636837
- •Concept ID:
- C0521800
- •
- Finding
Generalized bluish discoloration of the body and the visible mucous membranes, which occurs due to inadequate oxygenation secondary to conditions that lead to an increase in deoxygenated hemoglobin or presence of abnormal hemoglobin.
- Abnormality of the cardiovascular system
- Abnormality of the integument
- Constitutional symptom