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Secondary hypertrophic osteoarthropathy

MedGen UID:
18211
•Concept ID:
C0029412
•
Disease or Syndrome
Synonyms: Disease, Marie-Bamberger; Hypertrophic Osteoarthropathies, Secondary; Hypertrophic Osteoarthropathy, Secondary; Marie Bamberger Disease; Marie-Bamberger Disease; Osteoarthropathies, Secondary Hypertrophic; Osteoarthropathy, Secondary Hypertrophic; Secondary Hypertrophic Osteoarthropathies; Secondary Hypertrophic Osteoarthropathy
SNOMED CT: Hypertrophic pulmonary osteoarthropathy (203357004); Pachydermoperiostitis acquired (203357004); Marie Bamberger disease (203357004); HPOA - Hypertrophic pulmonary osteoarthropathy (203357004)
 
Monarch Initiative: MONDO:0006965

Definition

Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary hypertrophic osteoarthropathy

Professional guidelines

PubMed

Secondary hypertrophic osteoarthropathy: new insights on pathogenesis and management.
Nahar I, Al-Shemmeri M, Hussain M
Gulf J Oncolog 2007 Jan;1(1):71-6. PMID: 20084716

Recent clinical studies

Etiology

Epidemiology of Digital Clubbing and Hypertrophic Osteoarthropathy: A Systematic Review and Meta-analysis.
Essouma M, Nkeck JR, Agbor VN, Noubiap JJ
J Clin Rheumatol 2022 Mar 1;28(2):104-110. doi: 10.1097/RHU.0000000000001830. PMID: 35067513
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors.
Meyer HJ, Leifels L, Bach AG, Surov A
Medicine (Baltimore) 2017 Sep;96(36):e7985. doi: 10.1097/MD.0000000000007985. PMID: 28885355Free PMC Article
Cutaneous manifestations of lung cancer.
Owen CE
Semin Oncol 2016 Jun;43(3):366-9. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.025. PMID: 27178690
Extrathyroidal manifestations of Graves' disease: a 2014 update.
Bartalena L, Fatourechi V
J Endocrinol Invest 2014 Aug;37(8):691-700. Epub 2014 Jun 10 doi: 10.1007/s40618-014-0097-2. PMID: 24913238
Graphite pneumoconiosis.
Ranasinha KW, Uragoda CG
Br J Ind Med 1972 Apr;29(2):178-83. doi: 10.1136/oem.29.2.178. PMID: 5021997Free PMC Article

Diagnosis

Secondary Hypertrophic Osteoarthropathy.
Lucas Rocha M, Silvestre-Teixeira V
N Engl J Med 2024 Apr 4;390(13):1218. doi: 10.1056/NEJMicm2309119. PMID: 38598576
Hypertrophic osteoarthropathy.
Martínez-Lavín M
Best Pract Res Clin Rheumatol 2020 Jun;34(3):101507. Epub 2020 Apr 11 doi: 10.1016/j.berh.2020.101507. PMID: 32291203
Touraine-Solente-Gole syndrome.
Doshi D
Orbit 2018 Apr;37(2):97-101. Epub 2017 Oct 17 doi: 10.1080/01676830.2017.1383459. PMID: 29040027
Hypertrophic Osteoarthropathy.
Carlson S, Rauchenstein J
J Am Osteopath Assoc 2015 Dec;115(12):745. doi: 10.7556/jaoa.2015.153. PMID: 26618821
Hypertrophic osteoarthropathy.
Martínez-Lavín M
Curr Opin Rheumatol 1997 Jan;9(1):83-6. PMID: 9110140

Therapy

Epidemiology of Digital Clubbing and Hypertrophic Osteoarthropathy: A Systematic Review and Meta-analysis.
Essouma M, Nkeck JR, Agbor VN, Noubiap JJ
J Clin Rheumatol 2022 Mar 1;28(2):104-110. doi: 10.1097/RHU.0000000000001830. PMID: 35067513
Primary hypertrophic osteoarthropathy: an update.
Zhang Z, Zhang C, Zhang Z
Front Med 2013 Mar;7(1):60-4. Epub 2013 Jan 23 doi: 10.1007/s11684-013-0246-6. PMID: 23345113
Touraine-Solente-Gole' syndrome.
Gupta M, Lehl SS, Singh R, Sachdev A
BMJ Case Rep 2011 Sep 28;2011 doi: 10.1136/bcr.08.2011.4605. PMID: 22679327Free PMC Article
Review of current therapies for secondary hypertrophic pulmonary osteoarthropathy.
Nguyen S, Hojjati M
Clin Rheumatol 2011 Jan;30(1):7-13. Epub 2010 Oct 9 doi: 10.1007/s10067-010-1563-7. PMID: 20936419
Complications of mediastinal neural tumours.
Parish C
Thorax 1971 Jul;26(4):392-5. doi: 10.1136/thx.26.4.392. PMID: 4327710Free PMC Article

Prognosis

Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.
Bozzao F, Bernardi S, Dore F, Zandonà L, Fischetti F
BMC Musculoskelet Disord 2018 May 14;19(1):145. doi: 10.1186/s12891-018-2068-9. PMID: 29759083Free PMC Article
Clubbing and hypertrophic osteoarthropathy: insights in diagnosis, pathophysiology, and clinical significance.
Callemeyn J, Van Haecke P, Peetermans WE, Blockmans D
Acta Clin Belg 2016 Jun;71(3):123-30. Epub 2016 Apr 22 doi: 10.1080/17843286.2016.1152672. PMID: 27104368
Clubbing: an update on diagnosis, differential diagnosis, pathophysiology, and clinical relevance.
Spicknall KE, Zirwas MJ, English JC 3rd
J Am Acad Dermatol 2005 Jun;52(6):1020-8. doi: 10.1016/j.jaad.2005.01.006. PMID: 15928621
Epithelioid haemangioendothelioma.
Ledson MJ, Convery R, Carty A, Evans CC
Thorax 1999 Jun;54(6):560-1. doi: 10.1136/thx.54.6.560. PMID: 10335015Free PMC Article
Diagnosis and treatment of cystic fibrosis. An update.
Davis PB, di Sant'Agnese PA
Chest 1984 Jun;85(6):802-9. doi: 10.1016/s0012-3692(16)62421-2. PMID: 6373170

Clinical prediction guides

Massive periostosis in a child from Neolithic Gebel es-Silsileh, Egypt.
Gresky J, Schultz M
Anthropol Anz 2023 Sep 28;80(4):501-516. doi: 10.1127/anthranz/2022/1613. PMID: 36278913
Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany.
Flohr S, Jasch I, Langer A, Riesenberg M, Hahn J, Wisotzki A, Kierdorf H, Kierdorf U, Wahl J
Int J Paleopathol 2018 Mar;20:72-79. Epub 2017 Nov 21 doi: 10.1016/j.ijpp.2017.10.013. PMID: 29496219
Pseudoclubbing: is it different from clubbing?
Santiago MB, Lima I, Feitosa AC, Braz Ade S, Miranda LG
Semin Arthritis Rheum 2009 Jun;38(6):452-7. Epub 2008 Apr 18 doi: 10.1016/j.semarthrit.2008.01.018. PMID: 18378280
Clubbing and koilonychia.
Stone OJ
Dermatol Clin 1985 Jul;3(3):485-90. PMID: 3830509
Diagnosis and treatment of cystic fibrosis. An update.
Davis PB, di Sant'Agnese PA
Chest 1984 Jun;85(6):802-9. doi: 10.1016/s0012-3692(16)62421-2. PMID: 6373170

Recent systematic reviews

Role of bisphosphonates in hypertrophic osteoarthropathy: a systematic review.
Palui R, Sridharan K, Sahoo J, Suryadevara V, Kamalanathan S, Naik D, Halanaik D, Durgia H, Raj H
Endocrine 2024 Aug;85(2):883-893. Epub 2024 Apr 2 doi: 10.1007/s12020-024-03804-5. PMID: 38564085
Epidemiology of Digital Clubbing and Hypertrophic Osteoarthropathy: A Systematic Review and Meta-analysis.
Essouma M, Nkeck JR, Agbor VN, Noubiap JJ
J Clin Rheumatol 2022 Mar 1;28(2):104-110. doi: 10.1097/RHU.0000000000001830. PMID: 35067513
The rational clinical examination. Does this patient have clubbing?
Myers KA, Farquhar DR
JAMA 2001 Jul 18;286(3):341-7. doi: 10.1001/jama.286.3.341. PMID: 11466101

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