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Abnormal CSF homovanillic acid concentration

MedGen UID:
1814353
•Concept ID:
C5676788
•
Finding
HPO: HP:0034200

Definition

Any deviation from the normal concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine. [from HPO]

Professional guidelines

PubMed

The concentrations of GABA, 5-HIAA and HVA in the cerebrospinal fluid of children with infantile spasms and the effects of ACTH treatment.
Airaksinen E, Tuomisto L, Riikonen R
Brain Dev 1992 Nov;14(6):386-90. doi: 10.1016/s0387-7604(12)80345-7. PMID: 1283505

Recent clinical studies

Etiology

Reduced homovanillic acid, SDF-1α and SCGF-β levels in cerebrospinal fluid are related to depressive states in systemic lupus erythematosus.
Fujita Y, Iwata S, Hidese S, Ishiwata S, Ide S, Tanaka H, Sonomoto K, Miyazaki Y, Nakayamada S, Ikenouchi A, Hattori K, Kunugi H, Yoshimura R, Tanaka Y
Rheumatology (Oxford) 2023 Oct 3;62(10):3490-3500. doi: 10.1093/rheumatology/kead091. PMID: 36852847
Cerebrospinal Fluid Concentrations of Neurotransmitters in a Greek Pediatric Reference Population.
Vilanakis E, Papakonstantinou E, Paramera E, Argyri I, Drakou E, Kokkinou E, Zouvelou V, Outsika C, Pons R
Neuropediatrics 2023 Apr;54(2):126-133. Epub 2022 Nov 28 doi: 10.1055/a-1988-2412. PMID: 36442788
Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia.
Assmann B, Köhler M, Hoffmann GF, Heales S, Surtees R
Pediatr Res 2002 Jul;52(1):91-4. doi: 10.1203/00006450-200207000-00017. PMID: 12084853
Cerebrospinal fluid monoamines in Prader-Willi syndrome.
Akefeldt A, Ekman R, Gillberg C, Månsson JE
Biol Psychiatry 1998 Dec 15;44(12):1321-8. doi: 10.1016/s0006-3223(97)00519-2. PMID: 9861475
Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa.
Kaye WH, Greeno CG, Moss H, Fernstrom J, Fernstrom M, Lilenfeld LR, Weltzin TE, Mann JJ
Arch Gen Psychiatry 1998 Oct;55(10):927-35. doi: 10.1001/archpsyc.55.10.927. PMID: 9783564

Diagnosis

Reduced homovanillic acid, SDF-1α and SCGF-β levels in cerebrospinal fluid are related to depressive states in systemic lupus erythematosus.
Fujita Y, Iwata S, Hidese S, Ishiwata S, Ide S, Tanaka H, Sonomoto K, Miyazaki Y, Nakayamada S, Ikenouchi A, Hattori K, Kunugi H, Yoshimura R, Tanaka Y
Rheumatology (Oxford) 2023 Oct 3;62(10):3490-3500. doi: 10.1093/rheumatology/kead091. PMID: 36852847
Cerebrospinal Fluid Concentrations of Neurotransmitters in a Greek Pediatric Reference Population.
Vilanakis E, Papakonstantinou E, Paramera E, Argyri I, Drakou E, Kokkinou E, Zouvelou V, Outsika C, Pons R
Neuropediatrics 2023 Apr;54(2):126-133. Epub 2022 Nov 28 doi: 10.1055/a-1988-2412. PMID: 36442788
Mitochondrial diseases mimicking neurotransmitter defects.
Garcia-Cazorla A, Duarte S, Serrano M, Nascimento A, Ormazabal A, Carrilho I, Briones P, Montoya J, Garesse R, Sala-Castellvi P, Pineda M, Artuch R
Mitochondrion 2008 Jun;8(3):273-8. Epub 2008 May 21 doi: 10.1016/j.mito.2008.05.001. PMID: 18558519
Cerebrospinal fluid monoamines in Prader-Willi syndrome.
Akefeldt A, Ekman R, Gillberg C, Månsson JE
Biol Psychiatry 1998 Dec 15;44(12):1321-8. doi: 10.1016/s0006-3223(97)00519-2. PMID: 9861475
CSF and urine biogenic amine metabolites in Rett syndrome.
Lekman A, Witt-Engerström I, Holmberg B, Percy A, Svennerholm L, Hagberg B
Clin Genet 1990 Mar;37(3):173-8. doi: 10.1111/j.1399-0004.1990.tb03499.x. PMID: 1691058

Therapy

Mitochondrial diseases mimicking neurotransmitter defects.
Garcia-Cazorla A, Duarte S, Serrano M, Nascimento A, Ormazabal A, Carrilho I, Briones P, Montoya J, Garesse R, Sala-Castellvi P, Pineda M, Artuch R
Mitochondrion 2008 Jun;8(3):273-8. Epub 2008 May 21 doi: 10.1016/j.mito.2008.05.001. PMID: 18558519
Decreased homovanilic acid in cerebrospinal fluid correlates with impaired neuropsychologic function in HIV-1-infected patients.
di Rocco A, Bottiglieri T, Dorfman D, Werner P, Morrison C, Simpson D
Clin Neuropharmacol 2000 Jul-Aug;23(4):190-4. doi: 10.1097/00002826-200007000-00004. PMID: 11020122
Role of serotonin in obsessive-compulsive disorder.
Baumgarten HG, Grozdanovic Z
Br J Psychiatry Suppl 1998;(35):13-20. PMID: 9829022
Biopterin and neurotransmitter amine metabolism in children with acute lymphoblastic leukemia receiving methotrexate therapy.
Pinkerton CR, Smith I, Leeming RJ, Sarna G, Hyland K, Curzon G, Chessells JM
J Pediatr 1986 Mar;108(3):470-4. doi: 10.1016/s0022-3476(86)80904-0. PMID: 2419534
CSF neurotransmitter studies. An infant with ascorbic acid-responsive tyrosinemia.
Stoerner JW, Butler IJ, Morriss FH Jr, Howell RR, Seifert WE Jr, Caprioli RM, Adcock EW 3rd, Denson SE
Am J Dis Child 1980 May;134(5):492-4. doi: 10.1001/archpedi.1980.02130170042014. PMID: 6155067

Prognosis

Mitochondrial diseases mimicking neurotransmitter defects.
Garcia-Cazorla A, Duarte S, Serrano M, Nascimento A, Ormazabal A, Carrilho I, Briones P, Montoya J, Garesse R, Sala-Castellvi P, Pineda M, Artuch R
Mitochondrion 2008 Jun;8(3):273-8. Epub 2008 May 21 doi: 10.1016/j.mito.2008.05.001. PMID: 18558519
Abnormal neurotransmitter metabolite levels in Alzheimer patients with a delirium.
van der Cammen TJ, Tiemeier H, Engelhart MJ, Fekkes D
Int J Geriatr Psychiatry 2006 Sep;21(9):838-43. doi: 10.1002/gps.1569. PMID: 16955437
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder.
Sullivan GM, Oquendo MA, Huang YY, Mann JJ
Int J Neuropsychopharmacol 2006 Oct;9(5):547-56. Epub 2005 Nov 1 doi: 10.1017/S1461145705006231. PMID: 16259647
Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia.
Assmann B, Köhler M, Hoffmann GF, Heales S, Surtees R
Pediatr Res 2002 Jul;52(1):91-4. doi: 10.1203/00006450-200207000-00017. PMID: 12084853
Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa.
Kaye WH, Greeno CG, Moss H, Fernstrom J, Fernstrom M, Lilenfeld LR, Weltzin TE, Mann JJ
Arch Gen Psychiatry 1998 Oct;55(10):927-35. doi: 10.1001/archpsyc.55.10.927. PMID: 9783564

Clinical prediction guides

Lower CSF homovanillic acid relates to higher burden of neuroinflammation and depression in people with HIV disease.
Saloner R, Cherner M, Grelotti DJ, Paolillo EW, Moore DJ, Heaton RK, Letendre SL, Kumar A, Grant I, Ellis RJ
Brain Behav Immun 2020 Nov;90:353-363. Epub 2020 Sep 20 doi: 10.1016/j.bbi.2020.09.012. PMID: 32966871Free PMC Article
Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder.
Ogawa S, Hattori K, Sasayama D, Yokota Y, Matsumura R, Matsuo J, Ota M, Hori H, Teraishi T, Yoshida S, Noda T, Ohashi Y, Sato H, Higuchi T, Motohashi N, Kunugi H
Sci Rep 2015 Jan 15;5:7796. doi: 10.1038/srep07796. PMID: 25589364Free PMC Article
Mitochondrial diseases mimicking neurotransmitter defects.
Garcia-Cazorla A, Duarte S, Serrano M, Nascimento A, Ormazabal A, Carrilho I, Briones P, Montoya J, Garesse R, Sala-Castellvi P, Pineda M, Artuch R
Mitochondrion 2008 Jun;8(3):273-8. Epub 2008 May 21 doi: 10.1016/j.mito.2008.05.001. PMID: 18558519
Selective decrease in central nervous system serotonin turnover in children with dopa-nonresponsive dystonia.
Assmann B, Köhler M, Hoffmann GF, Heales S, Surtees R
Pediatr Res 2002 Jul;52(1):91-4. doi: 10.1203/00006450-200207000-00017. PMID: 12084853
Brain MRI, lumbar CSF monoamine concentrations, and clinical descriptors of patients with spinocerebellar ataxia mutations.
Higgins JJ, Harvey-White JD, Nee LE, Colli MJ, Grossi TA, Kopin IJ
J Neurol Neurosurg Psychiatry 1996 Dec;61(6):591-5. doi: 10.1136/jnnp.61.6.591. PMID: 8971105Free PMC Article

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