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Reduced circulating interleukin 17A concentration

MedGen UID:
1814341
•Concept ID:
C5676772
•
Finding
HPO: HP:0034177

Definition

An abnormally decreased concentration of interleukin 17A in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating interleukin 17A concentration

Conditions with this feature

Immunodeficiency 89 and autoimmunity
MedGen UID:
1794237
•Concept ID:
C5562027
•
Disease or Syndrome
Immunodeficiency-89 and autoimmunity (IMD89) is an autosomal recessive immune disorder characterized by adult onset of recurrent infections, allergies, microcytic anemia, and Crohn disease (see 266600) (Yang et al., 2020).
See: Condition Record
Immunodeficiency 89 and autoimmunity

Professional guidelines

PubMed

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19.
Martonik D, Parfieniuk-Kowerda A, Starosz A, Grubczak K, Moniuszko M, Flisiak R
Front Immunol 2023;14:1222170. Epub 2023 Jul 6 doi: 10.3389/fimmu.2023.1222170. PMID: 37483627Free PMC Article
Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease.
Benschop RJ, Chow CK, Tian Y, Nelson J, Barmettler B, Atwell S, Clawson D, Chai Q, Jones B, Fitchett J, Torgerson S, Ji Y, Bina H, Hu N, Ghanem M, Manetta J, Wroblewski VJ, Lu J, Allan BW
MAbs 2019 Aug/Sep;11(6):1175-1190. Epub 2019 Jun 10 doi: 10.1080/19420862.2019.1624463. PMID: 31181988Free PMC Article

Recent clinical studies

Etiology

Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.
Diehl D, Kaner D, Bockholt A, Bilhan H, Friedmann A
Clin Oral Investig 2023 Mar;27(3):1167-1175. Epub 2022 Oct 13 doi: 10.1007/s00784-022-04731-3. PMID: 36229741Free PMC Article
Changes of Peripheral Th17 Cells Subset in Overweight and Obese Children After Body Weight Reduction.
Artemniak-Wojtowicz D, Kucharska AM, Stelmaszczyk-Emmel A, Majcher A, Pyrżak B
Front Endocrinol (Lausanne) 2022;13:917402. Epub 2022 Jul 6 doi: 10.3389/fendo.2022.917402. PMID: 35873001Free PMC Article
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection.
Romano A, Parrinello NL, Barchitta M, Manuele R, Puglisi F, Maugeri A, Barbato A, Triolo AM, Giallongo C, Tibullo D, La Ferla L, Botta C, Siragusa S, Iacobello C, Montineri A, Volti GL, Agodi A, Palumbo GA, Di Raimondo F
Sci Rep 2022 May 4;12(1):7237. doi: 10.1038/s41598-022-11157-0. PMID: 35508575Free PMC Article
Regulatory T cells and IL-17A levels in noninfectious uveitis.
Guedes MCE, Arroz MJ, Martins C, Angelo-Dias M, Proença RD, Borrego LM
Graefes Arch Clin Exp Ophthalmol 2020 Jun;258(6):1269-1278. Epub 2020 Mar 21 doi: 10.1007/s00417-020-04649-0. PMID: 32200408

Diagnosis

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19.
Martonik D, Parfieniuk-Kowerda A, Starosz A, Grubczak K, Moniuszko M, Flisiak R
Front Immunol 2023;14:1222170. Epub 2023 Jul 6 doi: 10.3389/fimmu.2023.1222170. PMID: 37483627Free PMC Article
Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.
Diehl D, Kaner D, Bockholt A, Bilhan H, Friedmann A
Clin Oral Investig 2023 Mar;27(3):1167-1175. Epub 2022 Oct 13 doi: 10.1007/s00784-022-04731-3. PMID: 36229741Free PMC Article
Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects.
Amoani B, Sakyi SA, Mantey R, Laing EF, Ephraim RD, Sarfo-Katanka O, Koffie S, Obese E, Afranie BO
J Immunoassay Immunochem 2021 May 4;42(3):252-264. Epub 2021 Jan 14 doi: 10.1080/15321819.2020.1862861. PMID: 33444083

Therapy

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19.
Martonik D, Parfieniuk-Kowerda A, Starosz A, Grubczak K, Moniuszko M, Flisiak R
Front Immunol 2023;14:1222170. Epub 2023 Jul 6 doi: 10.3389/fimmu.2023.1222170. PMID: 37483627Free PMC Article
Laquinimod dampens IL-1β signaling and Th17-polarizing capacity of monocytes in patients with MS.
Engel S, Jolivel V, Kraus SH, Zayoud M, Rosenfeld K, Tumani H, Furlan R, Kurschus FC, Waisman A, Luessi F
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Nov 17 doi: 10.1212/NXI.0000000000000908. PMID: 33203651Free PMC Article
Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice.
de Retana SF, Marazuela P, Solé M, Colell G, Bonaterra A, Sánchez-Quesada JL, Montaner J, Maspoch D, Cano-Sarabia M, Hernández-Guillamon M
Alzheimers Res Ther 2019 May 10;11(1):42. doi: 10.1186/s13195-019-0498-8. PMID: 31077261Free PMC Article

Prognosis

Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.
Diehl D, Kaner D, Bockholt A, Bilhan H, Friedmann A
Clin Oral Investig 2023 Mar;27(3):1167-1175. Epub 2022 Oct 13 doi: 10.1007/s00784-022-04731-3. PMID: 36229741Free PMC Article
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection.
Romano A, Parrinello NL, Barchitta M, Manuele R, Puglisi F, Maugeri A, Barbato A, Triolo AM, Giallongo C, Tibullo D, La Ferla L, Botta C, Siragusa S, Iacobello C, Montineri A, Volti GL, Agodi A, Palumbo GA, Di Raimondo F
Sci Rep 2022 May 4;12(1):7237. doi: 10.1038/s41598-022-11157-0. PMID: 35508575Free PMC Article
Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects.
Amoani B, Sakyi SA, Mantey R, Laing EF, Ephraim RD, Sarfo-Katanka O, Koffie S, Obese E, Afranie BO
J Immunoassay Immunochem 2021 May 4;42(3):252-264. Epub 2021 Jan 14 doi: 10.1080/15321819.2020.1862861. PMID: 33444083

Clinical prediction guides

Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization.
Ciudad M, Ouandji S, Lamarthée B, Cladière C, Ghesquière T, Nivet M, Thébault M, Boidot R, Soudry-Faure A, Chevrier S, Richard C, Maillet T, Maurier F, Greigert H, Genet C, Ramon A, Trad M, Predan V, Saas P, Samson M, Bonnotte B, Audia S
Haematologica 2024 Feb 1;109(2):444-457. doi: 10.3324/haematol.2023.282859. PMID: 37534543Free PMC Article
Contribution of IL-38 in Lung Immunity during Pseudomonas Aeruginosa-induced Pneumonia.
Wei Q, Chen X, Chen X, Yuan Z, Wang C
Shock 2022 May 1;57(5):703-713. doi: 10.1097/SHK.0000000000001919. PMID: 35583912
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection.
Romano A, Parrinello NL, Barchitta M, Manuele R, Puglisi F, Maugeri A, Barbato A, Triolo AM, Giallongo C, Tibullo D, La Ferla L, Botta C, Siragusa S, Iacobello C, Montineri A, Volti GL, Agodi A, Palumbo GA, Di Raimondo F
Sci Rep 2022 May 4;12(1):7237. doi: 10.1038/s41598-022-11157-0. PMID: 35508575Free PMC Article
Regulatory T cells and IL-17A levels in noninfectious uveitis.
Guedes MCE, Arroz MJ, Martins C, Angelo-Dias M, Proença RD, Borrego LM
Graefes Arch Clin Exp Ophthalmol 2020 Jun;258(6):1269-1278. Epub 2020 Mar 21 doi: 10.1007/s00417-020-04649-0. PMID: 32200408
Elevated circulating Th17 and follicular helper CD4(+) T cells in patients with rheumatoid arthritis.
Zhang Y, Li Y, Lv TT, Yin ZJ, Wang XB
APMIS 2015 Aug;123(8):659-66. Epub 2015 Apr 27 doi: 10.1111/apm.12399. PMID: 25912557

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