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Reduced circulating interleukin 27 concentration

MedGen UID:
1814338
•Concept ID:
C5676769
•
Finding
HPO: HP:0034174

Definition

An abnormally decreased concentration of interleukin 27 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating interleukin 27 concentration

Conditions with this feature

Immunodeficiency 89 and autoimmunity
MedGen UID:
1794237
•Concept ID:
C5562027
•
Disease or Syndrome
Immunodeficiency-89 and autoimmunity (IMD89) is an autosomal recessive immune disorder characterized by adult onset of recurrent infections, allergies, microcytic anemia, and Crohn disease (see 266600) (Yang et al., 2020).
See: Condition Record
Immunodeficiency 89 and autoimmunity

Recent clinical studies

Etiology

Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease.
Wen Y, Zhang H, Yang N, Gao X, Chen Z, Liu J, Wang G
Front Endocrinol (Lausanne) 2023;14:1173826. Epub 2023 Aug 2 doi: 10.3389/fendo.2023.1173826. PMID: 37600722Free PMC Article

Prognosis

Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease.
Wen Y, Zhang H, Yang N, Gao X, Chen Z, Liu J, Wang G
Front Endocrinol (Lausanne) 2023;14:1173826. Epub 2023 Aug 2 doi: 10.3389/fendo.2023.1173826. PMID: 37600722Free PMC Article

Clinical prediction guides

Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease.
Wen Y, Zhang H, Yang N, Gao X, Chen Z, Liu J, Wang G
Front Endocrinol (Lausanne) 2023;14:1173826. Epub 2023 Aug 2 doi: 10.3389/fendo.2023.1173826. PMID: 37600722Free PMC Article

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