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Anti-cytosolic-5-nucleotidase-1A antibody positivity

MedGen UID:
1814318
•Concept ID:
C5676749
•
Finding
Synonym: Anti-cN1A antibody positivity
 
HPO: HP:0034153

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cytosolic-5-nucleotidase-1A (cN1A). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-cytosolic-5-nucleotidase-1A antibody positivity

Professional guidelines

PubMed

Clinical utility of anti-cytosolic 5'-nucleotidase 1A antibody in idiopathic inflammatory myopathies.
Ikenaga C, Findlay AR, Goyal NA, Robinson S, Cauchi J, Hussain Y, Wang LH, Kershen JC, Beson BA, Wallendorf M, Bucelli RC, Mozaffar T, Pestronk A, Weihl CC
Ann Clin Transl Neurol 2021 Mar;8(3):571-578. Epub 2021 Feb 8 doi: 10.1002/acn3.51294. PMID: 33556224Free PMC Article
Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: Report of 40 patients from a single neuromuscular center.
Felice KJ, Whitaker CH, Wu Q, Larose DT, Shen G, Metzger AL, Barton RW
Neuromuscul Disord 2018 Aug;28(8):660-664. Epub 2018 Jun 18 doi: 10.1016/j.nmd.2018.06.005. PMID: 30001928

Recent clinical studies

Etiology

Myositis-related autoantibody profile and clinical characteristics stratified by anti-cytosolic 5'-nucleotidase 1A status in connective tissue diseases.
Diederichsen LP, Iversen LV, Nielsen CT, Jacobsen S, Hermansen ML, Witting N, Cortes R, Korsholm SS, Krogager ME, Friis T
Muscle Nerve 2023 Jul;68(1):73-80. Epub 2023 May 13 doi: 10.1002/mus.27841. PMID: 37177880
Clinical utility of anti-cytosolic 5'-nucleotidase 1A antibody in idiopathic inflammatory myopathies.
Ikenaga C, Findlay AR, Goyal NA, Robinson S, Cauchi J, Hussain Y, Wang LH, Kershen JC, Beson BA, Wallendorf M, Bucelli RC, Mozaffar T, Pestronk A, Weihl CC
Ann Clin Transl Neurol 2021 Mar;8(3):571-578. Epub 2021 Feb 8 doi: 10.1002/acn3.51294. PMID: 33556224Free PMC Article
Anti-Cytosolic 5'-Nucleotidase 1A Autoantibodies Are Absent in Juvenile Dermatomyositis.
Rietveld A, Wienke J, Visser E, Vree Egberts W, Schlumberger W, van Engelen B, van Royen-Kerkhof A, Lu H, Wedderburn L, Saris C, Tansley S, Pruijn G; Juvenile Dermatomyositis Research Group and the Dutch Myositis Consortium
Arthritis Rheumatol 2021 Jul;73(7):1329-1333. Epub 2021 May 18 doi: 10.1002/art.41660. PMID: 33497020Free PMC Article
Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: Report of 40 patients from a single neuromuscular center.
Felice KJ, Whitaker CH, Wu Q, Larose DT, Shen G, Metzger AL, Barton RW
Neuromuscul Disord 2018 Aug;28(8):660-664. Epub 2018 Jun 18 doi: 10.1016/j.nmd.2018.06.005. PMID: 30001928
Pathomechanisms of anti-cytosolic 5'-nucleotidase 1A autoantibodies in sporadic inclusion body myositis.
Tawara N, Yamashita S, Zhang X, Korogi M, Zhang Z, Doki T, Matsuo Y, Nakane S, Maeda Y, Sugie K, Suzuki N, Aoki M, Ando Y
Ann Neurol 2017 Apr;81(4):512-525. Epub 2017 Apr 3 doi: 10.1002/ana.24919. PMID: 28318044

Diagnosis

Myositis-related autoantibody profile and clinical characteristics stratified by anti-cytosolic 5'-nucleotidase 1A status in connective tissue diseases.
Diederichsen LP, Iversen LV, Nielsen CT, Jacobsen S, Hermansen ML, Witting N, Cortes R, Korsholm SS, Krogager ME, Friis T
Muscle Nerve 2023 Jul;68(1):73-80. Epub 2023 May 13 doi: 10.1002/mus.27841. PMID: 37177880
Clinical utility of anti-cytosolic 5'-nucleotidase 1A antibody in idiopathic inflammatory myopathies.
Ikenaga C, Findlay AR, Goyal NA, Robinson S, Cauchi J, Hussain Y, Wang LH, Kershen JC, Beson BA, Wallendorf M, Bucelli RC, Mozaffar T, Pestronk A, Weihl CC
Ann Clin Transl Neurol 2021 Mar;8(3):571-578. Epub 2021 Feb 8 doi: 10.1002/acn3.51294. PMID: 33556224Free PMC Article
Anti-cN1A antibodies do not correlate with specific clinical, electromyographic, or pathological findings in sporadic inclusion body myositis.
Paul P, Liewluck T, Ernste FC, Mandrekar J, Milone M
Muscle Nerve 2021 Apr;63(4):490-496. Epub 2021 Jan 12 doi: 10.1002/mus.27157. PMID: 33373040
Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: Report of 40 patients from a single neuromuscular center.
Felice KJ, Whitaker CH, Wu Q, Larose DT, Shen G, Metzger AL, Barton RW
Neuromuscul Disord 2018 Aug;28(8):660-664. Epub 2018 Jun 18 doi: 10.1016/j.nmd.2018.06.005. PMID: 30001928

Prognosis

Myositis-related autoantibody profile and clinical characteristics stratified by anti-cytosolic 5'-nucleotidase 1A status in connective tissue diseases.
Diederichsen LP, Iversen LV, Nielsen CT, Jacobsen S, Hermansen ML, Witting N, Cortes R, Korsholm SS, Krogager ME, Friis T
Muscle Nerve 2023 Jul;68(1):73-80. Epub 2023 May 13 doi: 10.1002/mus.27841. PMID: 37177880
Clinical utility of anti-cytosolic 5'-nucleotidase 1A antibody in idiopathic inflammatory myopathies.
Ikenaga C, Findlay AR, Goyal NA, Robinson S, Cauchi J, Hussain Y, Wang LH, Kershen JC, Beson BA, Wallendorf M, Bucelli RC, Mozaffar T, Pestronk A, Weihl CC
Ann Clin Transl Neurol 2021 Mar;8(3):571-578. Epub 2021 Feb 8 doi: 10.1002/acn3.51294. PMID: 33556224Free PMC Article
Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: Report of 40 patients from a single neuromuscular center.
Felice KJ, Whitaker CH, Wu Q, Larose DT, Shen G, Metzger AL, Barton RW
Neuromuscul Disord 2018 Aug;28(8):660-664. Epub 2018 Jun 18 doi: 10.1016/j.nmd.2018.06.005. PMID: 30001928

Clinical prediction guides

Myositis-related autoantibody profile and clinical characteristics stratified by anti-cytosolic 5'-nucleotidase 1A status in connective tissue diseases.
Diederichsen LP, Iversen LV, Nielsen CT, Jacobsen S, Hermansen ML, Witting N, Cortes R, Korsholm SS, Krogager ME, Friis T
Muscle Nerve 2023 Jul;68(1):73-80. Epub 2023 May 13 doi: 10.1002/mus.27841. PMID: 37177880
Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: Report of 40 patients from a single neuromuscular center.
Felice KJ, Whitaker CH, Wu Q, Larose DT, Shen G, Metzger AL, Barton RW
Neuromuscul Disord 2018 Aug;28(8):660-664. Epub 2018 Jun 18 doi: 10.1016/j.nmd.2018.06.005. PMID: 30001928

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