Anti-isoleucyl tRNA-synthetase antibody positivity

MedGen UID:: 1814313
•Concept ID:: C5676744
•: Finding

Synonym:	Anti-OJ antibody positivity

HPO:	HP:0034148

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against isoleucyl tRNA-synthetase. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAnti-isoleucyl tRNA-synthetase antibody positivity

Phenotypic abnormality
- Abnormality of the immune system
  - Abnormality of immune system physiology
    - Autoimmunity
      - Autoimmune antibody positivity
        Anti-aminoacyl-tRNA synthetase antibody positivity
        Anti-isoleucyl tRNA-synthetase antibody positivity

Recent clinical studies

Etiology

Clinical characteristics of anti-isoleucyl-tRNA synthetase antibody associated syndrome and comparison with different patient cohorts.

Ge YP, Zhang YL, Shu XM, Lu X, Wang GC
Clin Exp Rheumatol 2022 Mar;40(3):625-630. Epub 2021 Jun 8 doi: 10.55563/clinexprheumatol/v2rbd0. PMID: 34128807

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Prognosis

The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis.

Kunimasa K, Arita M, Nakazawa T, Tanaka M, Tsubouchi K, Konishi S, Fukuda Y, Saigusa M, Nakagawa H, Ubukata S, Korogi Y, Fujii T, Mimori T, Ishida T
Intern Med 2012;51(24):3405-10. Epub 2012 Dec 15 doi: 10.2169/internalmedicine.51.7452. PMID: 23257529

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