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Anti-nuclear matrix protein-2 antibody positivity

MedGen UID:
1814307
•Concept ID:
C5676738
•
Finding
Synonyms: Anti-MJ/NXP-2 antibody positivity; Anti-NXP-2 antibody positivity
 
HPO: HP:0034142

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NXP-2. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-nuclear matrix protein-2 antibody positivity

Professional guidelines

PubMed

The Role of Myositis-Specific Autoantibodies and the Management of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: A Systematic Review.
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345

Recent clinical studies

Therapy

Anti-NXP2 Antibody-positive Juvenile Dermatomyositis with Characteristic Fascial Thickening on Muscle Ultrasound and Improvement with Immunotherapy.
Fukushima K, Yoshida T, Yamazaki H, Takamatsu N, Nagai T, Osaki Y, Harada M, Nishino I, Okiyama N, Sugie K, Izumi Y
Intern Med 2024 Jun 15;63(12):1813-1817. Epub 2023 Nov 6 doi: 10.2169/internalmedicine.2720-23. PMID: 37926535Free PMC Article
Anti-nuclear matrix protein 2 antibody-positive dermatomyositis with gastrointestinal ulcers: A case report.
Uchio N, Komaki S, Sudo T, Matsumoto Y, Hao A, Kojima K, Toda N, Kitamura A, Maeda MH, Kubota A, Matsumoto H
Int J Rheum Dis 2023 Dec;26(12):2572-2575. Epub 2023 Jun 7 doi: 10.1111/1756-185X.14755. PMID: 37287416
The Role of Myositis-Specific Autoantibodies and the Management of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: A Systematic Review.
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345
Clinical characteristics and poor predictors of anti-NXP2 antibody-associated Chinese JDM children.
Wang X, Ding Y, Zhou Z, Hou J, Xu Y, Li J
Pediatr Rheumatol Online J 2021 Jan 6;19(1):6. doi: 10.1186/s12969-020-00492-z. PMID: 33407621Free PMC Article
Anti-MDA5 autoantibodies associated with juvenile dermatomyositis constitute a distinct phenotype in North America.
Mamyrova G, Kishi T, Shi M, Targoff IN, Huber AM, Curiel RV, Miller FW, Rider LG; Childhood Myositis Heterogeneity Collaborative Study Group
Rheumatology (Oxford) 2021 Apr 6;60(4):1839-1849. doi: 10.1093/rheumatology/keaa429. PMID: 33140079Free PMC Article

Prognosis

Interstitial lung disease in adult patients with anti-NXP2 antibody positivity: a multicentre 18-month follow-up study.
Yan T, Du Y, Sun W, Chen X, Wu Q, Ye Q, Chen S, Xue J
Clin Exp Rheumatol 2023 Mar;41(2):247-253. Epub 2022 Jul 12 doi: 10.55563/clinexprheumatol/lqjx4h. PMID: 35819809
Association of anti-NXP2 antibody with clinical characteristics and outcomes in adult dermatomyositis: results from clinical applications based on a myositis-specific antibody.
Yan TT, Zhang X, Yang HH, Sun WJ, Liu L, Du Y, Xue J
Clin Rheumatol 2021 Sep;40(9):3695-3702. Epub 2021 Mar 13 doi: 10.1007/s10067-021-05667-x. PMID: 33712891
Clinical characteristics and poor predictors of anti-NXP2 antibody-associated Chinese JDM children.
Wang X, Ding Y, Zhou Z, Hou J, Xu Y, Li J
Pediatr Rheumatol Online J 2021 Jan 6;19(1):6. doi: 10.1186/s12969-020-00492-z. PMID: 33407621Free PMC Article
Gastrointestinal perforation in anti-NXP2 antibody-associated juvenile dermatomyositis: case reports and a review of the literature.
Xu Y, Ma X, Zhou Z, Li J, Hou J, Zhu J, Kang M, Lai J, Li X
Pediatr Rheumatol Online J 2021 Jan 6;19(1):2. doi: 10.1186/s12969-020-00486-x. PMID: 33407602Free PMC Article
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Clinical prediction guides

Subsets of Idiopathic Inflammatory Myositis Enriched for Contemporaneous Cancer Relative to the General Population.
Mecoli CA, Igusa T, Chen M, Wang X, Albayda J, Paik JJ, Tiniakou E, Adler B, Richardson C, Kelly W, Danoff S, Mammen AL, Platz EA, Rosen A, Christopher-Stine L, Casciola-Rosen L, Shah AA
Arthritis Rheumatol 2023 Apr;75(4):620-629. Epub 2023 Feb 16 doi: 10.1002/art.42311. PMID: 35878018Free PMC Article
Dermatomyositis: Muscle Pathology According to Antibody Subtypes.
Tanboon J, Inoue M, Saito Y, Tachimori H, Hayashi S, Noguchi S, Okiyama N, Fujimoto M, Nishino I
Neurology 2022 Feb 15;98(7):e739-e749. Epub 2021 Dec 6 doi: 10.1212/WNL.0000000000013176. PMID: 34873015Free PMC Article
Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash.
Ichimura Y, Konishi R, Shobo M, Inoue S, Okune M, Maeda A, Tanaka R, Kubota N, Matsumoto I, Ishii A, Tamaoka A, Shimbo A, Mori M, Morio T, Kishi T, Miyamae T, Tanboon J, Inoue M, Nishino I, Fujimoto M, Nomura T, Okiyama N
Rheumatology (Oxford) 2022 Mar 2;61(3):1222-1227. doi: 10.1093/rheumatology/keab518. PMID: 34152410
Clinical characteristics and poor predictors of anti-NXP2 antibody-associated Chinese JDM children.
Wang X, Ding Y, Zhou Z, Hou J, Xu Y, Li J
Pediatr Rheumatol Online J 2021 Jan 6;19(1):6. doi: 10.1186/s12969-020-00492-z. PMID: 33407621Free PMC Article
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
Satoh M, Tanaka S, Ceribelli A, Calise SJ, Chan EK
Clin Rev Allergy Immunol 2017 Feb;52(1):1-19. doi: 10.1007/s12016-015-8510-y. PMID: 26424665Free PMC Article

Recent systematic reviews

The Role of Myositis-Specific Autoantibodies and the Management of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: A Systematic Review.
Teel A, Lu J, Park J, Singh N, Basharat P
Semin Arthritis Rheum 2022 Dec;57:152088. Epub 2022 Aug 31 doi: 10.1016/j.semarthrit.2022.152088. PMID: 36116345

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