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Anti-insulin antibody positivity

MedGen UID:
1814183
Concept ID:
C5671118
Finding
Synonyms: IAA positivity; Insulin autoantibodies
 
HPO: HP:0034062

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against insulin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-insulin antibody positivity

Professional guidelines

PubMed

Tojjar J, Cervin M, Hedlund E, Brahimi Q, Forsander G, Elding Larsson H, Ludvigsson J, Samuelsson U, Marcus C, Persson M, Carlsson A
Diabetes Care 2023 Nov 1;46(11):1993-1996. doi: 10.2337/dc23-0124. PMID: 37699205
Nieto J, Castillo B, Astudillo M, Tosur M, Balasubramanyam A, Pietropaolo M, Redondo MJ
Pediatr Diabetes 2021 Sep;22(6):882-888. Epub 2021 May 31 doi: 10.1111/pedi.13238. PMID: 34018301
Muscogiuri G, Gastaldelli A
Drugs Today (Barc) 2014 Oct;50(10):665-78. doi: 10.1358/dot.2014.50.10.2214156. PMID: 25374965

Recent clinical studies

Etiology

Tojjar J, Cervin M, Hedlund E, Brahimi Q, Forsander G, Elding Larsson H, Ludvigsson J, Samuelsson U, Marcus C, Persson M, Carlsson A
Diabetes Care 2023 Nov 1;46(11):1993-1996. doi: 10.2337/dc23-0124. PMID: 37699205
Kayhan S, Hepsen S, Kalkisim HK, Sendur IN, Altay FA, Yalcindag A
Arch Endocrinol Metab 2022 Sept 08;66(4):459-465. Epub 2022 Jun 2 doi: 10.20945/2359-3997000000498. PMID: 35657130Free PMC Article
Triolo TM, Pyle L, Broncucia H, Armstrong T, Yu L, Gottlieb PA, Steck AK
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1510-e1517. doi: 10.1210/clinem/dgab853. PMID: 34850014Free PMC Article
Lester M, O'Kell AL
J Small Anim Pract 2020 Apr;61(4):236-240. Epub 2020 Feb 3 doi: 10.1111/jsap.13102. PMID: 32012274
Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group
N Engl J Med 2019 Aug 15;381(7):603-613. Epub 2019 Jun 9 doi: 10.1056/NEJMoa1902226. PMID: 31180194Free PMC Article

Diagnosis

Tachibana M, Imagawa A
Best Pract Res Clin Endocrinol Metab 2022 May;36(3):101657. Epub 2022 Mar 31 doi: 10.1016/j.beem.2022.101657. PMID: 35450793
Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group
N Engl J Med 2019 Aug 15;381(7):603-613. Epub 2019 Jun 9 doi: 10.1056/NEJMoa1902226. PMID: 31180194Free PMC Article
Yuan T, Li J, Li M, Li N, Duan L, Ping F, Li W, Wang L, Zhao W
Clin Ther 2019 May;41(5):920-928. Epub 2019 Apr 13 doi: 10.1016/j.clinthera.2019.03.009. PMID: 30992145
Szosland K, Lewinski A
Neuro Endocrinol Lett 2018 Dec;39(5):355-362. PMID: 30664340
Maraschin Jde F, Murussi N, Witter V, Silveiro SP
Arq Bras Cardiol 2010 Aug;95(2):e40-6. doi: 10.1590/s0066-782x2010001200025. PMID: 20857049

Therapy

Mathieu C, Wiedeman A, Cerosaletti K, Long SA, Serti E, Cooney L, Vermeiren J, Caluwaerts S, Van Huynegem K, Steidler L, Blomme S, Rottiers P, Nepom GT, Herold KC; AG019-T1D-101 Trial Investigators
Diabetologia 2024 Jan;67(1):27-41. Epub 2023 Oct 2 doi: 10.1007/s00125-023-06014-2. PMID: 37782353Free PMC Article
Tachibana M, Imagawa A
Best Pract Res Clin Endocrinol Metab 2022 May;36(3):101657. Epub 2022 Mar 31 doi: 10.1016/j.beem.2022.101657. PMID: 35450793
Sims EK, Bundy BN, Stier K, Serti E, Lim N, Long SA, Geyer SM, Moran A, Greenbaum CJ, Evans-Molina C, Herold KC; Type 1 Diabetes TrialNet Study Group
Sci Transl Med 2021 Mar 3;13(583) doi: 10.1126/scitranslmed.abc8980. PMID: 33658358Free PMC Article
Quattrin T, Haller MJ, Steck AK, Felner EI, Li Y, Xia Y, Leu JH, Zoka R, Hedrick JA, Rigby MR, Vercruysse F; T1GER Study Investigators
N Engl J Med 2020 Nov 19;383(21):2007-2017. doi: 10.1056/NEJMoa2006136. PMID: 33207093
Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group
N Engl J Med 2019 Aug 15;381(7):603-613. Epub 2019 Jun 9 doi: 10.1056/NEJMoa1902226. PMID: 31180194Free PMC Article

Prognosis

Gan L, Zhu X, Gao Y, Zhong M, Liao S, Huang G, Yan Y
Medicine (Baltimore) 2023 Nov 24;102(47):e36273. doi: 10.1097/MD.0000000000036273. PMID: 38013348Free PMC Article
Tachibana M, Imagawa A
Best Pract Res Clin Endocrinol Metab 2022 May;36(3):101657. Epub 2022 Mar 31 doi: 10.1016/j.beem.2022.101657. PMID: 35450793
Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group
N Engl J Med 2019 Aug 15;381(7):603-613. Epub 2019 Jun 9 doi: 10.1056/NEJMoa1902226. PMID: 31180194Free PMC Article
Regnell SE, Lernmark Å
Diabetologia 2017 Aug;60(8):1370-1381. Epub 2017 May 26 doi: 10.1007/s00125-017-4308-1. PMID: 28550517Free PMC Article
Veijola R, Koskinen M, Helminen O, Hekkala A
Pediatr Diabetes 2016 Jul;17 Suppl 22:25-30. doi: 10.1111/pedi.12392. PMID: 27411433

Clinical prediction guides

Kawada-Horitani E, Kita S, Okita T, Nakamura Y, Nishida H, Honma Y, Fukuda S, Tsugawa-Shimizu Y, Kozawa J, Sakaue T, Kawachi Y, Fujishima Y, Nishizawa H, Azuma M, Maeda N, Shimomura I
Diabetologia 2022 Jul;65(7):1185-1197. Epub 2022 May 5 doi: 10.1007/s00125-022-05708-3. PMID: 35511238Free PMC Article
Saito D, Oikawa Y, Mizutani G, Inoue K, Hatano M, Inoue I, Noda M, Shimada A
Endocr J 2019 Apr 25;66(4):329-336. Epub 2019 Feb 14 doi: 10.1507/endocrj.EJ18-0417. PMID: 30760658
Regnell SE, Lernmark Å
Diabetologia 2017 Aug;60(8):1370-1381. Epub 2017 May 26 doi: 10.1007/s00125-017-4308-1. PMID: 28550517Free PMC Article
Muscogiuri G, Gastaldelli A
Drugs Today (Barc) 2014 Oct;50(10):665-78. doi: 10.1358/dot.2014.50.10.2214156. PMID: 25374965
Ziegler AG, Herskowitz RD, Jackson RA, Soeldner JS, Eisenbarth GS
Diabetes Care 1990 Jul;13(7):762-5. doi: 10.2337/diacare.13.7.762. PMID: 2201499

Recent systematic reviews

Martins LM, Fernandes VO, Carvalho MMD, Gadelha DD, Queiroz PC, Montenegro Junior RM
Arch Endocrinol Metab 2020 Aug;64(4):337-348. Epub 2020 Jun 5 doi: 10.20945/2359-3997000000257. PMID: 32813762Free PMC Article
Dong Y, Dai Z, Wang Z, Wang H, Yuan F, Zhu Y, Ye D, Wang B
BMC Pregnancy Childbirth 2019 May 22;19(1):179. doi: 10.1186/s12884-019-2329-0. PMID: 31113392Free PMC Article
Fabrizi F, Donato FM, Messa P
Ann Hepatol 2017 November-December,;16(6):851-861. doi: 10.5604/01.3001.0010.5275. PMID: 29055921
Kolkhir P, Borzova E, Grattan C, Asero R, Pogorelov D, Maurer M
Autoimmun Rev 2017 Dec;16(12):1196-1208. Epub 2017 Oct 14 doi: 10.1016/j.autrev.2017.10.003. PMID: 29037900
Brophy S, Brunt H, Davies H, Mannan S, Williams R
Cochrane Database Syst Rev 2007 Jul 18;(3):CD006165. doi: 10.1002/14651858.CD006165.pub2. PMID: 17636829

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