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Broad medial eyebrow

MedGen UID:
1814112
•Concept ID:
C5558377
•
Finding
Synonym: Medial broadening of eyebrows
 
HPO: HP:0034003

Definition

Regional increase in the width (height) of the middle portion of the eyebrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBroad medial eyebrow

Conditions with this feature

White-Kernohan syndrome
MedGen UID:
1785087
•Concept ID:
C5543635
•
Disease or Syndrome
White-Kernohan syndrome (WHIKERS) is a neurodevelopmental disorder characterized by global developmental delay with variably impaired intellectual development, hypotonia, and characteristic facial features. Some patients may have abnormalities of other systems, including genitourinary and skeletal (summary by White et al., 2021).
See: Condition Record
White-Kernohan syndrome

Professional guidelines

PubMed

Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome.
Maas SM, Shaw AC, Bikker H, Lüdecke HJ, van der Tuin K, Badura-Stronka M, Belligni E, Biamino E, Bonati MT, Carvalho DR, Cobben J, de Man SA, Den Hollander NS, Di Donato N, Garavelli L, Grønborg S, Herkert JC, Hoogeboom AJ, Jamsheer A, Latos-Bielenska A, Maat-Kievit A, Magnani C, Marcelis C, Mathijssen IB, Nielsen M, Otten E, Ousager LB, Pilch J, Plomp A, Poke G, Poluha A, Posmyk R, Rieubland C, Silengo M, Simon M, Steichen E, Stumpel C, Szakszon K, Polonkai E, van den Ende J, van der Steen A, van Essen T, van Haeringen A, van Hagen JM, Verheij JB, Mannens MM, Hennekam RC
Eur J Med Genet 2015 May;58(5):279-92. Epub 2015 Mar 16 doi: 10.1016/j.ejmg.2015.03.002. PMID: 25792522
Clinical features and management issues in Mowat-Wilson syndrome.
Adam MP, Schelley S, Gallagher R, Brady AN, Barr K, Blumberg B, Shieh JT, Graham J, Slavotinek A, Martin M, Keppler-Noreuil K, Storm AL, Hudgins L
Am J Med Genet A 2006 Dec 15;140(24):2730-41. doi: 10.1002/ajmg.a.31530. PMID: 17103451

Recent clinical studies

Etiology

Clinical findings in cases with 9q deletion encompassing the 9q21.11q21.32 region.
Tuğ E, Ergün MA, Perçin EF
Turk J Pediatr 2018;60(1):94-98. doi: 10.24953/turkjped.2018.01.015. PMID: 30102487
Chromosome 15q24 microdeletion syndrome.
Magoulas PL, El-Hattab AW
Orphanet J Rare Dis 2012 Jan 4;7:2. doi: 10.1186/1750-1172-7-2. PMID: 22216833Free PMC Article
Video endoscopic-assisted brow lift: comparison of the eyebrow position after Endotine tissue fixation versus suture fixation.
Hönig JF, Frank MH, Knutti D, de La Fuente A
J Craniofac Surg 2008 Jul;19(4):1140-7. doi: 10.1097/SCS.0b013e3181764b19. PMID: 18650749
Ocular findings in a 4 p- deletion syndrome (Wolf-Hirschhorn).
Mayer UM, Bialasiewicz AA
Ophthalmic Paediatr Genet 1989 Mar;10(1):69-72. doi: 10.3109/13816818909083777. PMID: 2787011
A new method for telecanthus correction in Waardenburg syndrome.
Lessa S, Carreirão S
Ann Plast Surg 1981 Jun;6(6):482-90. doi: 10.1097/00000637-198106000-00011. PMID: 6791571

Diagnosis

Trauma due to Self-aggression in Patient with Waardenburg Syndrome associated with Congenital Anomalies.
Marta SN, Kawakami RY, Sgavioli CA, Correa AE, D'Árk de Oliveira El Kadre G, Carvalho RS
J Contemp Dent Pract 2016 Aug 1;17(8):702-5. doi: 10.5005/jp-journals-10024-1915. PMID: 27659091
Barber-Say syndrome and Ablepharon-Macrostomia syndrome: An overview.
De Maria B, Mazzanti L, Roche N, Hennekam RC
Am J Med Genet A 2016 Aug;170(8):1989-2001. Epub 2016 May 19 doi: 10.1002/ajmg.a.37757. PMID: 27196381
Chromosome 15q24 microdeletion syndrome.
Magoulas PL, El-Hattab AW
Orphanet J Rare Dis 2012 Jan 4;7:2. doi: 10.1186/1750-1172-7-2. PMID: 22216833Free PMC Article
Characterization of a recurrent 15q24 microdeletion syndrome.
Sharp AJ, Selzer RR, Veltman JA, Gimelli S, Gimelli G, Striano P, Coppola A, Regan R, Price SM, Knoers NV, Eis PS, Brunner HG, Hennekam RC, Knight SJ, de Vries BB, Zuffardi O, Eichler EE
Hum Mol Genet 2007 Mar 1;16(5):567-72. Epub 2007 Mar 14 doi: 10.1093/hmg/ddm016. PMID: 17360722
Clinical features and management issues in Mowat-Wilson syndrome.
Adam MP, Schelley S, Gallagher R, Brady AN, Barr K, Blumberg B, Shieh JT, Graham J, Slavotinek A, Martin M, Keppler-Noreuil K, Storm AL, Hudgins L
Am J Med Genet A 2006 Dec 15;140(24):2730-41. doi: 10.1002/ajmg.a.31530. PMID: 17103451

Prognosis

Chromosome 15q24 microdeletion syndrome.
Magoulas PL, El-Hattab AW
Orphanet J Rare Dis 2012 Jan 4;7:2. doi: 10.1186/1750-1172-7-2. PMID: 22216833Free PMC Article
Ocular findings in a 4 p- deletion syndrome (Wolf-Hirschhorn).
Mayer UM, Bialasiewicz AA
Ophthalmic Paediatr Genet 1989 Mar;10(1):69-72. doi: 10.3109/13816818909083777. PMID: 2787011

Clinical prediction guides

De novo KAT6B mutation causes Say-Barber-Biesecker-Young-Simpson variant of Ohdo syndrome in an Iranian boy: a case report.
Davarnia B, Panahi M, Rahimi B, Anari H, Farajollahi R, Rodbaneh EA, Jeddi F
J Med Case Rep 2024 Jan 5;18(1):4. doi: 10.1186/s13256-023-04237-w. PMID: 38178270Free PMC Article
Trauma due to Self-aggression in Patient with Waardenburg Syndrome associated with Congenital Anomalies.
Marta SN, Kawakami RY, Sgavioli CA, Correa AE, D'Árk de Oliveira El Kadre G, Carvalho RS
J Contemp Dent Pract 2016 Aug 1;17(8):702-5. doi: 10.5005/jp-journals-10024-1915. PMID: 27659091
Chromosome 15q24 microdeletion syndrome.
Magoulas PL, El-Hattab AW
Orphanet J Rare Dis 2012 Jan 4;7:2. doi: 10.1186/1750-1172-7-2. PMID: 22216833Free PMC Article
Video endoscopic-assisted brow lift: comparison of the eyebrow position after Endotine tissue fixation versus suture fixation.
Hönig JF, Frank MH, Knutti D, de La Fuente A
J Craniofac Surg 2008 Jul;19(4):1140-7. doi: 10.1097/SCS.0b013e3181764b19. PMID: 18650749
Ocular findings in a 4 p- deletion syndrome (Wolf-Hirschhorn).
Mayer UM, Bialasiewicz AA
Ophthalmic Paediatr Genet 1989 Mar;10(1):69-72. doi: 10.3109/13816818909083777. PMID: 2787011

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