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ALECT2 amyloidosis

MedGen UID:
1801621
•Concept ID:
C5680047
•
Disease or Syndrome
Synonyms: LECT2 amyloidosis; Leukocyte chemotactic factor-2 amyloidosis; leukocyte chemotactic factor-2 amyloidosis
SNOMED CT: ALECT2 amyloidosis (1228881003); Leukocyte chemotactic factor-2 amyloidosis (1228881003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018588
Orphanet: ORPHA439224

Definition

A rare systemic amyloidosis with characteristics of slowly progressive renal disease presenting with proteinuria, hypertension and decreased glomerular filtration rate leading to progressive renal failure. Histology reveals amyloid deposits of leukocyte chemotactic factor-2 protein in the renal cortical interstitium, tubular basement membranes, glomeruli and the vessel walls. Extra-renal deposits can be seen in the liver, lungs, spleen and adrenal glands. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVALECT2 amyloidosis

Professional guidelines

PubMed

AL amyloidosis: advances in diagnostics and treatment.
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492

Recent clinical studies

Etiology

LECT-2 amyloidosis: what do we know?
Mann BK, Bhandohal JS, Cobos E, Chitturi C, Eppanapally S
J Investig Med 2022 Feb;70(2):348-353. Epub 2021 Nov 30 doi: 10.1136/jim-2021-002149. PMID: 34848562
Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis.
Rezk T, Gilbertson JA, Rowczenio D, Bass P, Lachmann HJ, Wechalekar AD, Fontana M, Mahmood S, Sachchithanantham S, Whelan CJ, Wong J, Rendell N, Taylor GW, Hawkins PN, Gillmore JD
Nephrol Dial Transplant 2018 Feb 1;33(2):241-247. doi: 10.1093/ndt/gfw375. PMID: 29401357
Pathology and diagnosis of renal non-AL amyloidosis.
Sethi S, Theis JD
J Nephrol 2018 Jun;31(3):343-350. Epub 2017 Aug 21 doi: 10.1007/s40620-017-0426-6. PMID: 28828707
Amyloidosis: Insights from Proteomics.
Dogan A
Annu Rev Pathol 2017 Jan 24;12:277-304. Epub 2016 Dec 5 doi: 10.1146/annurev-pathol-052016-100200. PMID: 27959636
Leukocyte Cell-Derived Chemotaxin 2-Associated Amyloidosis: A Recently Recognized Disease with Distinct Clinicopathologic Characteristics.
Nasr SH, Dogan A, Larsen CP
Clin J Am Soc Nephrol 2015 Nov 6;10(11):2084-93. Epub 2015 Apr 14 doi: 10.2215/CJN.12551214. PMID: 25873265Free PMC Article

Diagnosis

LECT-2 amyloidosis: what do we know?
Mann BK, Bhandohal JS, Cobos E, Chitturi C, Eppanapally S
J Investig Med 2022 Feb;70(2):348-353. Epub 2021 Nov 30 doi: 10.1136/jim-2021-002149. PMID: 34848562
Renal leukocyte chemotactic factor 2 (ALECT2)-associated amyloidosis in Chinese patients.
Li DY, Liu D, Wang SX, Yu XJ, Cui Z, Zhou FD, Zhao MH
Amyloid 2020 Jun;27(2):134-141. Epub 2020 Feb 5 doi: 10.1080/13506129.2020.1722097. PMID: 32024381
Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis.
Rezk T, Gilbertson JA, Rowczenio D, Bass P, Lachmann HJ, Wechalekar AD, Fontana M, Mahmood S, Sachchithanantham S, Whelan CJ, Wong J, Rendell N, Taylor GW, Hawkins PN, Gillmore JD
Nephrol Dial Transplant 2018 Feb 1;33(2):241-247. doi: 10.1093/ndt/gfw375. PMID: 29401357
Pathology and diagnosis of renal non-AL amyloidosis.
Sethi S, Theis JD
J Nephrol 2018 Jun;31(3):343-350. Epub 2017 Aug 21 doi: 10.1007/s40620-017-0426-6. PMID: 28828707
Amyloidosis: Insights from Proteomics.
Dogan A
Annu Rev Pathol 2017 Jan 24;12:277-304. Epub 2016 Dec 5 doi: 10.1146/annurev-pathol-052016-100200. PMID: 27959636

Therapy

Clinically occult amyloidosis derived from leukocyte chemotactic factor 2 (ALECT 2) with cardiac involvement complicating renal transplantation: case report and literature review.
Eletta O, Ali M, Grieff A, Puri S, Matsuda K, Bongu A, Fyfe B
Cardiovasc Pathol 2021 Nov-Dec;55:107375. Epub 2021 Aug 8 doi: 10.1016/j.carpath.2021.107375. PMID: 34371188

Prognosis

Clinically occult amyloidosis derived from leukocyte chemotactic factor 2 (ALECT 2) with cardiac involvement complicating renal transplantation: case report and literature review.
Eletta O, Ali M, Grieff A, Puri S, Matsuda K, Bongu A, Fyfe B
Cardiovasc Pathol 2021 Nov-Dec;55:107375. Epub 2021 Aug 8 doi: 10.1016/j.carpath.2021.107375. PMID: 34371188
Delving into the amyloidogenic core of human leukocyte chemotactic factor 2.
Tsiolaki PL, Nasi GI, Baltoumas FA, Fishman S, Tu HC, Iconomidou VA
J Struct Biol 2019 Sep 1;207(3):260-269. Epub 2019 Jun 3 doi: 10.1016/j.jsb.2019.06.001. PMID: 31170474
Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis.
Rezk T, Gilbertson JA, Rowczenio D, Bass P, Lachmann HJ, Wechalekar AD, Fontana M, Mahmood S, Sachchithanantham S, Whelan CJ, Wong J, Rendell N, Taylor GW, Hawkins PN, Gillmore JD
Nephrol Dial Transplant 2018 Feb 1;33(2):241-247. doi: 10.1093/ndt/gfw375. PMID: 29401357
Pathology and diagnosis of renal non-AL amyloidosis.
Sethi S, Theis JD
J Nephrol 2018 Jun;31(3):343-350. Epub 2017 Aug 21 doi: 10.1007/s40620-017-0426-6. PMID: 28828707

Clinical prediction guides

Delving into the amyloidogenic core of human leukocyte chemotactic factor 2.
Tsiolaki PL, Nasi GI, Baltoumas FA, Fishman S, Tu HC, Iconomidou VA
J Struct Biol 2019 Sep 1;207(3):260-269. Epub 2019 Jun 3 doi: 10.1016/j.jsb.2019.06.001. PMID: 31170474

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