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Metastatic Hydatidiform Mole

MedGen UID:
1792955
•Concept ID:
C5556514
•
Neoplastic Process

Definition

The spread of abnormal molar chorionic villi from an invasive hydatidiform mole in the uterine cavity to other anatomic sites, usually the vaginal wall and pelvis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Hydatidiform Mole

Professional guidelines

PubMed

Current status of treatment of gestational trophoblastic disease.
Lewis JL Jr
Cancer 1976 Jul;38(1 SUPPL):620-6. doi: 10.1002/1097-0142(197607)38:1<620::aid-cncr2820380187>3.0.co;2-p. PMID: 179695

Recent clinical studies

Etiology

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Clinical presentation and diagnosis of Gestational Trophoblastic Disease.
Lok C, Frijstein M, van Trommel N
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:42-52. Epub 2020 Dec 21 doi: 10.1016/j.bpobgyn.2020.12.001. PMID: 33422446
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Gestational trophoblastic disease.
Berkowitz RS, Goldstein DP
Cancer 1995 Nov 15;76(10 Suppl):2079-85. doi: 10.1002/1097-0142(19951115)76:10+<2079::aid-cncr2820761329>3.0.co;2-o. PMID: 8635004
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Diagnosis

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Imaging in Gestational Trophoblastic Disease.
Lin LH, Polizio R, Fushida K, Francisco RPV
Semin Ultrasound CT MR 2019 Aug;40(4):332-349. Epub 2019 Mar 5 doi: 10.1053/j.sult.2019.03.002. PMID: 31375173
Gestational trophoblastic disease.
Berkowitz RS, Goldstein DP
Cancer 1995 Nov 15;76(10 Suppl):2079-85. doi: 10.1002/1097-0142(19951115)76:10+<2079::aid-cncr2820761329>3.0.co;2-o. PMID: 8635004

Therapy

Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Gestational trophoblastic disease.
Gerulath AH, Ehlen TG, Bessette P, Jolicoeur L, Savoie R; Society of Obstetricians and Gynaecologists of Canada; Gynaecologic Oncologists of Canada; Society of Canadian Colposcopists
J Obstet Gynaecol Can 2002 May;24(5):434-46. PMID: 12196865
Gestational trophoblastic disease.
Berkowitz RS, Goldstein DP
Cancer 1995 Nov 15;76(10 Suppl):2079-85. doi: 10.1002/1097-0142(19951115)76:10+<2079::aid-cncr2820761329>3.0.co;2-o. PMID: 8635004
Gestational trophoblastic tumors.
Rustin GJ, Bagshawe KD
Crit Rev Oncol Hematol 1985;3(2):103-42. doi: 10.1016/s1040-8428(85)80022-6. PMID: 2992827
Gestational trophoblastic neoplasms.
Hilgers RD, Lewis JL Jr
Gynecol Oncol 1974 Dec;2(4):460-75. doi: 10.1016/0090-8258(74)90055-9. PMID: 4376997

Prognosis

Invasive and metastatic hydatidiform moles in Slovakia in 1993‒2022.
McCullough L, Danihel L, Sufliarsky J, Kubickova M, Niznanska Z, Adamec A, Korbel M
Bratisl Lek Listy 2024;125(7):423-428. doi: 10.4149/BLL_2024_65. PMID: 38943503
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Gestational trophoblastic disease.
Gerulath AH, Ehlen TG, Bessette P, Jolicoeur L, Savoie R; Society of Obstetricians and Gynaecologists of Canada; Gynaecologic Oncologists of Canada; Society of Canadian Colposcopists
J Obstet Gynaecol Can 2002 May;24(5):434-46. PMID: 12196865
Gestational trophoblastic tumors.
Rustin GJ, Bagshawe KD
Crit Rev Oncol Hematol 1985;3(2):103-42. doi: 10.1016/s1040-8428(85)80022-6. PMID: 2992827

Clinical prediction guides

MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN : MicroRNA Profile in Postmolar GTN.
Teerapakpinyo C, Areeruk W, Tantbirojn P, Phupong V, Shuangshoti S, Lertkhachonsuk R
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338211067309. doi: 10.1177/15330338211067309. PMID: 35023789Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Diagnosis and Management of Gestational Trophoblastic Disease: A Comparative Review of National and International Guidelines.
Tsakiridis I, Giouleka S, Kalogiannidis I, Mamopoulos A, Athanasiadis A, Dagklis T
Obstet Gynecol Surv 2020 Dec;75(12):747-756. doi: 10.1097/OGX.0000000000000848. PMID: 33369685
Radiology of gestational trophoblastic neoplasia.
Allen SD, Lim AK, Seckl MJ, Blunt DM, Mitchell AW
Clin Radiol 2006 Apr;61(4):301-13. doi: 10.1016/j.crad.2005.12.003. PMID: 16546459
Pharmacotherapy of gestational trophoblastic disease.
Lurain JR
Expert Opin Pharmacother 2003 Nov;4(11):2005-17. doi: 10.1517/14656566.4.11.2005. PMID: 14596654

Recent systematic reviews

Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

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