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Microsatellite Stable Rectal Carcinoma

MedGen UID:
1791054
Concept ID:
C5554613
Neoplastic Process

Definition

Rectal carcinoma characterized by the absence of microsatellite instability. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrosatellite Stable Rectal Carcinoma

Professional guidelines

PubMed

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Xiao W, Luo H, Yao Y, Wang Y, Liu S, Sun R, Chen G
Front Immunol 2023;14:1149122. Epub 2023 Mar 24 doi: 10.3389/fimmu.2023.1149122. PMID: 37033988Free PMC Article
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article

Recent clinical studies

Etiology

Cornish AJ, Gruber AJ, Kinnersley B, Chubb D, Frangou A, Caravagna G, Noyvert B, Lakatos E, Wood HM, Thorn S, Culliford R, Arnedo-Pac C, Househam J, Cross W, Sud A, Law P, Leathlobhair MN, Hawari A, Woolley C, Sherwood K, Feeley N, Gül G, Fernandez-Tajes J, Zapata L, Alexandrov LB, Murugaesu N, Sosinsky A, Mitchell J, Lopez-Bigas N, Quirke P, Church DN, Tomlinson IPM, Sottoriva A, Graham TA, Wedge DC, Houlston RS
Nature 2024 Sep;633(8028):127-136. Epub 2024 Aug 7 doi: 10.1038/s41586-024-07747-9. PMID: 39112709Free PMC Article
Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
Chatila WK, Kim JK, Walch H, Marco MR, Chen CT, Wu F, Omer DM, Khalil DN, Ganesh K, Qu X, Luthra A, Choi SH, Ho YJ, Kundra R, Groves KI, Chow OS, Cercek A, Weiser MR, Widmar M, Wei IH, Pappou EP, Nash GM, Paty PB, Shi Q, Vakiani E, Duygu Selcuklu S, Donoghue MTA, Solit DB, Berger MF, Shia J, Pelossof R, Romesser PB, Yaeger R, Smith JJ, Schultz N, Sanchez-Vega F, Garcia-Aguilar J
Nat Med 2022 Aug;28(8):1646-1655. Epub 2022 Aug 15 doi: 10.1038/s41591-022-01930-z. PMID: 35970919Free PMC Article
Antoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoué C, Aprile G, Antonuzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C; GONO Foundation Investigators
Lancet Oncol 2022 Jul;23(7):876-887. Epub 2022 May 27 doi: 10.1016/S1470-2045(22)00274-1. PMID: 35636444

Diagnosis

Hitchcock KE, Miller ED, Shi Q, Dixon JG, Gholami S, White SB, Wu C, Goulet CC, George M, Jee KW, Wright CL, Yaeger R, Shergill A, Hong TS, George TJ, O'Reilly EM, Meyerhardt JA, Romesser PB
BMC Cancer 2024 Feb 13;24(1):201. doi: 10.1186/s12885-024-11899-2. PMID: 38350888Free PMC Article
Reitsam NG, Grozdanov V, Löffler CML, Muti HS, Grosser B, Kather JN, Märkl B
Cancer Gene Ther 2024 Feb;31(2):207-216. Epub 2023 Nov 22 doi: 10.1038/s41417-023-00695-y. PMID: 37990064Free PMC Article
Chen EX, Loree JM, Titmuss E, Jonker DJ, Kennecke HF, Berry S, Couture F, Ahmad CE, Goffin JR, Kavan P, Harb M, Colwell B, Samimi S, Samson B, Abbas T, Aucoin N, Aubin F, Koski S, Wei AC, Tu D, O'Callaghan CJ
JAMA Netw Open 2023 Dec 1;6(12):e2346094. doi: 10.1001/jamanetworkopen.2023.46094. PMID: 38051531Free PMC Article
Cercek A, Chatila WK, Yaeger R, Walch H, Fernandes GDS, Krishnan A, Palmaira L, Maio A, Kemel Y, Srinivasan P, Bandlamudi C, Salo-Mullen E, Tejada PR, Belanfanti K, Galle J, Joseph V, Segal N, Varghese A, Reidy-Lagunes D, Shia J, Vakiani E, Mondaca S, Mendelsohn R, Lumish MA, Steinruecke F, Kemeny N, Connell L, Ganesh K, Markowitz A, Nash G, Guillem J, Smith JJ, Paty PB, Zhang L, Mandelker D, Birsoy O, Robson M, Offit K, Taylor B, Berger M, Solit D, Weiser M, Saltz LB, Aguilar JG, Schultz N, Diaz LA, Stadler ZK
J Natl Cancer Inst 2021 Nov 29;113(12):1683-1692. doi: 10.1093/jnci/djab124. PMID: 34405229Free PMC Article
Cercek A, Dos Santos Fernandes G, Roxburgh CS, Ganesh K, Ng S, Sanchez-Vega F, Yaeger R, Segal NH, Reidy-Lagunes DL, Varghese AM, Markowitz A, Wu C, Szeglin B, Sauvé CG, Salo-Mullen E, Tran C, Patel Z, Krishnan A, Tkachuk K, Nash GM, Guillem J, Paty PB, Shia J, Schultz N, Garcia-Aguilar J, Diaz LA, Goodman K, Saltz LB, Weiser MR, Smith JJ, Stadler ZK
Clin Cancer Res 2020 Jul 1;26(13):3271-3279. Epub 2020 Mar 6 doi: 10.1158/1078-0432.CCR-19-3728. PMID: 32144135Free PMC Article

Therapy

Cornish AJ, Gruber AJ, Kinnersley B, Chubb D, Frangou A, Caravagna G, Noyvert B, Lakatos E, Wood HM, Thorn S, Culliford R, Arnedo-Pac C, Househam J, Cross W, Sud A, Law P, Leathlobhair MN, Hawari A, Woolley C, Sherwood K, Feeley N, Gül G, Fernandez-Tajes J, Zapata L, Alexandrov LB, Murugaesu N, Sosinsky A, Mitchell J, Lopez-Bigas N, Quirke P, Church DN, Tomlinson IPM, Sottoriva A, Graham TA, Wedge DC, Houlston RS
Nature 2024 Sep;633(8028):127-136. Epub 2024 Aug 7 doi: 10.1038/s41586-024-07747-9. PMID: 39112709Free PMC Article
Lin KX, Istl AC, Quan D, Skaro A, Tang E, Zheng X
Cancer Immunol Immunother 2023 Dec;72(12):3875-3893. Epub 2023 Oct 13 doi: 10.1007/s00262-023-03520-5. PMID: 37831146Free PMC Article
Kasi PM, Hidalgo M, Jafari MD, Yeo H, Lowenfeld L, Khan U, Nguyen ATH, Siolas D, Swed B, Hyun J, Khan S, Wood M, Samstein B, Rocca JP, Ocean AJ, Popa EC, Hunt DH, Uppal NP, Garrett KA, Pigazzi A, Zhou XK, Shah MA, Hissong E
Oncogene 2023 Oct;42(44):3252-3259. Epub 2023 Sep 21 doi: 10.1038/s41388-023-02835-y. PMID: 37731056Free PMC Article
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article

Prognosis

Cornish AJ, Gruber AJ, Kinnersley B, Chubb D, Frangou A, Caravagna G, Noyvert B, Lakatos E, Wood HM, Thorn S, Culliford R, Arnedo-Pac C, Househam J, Cross W, Sud A, Law P, Leathlobhair MN, Hawari A, Woolley C, Sherwood K, Feeley N, Gül G, Fernandez-Tajes J, Zapata L, Alexandrov LB, Murugaesu N, Sosinsky A, Mitchell J, Lopez-Bigas N, Quirke P, Church DN, Tomlinson IPM, Sottoriva A, Graham TA, Wedge DC, Houlston RS
Nature 2024 Sep;633(8028):127-136. Epub 2024 Aug 7 doi: 10.1038/s41586-024-07747-9. PMID: 39112709Free PMC Article
Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Emiloju OE, Zhu M, Xie H, Jin Z, Sinicrope FA, Hubbard JM
Curr Treat Options Oncol 2023 Dec;24(12):1739-1757. Epub 2023 Nov 15 doi: 10.1007/s11864-023-01142-8. PMID: 37966682
Bando H, Tsukada Y, Inamori K, Togashi Y, Koyama S, Kotani D, Fukuoka S, Yuki S, Komatsu Y, Homma S, Taketomi A, Uemura M, Kato T, Fukui M, Wakabayashi M, Nakamura N, Kojima M, Kawachi H, Kirsch R, Yoshida T, Suzuki Y, Sato A, Nishikawa H, Ito M, Yoshino T
Clin Cancer Res 2022 Mar 15;28(6):1136-1146. doi: 10.1158/1078-0432.CCR-21-3213. PMID: 35063964Free PMC Article
Cercek A, Chatila WK, Yaeger R, Walch H, Fernandes GDS, Krishnan A, Palmaira L, Maio A, Kemel Y, Srinivasan P, Bandlamudi C, Salo-Mullen E, Tejada PR, Belanfanti K, Galle J, Joseph V, Segal N, Varghese A, Reidy-Lagunes D, Shia J, Vakiani E, Mondaca S, Mendelsohn R, Lumish MA, Steinruecke F, Kemeny N, Connell L, Ganesh K, Markowitz A, Nash G, Guillem J, Smith JJ, Paty PB, Zhang L, Mandelker D, Birsoy O, Robson M, Offit K, Taylor B, Berger M, Solit D, Weiser M, Saltz LB, Aguilar JG, Schultz N, Diaz LA, Stadler ZK
J Natl Cancer Inst 2021 Nov 29;113(12):1683-1692. doi: 10.1093/jnci/djab124. PMID: 34405229Free PMC Article

Clinical prediction guides

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Yu JH, Xiao BY, Li DD, Jiang W, Ding Y, Wu XJ, Zhang RX, Lin JZ, Wang W, Han K, Kong LH, Zhang XK, Chen BY, Mei WJ, Pan ZZ, Tang JH, Zhang XS, Ding PR
Lancet Oncol 2024 Jul;25(7):843-852. Epub 2024 Jun 6 doi: 10.1016/S1470-2045(24)00203-1. PMID: 38852601
Emiloju OE, Zhu M, Xie H, Jin Z, Sinicrope FA, Hubbard JM
Curr Treat Options Oncol 2023 Dec;24(12):1739-1757. Epub 2023 Nov 15 doi: 10.1007/s11864-023-01142-8. PMID: 37966682
Kasi PM, Hidalgo M, Jafari MD, Yeo H, Lowenfeld L, Khan U, Nguyen ATH, Siolas D, Swed B, Hyun J, Khan S, Wood M, Samstein B, Rocca JP, Ocean AJ, Popa EC, Hunt DH, Uppal NP, Garrett KA, Pigazzi A, Zhou XK, Shah MA, Hissong E
Oncogene 2023 Oct;42(44):3252-3259. Epub 2023 Sep 21 doi: 10.1038/s41388-023-02835-y. PMID: 37731056Free PMC Article
Bando H, Tsukada Y, Inamori K, Togashi Y, Koyama S, Kotani D, Fukuoka S, Yuki S, Komatsu Y, Homma S, Taketomi A, Uemura M, Kato T, Fukui M, Wakabayashi M, Nakamura N, Kojima M, Kawachi H, Kirsch R, Yoshida T, Suzuki Y, Sato A, Nishikawa H, Ito M, Yoshino T
Clin Cancer Res 2022 Mar 15;28(6):1136-1146. doi: 10.1158/1078-0432.CCR-21-3213. PMID: 35063964Free PMC Article

Recent systematic reviews

Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S
J Clin Oncol 2024 Oct;42(28):3355-3375. Epub 2024 Aug 8 doi: 10.1200/JCO.24.01160. PMID: 39116386
Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899Free PMC Article
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Swets M, Graham Martinez C, van Vliet S, van Tilburg A, Gelderblom H, Marijnen CAM, van de Velde CJH, Nagtegaal ID
Histopathology 2022 Sep;81(3):352-362. Epub 2022 Jul 14 doi: 10.1111/his.14710. PMID: 35758193Free PMC Article
O'Connell E, Reynolds IS, McNamara DA, Prehn JHM, Burke JP
Surg Oncol 2020 Sep;34:57-62. Epub 2020 Apr 2 doi: 10.1016/j.suronc.2020.03.009. PMID: 32891354

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