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Glomerular fibrinoid necrosis

MedGen UID:
1788288
•Concept ID:
C5539475
•
Pathologic Function
HPO: HP:0033277

Definition

Fibrin associated with glomerular basement membrane disruption and/or lysis of the mesangial matrix; this lesion does not require the presence of karyorrhexis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular fibrinoid necrosis

Professional guidelines

PubMed

Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices.
Bajema IM, Wilhelmus S, Alpers CE, Bruijn JA, Colvin RB, Cook HT, D'Agati VD, Ferrario F, Haas M, Jennette JC, Joh K, Nast CC, Noël LH, Rijnink EC, Roberts ISD, Seshan SV, Sethi S, Fogo AB
Kidney Int 2018 Apr;93(4):789-796. Epub 2018 Feb 16 doi: 10.1016/j.kint.2017.11.023. PMID: 29459092
Differential expression of tissue factor (TF) in calcineurin inhibitor-induced nephrotoxicity and rejection--implications for development of a possible diagnostic marker.
Osterholm C, Veress B, Simanaitis M, Hedner U, Ekberg H
Transpl Immunol 2005 Dec;15(2):165-72. Epub 2005 Jun 29 doi: 10.1016/j.trim.2005.06.001. PMID: 16412961
Prospective measurement of glomerular filtration rate and effective renal plasma flow during treatment of malignant essential hypertension.
Ghose RR
Postgrad Med J 1984 Oct;60(708):662-4. doi: 10.1136/pgmj.60.708.662. PMID: 6494086Free PMC Article

Recent clinical studies

Etiology

Characteristics and influence factors of pathologic transformation in the subclasses of class IV lupus nephritis.
Gao JJ, Cai GY, Liu SW, Tang L, Zhang XG, Yang Y, Chen P, Liu SX, Ji JY, Shi SZ, Yin Z, Chen XM
Rheumatol Int 2012 Jun;32(6):1751-9. Epub 2011 Mar 26 doi: 10.1007/s00296-011-1899-6. PMID: 21442167
Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center.
Yu F, Tan Y, Wu LH, Zhu SN, Liu G, Zhao MH
Lupus 2009 Oct;18(12):1073-81. doi: 10.1177/0961203309106795. PMID: 19762381
Clinical and pathological characterization of patients with microscopic polyangiitis with medium artery involvement.
Zhao MH, Sun QZ, Wang HY
Ren Fail 2003 Nov;25(6):989-95. doi: 10.1081/jdi-120026034. PMID: 14669858

Diagnosis

Characteristics and influence factors of pathologic transformation in the subclasses of class IV lupus nephritis.
Gao JJ, Cai GY, Liu SW, Tang L, Zhang XG, Yang Y, Chen P, Liu SX, Ji JY, Shi SZ, Yin Z, Chen XM
Rheumatol Int 2012 Jun;32(6):1751-9. Epub 2011 Mar 26 doi: 10.1007/s00296-011-1899-6. PMID: 21442167
Clinical and pathological characterization of patients with microscopic polyangiitis with medium artery involvement.
Zhao MH, Sun QZ, Wang HY
Ren Fail 2003 Nov;25(6):989-95. doi: 10.1081/jdi-120026034. PMID: 14669858

Therapy

Characteristics and influence factors of pathologic transformation in the subclasses of class IV lupus nephritis.
Gao JJ, Cai GY, Liu SW, Tang L, Zhang XG, Yang Y, Chen P, Liu SX, Ji JY, Shi SZ, Yin Z, Chen XM
Rheumatol Int 2012 Jun;32(6):1751-9. Epub 2011 Mar 26 doi: 10.1007/s00296-011-1899-6. PMID: 21442167
Clinical and pathological characterization of patients with microscopic polyangiitis with medium artery involvement.
Zhao MH, Sun QZ, Wang HY
Ren Fail 2003 Nov;25(6):989-95. doi: 10.1081/jdi-120026034. PMID: 14669858

Prognosis

Characteristics and influence factors of pathologic transformation in the subclasses of class IV lupus nephritis.
Gao JJ, Cai GY, Liu SW, Tang L, Zhang XG, Yang Y, Chen P, Liu SX, Ji JY, Shi SZ, Yin Z, Chen XM
Rheumatol Int 2012 Jun;32(6):1751-9. Epub 2011 Mar 26 doi: 10.1007/s00296-011-1899-6. PMID: 21442167
Clinical and pathological characterization of patients with microscopic polyangiitis with medium artery involvement.
Zhao MH, Sun QZ, Wang HY
Ren Fail 2003 Nov;25(6):989-95. doi: 10.1081/jdi-120026034. PMID: 14669858

Clinical prediction guides

M2 macrophage infiltrates in the early stages of ANCA-associated pauci-immune necrotizing GN.
Zhao L, David MZ, Hyjek E, Chang A, Meehan SM
Clin J Am Soc Nephrol 2015 Jan 7;10(1):54-62. Epub 2014 Dec 16 doi: 10.2215/CJN.03230314. PMID: 25516918Free PMC Article
Characteristics and influence factors of pathologic transformation in the subclasses of class IV lupus nephritis.
Gao JJ, Cai GY, Liu SW, Tang L, Zhang XG, Yang Y, Chen P, Liu SX, Ji JY, Shi SZ, Yin Z, Chen XM
Rheumatol Int 2012 Jun;32(6):1751-9. Epub 2011 Mar 26 doi: 10.1007/s00296-011-1899-6. PMID: 21442167
Class IV-G and IV-S lupus nephritis in Chinese patients: a large cohort study from a single center.
Yu F, Tan Y, Wu LH, Zhu SN, Liu G, Zhao MH
Lupus 2009 Oct;18(12):1073-81. doi: 10.1177/0961203309106795. PMID: 19762381

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