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Abnormal circulating androstenedione concentration

MedGen UID:
1786162
•Concept ID:
C5539827
•
Finding
HPO: HP:0033811

Definition

Any deviation from the normal concentration of androstenedione in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating androstenedione concentration

Professional guidelines

PubMed

Prenatal diagnosis of congenital lipoid adrenal hyperplasia.
Saenger P, Klonari Z, Black SM, Compagnone N, Mellon SH, Fleischer A, Abrams CA, Shackelton CH, Miller WL
J Clin Endocrinol Metab 1995 Jan;80(1):200-5. doi: 10.1210/jcem.80.1.7829612. PMID: 7829612

Recent clinical studies

Etiology

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
The correlation between the concentration of hepcidin in serum and the occurrence of insulin resistance and hyperandrogenemia in women with polycystic ovary syndrome.
Pluta D, Franik G, Blukacz Ł, Kowalczyk K, Witkowska A, Wysocka M, Madej P
Eur Rev Med Pharmacol Sci 2018 Nov;22(21):7379-7384. doi: 10.26355/eurrev_201811_16276. PMID: 30468484
Evaluation of the correlation between insulin like factor 3, polycystic ovary syndrome, and ovarian maldescent.
Seyam E, Hefzy E
Gynecol Endocrinol 2018 Jun;34(6):481-488. Epub 2017 Dec 19 doi: 10.1080/09513590.2017.1416462. PMID: 29254383
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
17 beta-Oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals.
Pache TD, Hop WC, de Jong FH, Leerentveld RA, van Geldorp H, Van de Kamp TM, Gooren LJ, Fauser BC
Clin Endocrinol (Oxf) 1992 Jun;36(6):565-71. doi: 10.1111/j.1365-2265.1992.tb02266.x. PMID: 1424181

Diagnosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Evaluation of the correlation between insulin like factor 3, polycystic ovary syndrome, and ovarian maldescent.
Seyam E, Hefzy E
Gynecol Endocrinol 2018 Jun;34(6):481-488. Epub 2017 Dec 19 doi: 10.1080/09513590.2017.1416462. PMID: 29254383
Prenatal diagnosis of congenital lipoid adrenal hyperplasia.
Saenger P, Klonari Z, Black SM, Compagnone N, Mellon SH, Fleischer A, Abrams CA, Shackelton CH, Miller WL
J Clin Endocrinol Metab 1995 Jan;80(1):200-5. doi: 10.1210/jcem.80.1.7829612. PMID: 7829612
Long-term administration of gonadotropin-releasing hormone agonist and dexamethasone: assessment of the adrenal role in ovarian dysfunction.
Cedars MI, Steingold KA, de Ziegler D, Lapolt PS, Chang RJ, Judd HL
Fertil Steril 1992 Mar;57(3):495-500. doi: 10.1016/s0015-0282(16)54890-0. PMID: 1531463
Steroidogenesis in human polycystic ovary.
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567

Therapy

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide.
Ibáñez L, Potau N, Marcos MV, de Zegher F
J Clin Endocrinol Metab 2000 Sep;85(9):3251-5. doi: 10.1210/jcem.85.9.6814. PMID: 10999817
Long-term administration of gonadotropin-releasing hormone agonist and dexamethasone: assessment of the adrenal role in ovarian dysfunction.
Cedars MI, Steingold KA, de Ziegler D, Lapolt PS, Chang RJ, Judd HL
Fertil Steril 1992 Mar;57(3):495-500. doi: 10.1016/s0015-0282(16)54890-0. PMID: 1531463
17 beta-Oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals.
Pache TD, Hop WC, de Jong FH, Leerentveld RA, van Geldorp H, Van de Kamp TM, Gooren LJ, Fauser BC
Clin Endocrinol (Oxf) 1992 Jun;36(6):565-71. doi: 10.1111/j.1365-2265.1992.tb02266.x. PMID: 1424181

Prognosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Circulating hormones and breast cancer risk in premenopausal women: a randomized trial of low-dose tamoxifen and fenretinide.
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787

Clinical prediction guides

Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide.
Ibáñez L, Potau N, Marcos MV, de Zegher F
J Clin Endocrinol Metab 2000 Sep;85(9):3251-5. doi: 10.1210/jcem.85.9.6814. PMID: 10999817
Androgen response to hypothalamic-pituitary-adrenal stimulation with naloxone in women with myotonic muscular dystrophy.
Buyalos RP, Jackson RV, Grice GI, Hockings GI, Torpy DJ, Fox LM, Boots LR, Azziz R
J Clin Endocrinol Metab 1998 Sep;83(9):3219-24. doi: 10.1210/jcem.83.9.5078. PMID: 9745431
17 beta-Oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals.
Pache TD, Hop WC, de Jong FH, Leerentveld RA, van Geldorp H, Van de Kamp TM, Gooren LJ, Fauser BC
Clin Endocrinol (Oxf) 1992 Jun;36(6):565-71. doi: 10.1111/j.1365-2265.1992.tb02266.x. PMID: 1424181
Plasma androgens and oestradiol during oral glucose tolerance test in patients with polycystic ovaries.
Tiitinen A, Pekonen F, Stenman UH, Laatikainen T
Hum Reprod 1990 Apr;5(3):242-5. doi: 10.1093/oxfordjournals.humrep.a137080. PMID: 2191000
Steroidogenesis in human polycystic ovary.
Mahajan DK
Endocrinol Metab Clin North Am 1988 Dec;17(4):751-69. PMID: 3143567

Recent systematic reviews

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908

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