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Glomerular lipoprotein thrombus

MedGen UID:
1785875
•Concept ID:
C5539489
•
Finding
HPO: HP:0033294

Definition

Intracapillary silver-positive material that is finely vacuolated and laminated, and stains with oil red O on frozen sections. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular lipoprotein thrombus

Recent clinical studies

Etiology

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Retinal Vein Occlusion is Associated with Low Blood High-Density Lipoprotein Cholesterol: A Nationwide Cohort Study.
Kim J, Lim DH, Han K, Kang SW, Ham DI, Kim SJ, Chung TY
Am J Ophthalmol 2019 Sep;205:35-42. Epub 2019 Apr 6 doi: 10.1016/j.ajo.2019.04.001. PMID: 30959001
The Effects of 2'-O-Methoxyethyl Oligonucleotides on Renal Function in Humans.
Crooke ST, Baker BF, Pham NC, Hughes SG, Kwoh TJ, Cai D, Tsimikas S, Geary RS, Bhanot S
Nucleic Acid Ther 2018 Feb;28(1):10-22. Epub 2017 Nov 29 doi: 10.1089/nat.2017.0693. PMID: 29185862Free PMC Article
HMG CoA reductase inhibitors and renoprotection: the weight of the evidence.
Romayne Kurukulasuriya L, Athappan G, Saab G, Whaley Connell A, Sowers JR
Ther Adv Cardiovasc Dis 2007 Oct;1(1):49-59. doi: 10.1177/1753944707082714. PMID: 19124395
Omega-3 fatty acid supplementation and lipoprotein(a) concentrations in patients with chronic glomerular diseases.
Lenzi S, Caprioli R, Rindi P, Lazzerini G, Bernini W, Pardini E, Lucchetti A, Galli C, Carr L, De Caterina R
Nephron 1996;72(3):383-90. doi: 10.1159/000188900. PMID: 8852484

Diagnosis

Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy.
Qin Y, Sun XJ, Hu YF, Jing M, Yu XJ, Zhao MH, Tan Y
Ren Fail 2024 Dec;46(1):2332491. Epub 2024 Mar 26 doi: 10.1080/0886022X.2024.2332491. PMID: 38584145Free PMC Article
Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Lipoprotein glomerulopathy resulting from compound heterogeneous mutations of APOE gene: A case report.
Li Y, Chen J, Zou Y, Wang W, Li G
Medicine (Baltimore) 2022 Feb 4;101(5):e28718. doi: 10.1097/MD.0000000000028718. PMID: 35119017Free PMC Article
Retinal Vein Occlusion is Associated with Low Blood High-Density Lipoprotein Cholesterol: A Nationwide Cohort Study.
Kim J, Lim DH, Han K, Kang SW, Ham DI, Kim SJ, Chung TY
Am J Ophthalmol 2019 Sep;205:35-42. Epub 2019 Apr 6 doi: 10.1016/j.ajo.2019.04.001. PMID: 30959001
Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease.
Solak Y, Yilmaz MI, Siriopol D, Saglam M, Unal HU, Yaman H, Gok M, Cetinkaya H, Gaipov A, Eyileten T, Sari S, Yildirim AO, Tonbul HZ, Turk S, Covic A, Kanbay M
Int Urol Nephrol 2015 Dec;47(12):1993-2001. Epub 2015 Oct 26 doi: 10.1007/s11255-015-1136-4. PMID: 26498629

Therapy

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
The Effects of 2'-O-Methoxyethyl Oligonucleotides on Renal Function in Humans.
Crooke ST, Baker BF, Pham NC, Hughes SG, Kwoh TJ, Cai D, Tsimikas S, Geary RS, Bhanot S
Nucleic Acid Ther 2018 Feb;28(1):10-22. Epub 2017 Nov 29 doi: 10.1089/nat.2017.0693. PMID: 29185862Free PMC Article
HMG CoA reductase inhibitors and renoprotection: the weight of the evidence.
Romayne Kurukulasuriya L, Athappan G, Saab G, Whaley Connell A, Sowers JR
Ther Adv Cardiovasc Dis 2007 Oct;1(1):49-59. doi: 10.1177/1753944707082714. PMID: 19124395
Omega-3 fatty acid supplementation and lipoprotein(a) concentrations in patients with chronic glomerular diseases.
Lenzi S, Caprioli R, Rindi P, Lazzerini G, Bernini W, Pardini E, Lucchetti A, Galli C, Carr L, De Caterina R
Nephron 1996;72(3):383-90. doi: 10.1159/000188900. PMID: 8852484
Clinical pharmacokinetics of heparin.
Estes JW
Clin Pharmacokinet 1980 May-Jun;5(3):204-20. doi: 10.2165/00003088-198005030-00002. PMID: 6993082

Prognosis

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Retinal Vein Occlusion is Associated with Low Blood High-Density Lipoprotein Cholesterol: A Nationwide Cohort Study.
Kim J, Lim DH, Han K, Kang SW, Ham DI, Kim SJ, Chung TY
Am J Ophthalmol 2019 Sep;205:35-42. Epub 2019 Apr 6 doi: 10.1016/j.ajo.2019.04.001. PMID: 30959001
Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease.
Solak Y, Yilmaz MI, Siriopol D, Saglam M, Unal HU, Yaman H, Gok M, Cetinkaya H, Gaipov A, Eyileten T, Sari S, Yildirim AO, Tonbul HZ, Turk S, Covic A, Kanbay M
Int Urol Nephrol 2015 Dec;47(12):1993-2001. Epub 2015 Oct 26 doi: 10.1007/s11255-015-1136-4. PMID: 26498629
Risk and predictors of arterial thrombosis in lupus and non-lupus primary glomerulonephritis: a comparative study.
Mok CC, Tong KH, To CH, Siu YP, Ho LY, Au TC
Medicine (Baltimore) 2007 Jul;86(4):203-209. doi: 10.1097/md.0b013e318123f888. PMID: 17632261
Omega-3 fatty acid supplementation and lipoprotein(a) concentrations in patients with chronic glomerular diseases.
Lenzi S, Caprioli R, Rindi P, Lazzerini G, Bernini W, Pardini E, Lucchetti A, Galli C, Carr L, De Caterina R
Nephron 1996;72(3):383-90. doi: 10.1159/000188900. PMID: 8852484

Clinical prediction guides

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG
Eur Heart J 2022 Dec 7;43(46):4832-4844. doi: 10.1093/eurheartj/ehac444. PMID: 35943897
Retinal Vein Occlusion is Associated with Low Blood High-Density Lipoprotein Cholesterol: A Nationwide Cohort Study.
Kim J, Lim DH, Han K, Kang SW, Ham DI, Kim SJ, Chung TY
Am J Ophthalmol 2019 Sep;205:35-42. Epub 2019 Apr 6 doi: 10.1016/j.ajo.2019.04.001. PMID: 30959001
The Effects of 2'-O-Methoxyethyl Oligonucleotides on Renal Function in Humans.
Crooke ST, Baker BF, Pham NC, Hughes SG, Kwoh TJ, Cai D, Tsimikas S, Geary RS, Bhanot S
Nucleic Acid Ther 2018 Feb;28(1):10-22. Epub 2017 Nov 29 doi: 10.1089/nat.2017.0693. PMID: 29185862Free PMC Article
Serum neutrophil gelatinase-associated lipocalin is associated with cardiovascular events in patients with chronic kidney disease.
Solak Y, Yilmaz MI, Siriopol D, Saglam M, Unal HU, Yaman H, Gok M, Cetinkaya H, Gaipov A, Eyileten T, Sari S, Yildirim AO, Tonbul HZ, Turk S, Covic A, Kanbay M
Int Urol Nephrol 2015 Dec;47(12):1993-2001. Epub 2015 Oct 26 doi: 10.1007/s11255-015-1136-4. PMID: 26498629
Risk and predictors of arterial thrombosis in lupus and non-lupus primary glomerulonephritis: a comparative study.
Mok CC, Tong KH, To CH, Siu YP, Ho LY, Au TC
Medicine (Baltimore) 2007 Jul;86(4):203-209. doi: 10.1097/md.0b013e318123f888. PMID: 17632261

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