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Decreased RV/TLC ratio

MedGen UID:
1785836
•Concept ID:
C5539804
•
Finding
HPO: HP:0033773

Definition

An abnormally low ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining after maximal expiration and TLC is the total amount of air in the lungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased RV/TLC ratio

Recent clinical studies

Etiology

Impact of biologics on lung hyperinflation in patients with severe asthma.
Maniscalco M, Candia C, Calabrese C, D'Amato M, Matera MG, Molino A, Cazzola M
Respir Med 2024 Apr-May;225:107578. Epub 2024 Mar 1 doi: 10.1016/j.rmed.2024.107578. PMID: 38431058
Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation.
Lim JU, Park S, Yoon JH, Lee SE, Cho BS, Kim YJ, Lee S, Kim HJ, Rhee CK
Respir Med 2023 Nov;218:107410. Epub 2023 Sep 9 doi: 10.1016/j.rmed.2023.107410. PMID: 37696312
Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez FJ, Ozkan E, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC, Kesimer M
Lancet Respir Med 2021 Nov;9(11):1241-1254. Epub 2021 May 28 doi: 10.1016/S2213-2600(21)00079-5. PMID: 34058148Free PMC Article
Influence of Proprioceptive Neuromuscular Facilitation on Lung Function in Patients After Coronary Artery Bypass Graft Surgery.
Bujar-Misztal M, Chciałowski A
Adv Exp Med Biol 2018;1116:11-17. doi: 10.1007/5584_2018_243. PMID: 30128938
Concomitant changes in function tests, breathing pattern And PaCO2 in patients with chronic obstructive pulmonary disease.
Parot S, Saunier C, Schrijen F, Gautier H, Milic-Emili J
Bull Eur Physiopathol Respir 1982 Jan-Feb;18(1):145-51. PMID: 6797493

Diagnosis

Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation.
Lim JU, Park S, Yoon JH, Lee SE, Cho BS, Kim YJ, Lee S, Kim HJ, Rhee CK
Respir Med 2023 Nov;218:107410. Epub 2023 Sep 9 doi: 10.1016/j.rmed.2023.107410. PMID: 37696312
Understanding the Impact of Pulmonary Rehabilitation on Airway Resistance in Patients with Severe COPD: A Single-Center Retrospective Study.
Kiliç L, Tural Önür S, Gorek Dilektasli A, Ulubay G, Balcı A
Int J Chron Obstruct Pulmon Dis 2023;18:1-10. Epub 2023 Jan 4 doi: 10.2147/COPD.S384127. PMID: 36628301Free PMC Article
Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez FJ, Ozkan E, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC, Kesimer M
Lancet Respir Med 2021 Nov;9(11):1241-1254. Epub 2021 May 28 doi: 10.1016/S2213-2600(21)00079-5. PMID: 34058148Free PMC Article
Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.
Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group
Respir Med 2018 Aug;141:190-197. Epub 2018 Jun 27 doi: 10.1016/j.rmed.2018.06.022. PMID: 30053966
Severe pleural restriction: the maximum static pulmonary recoil pressure as an acid in diagnosis.
Colp C, Reichel J, Park SS
Chest 1975 Jun;67(6):658-64. doi: 10.1378/chest.67.6.658. PMID: 1126221

Therapy

Impact of biologics on lung hyperinflation in patients with severe asthma.
Maniscalco M, Candia C, Calabrese C, D'Amato M, Matera MG, Molino A, Cazzola M
Respir Med 2024 Apr-May;225:107578. Epub 2024 Mar 1 doi: 10.1016/j.rmed.2024.107578. PMID: 38431058
Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation.
Lim JU, Park S, Yoon JH, Lee SE, Cho BS, Kim YJ, Lee S, Kim HJ, Rhee CK
Respir Med 2023 Nov;218:107410. Epub 2023 Sep 9 doi: 10.1016/j.rmed.2023.107410. PMID: 37696312
Ventilation inhomogeneity and NO and CO diffusing capacity in ex-premature school children.
Sørensen JK, Buchvald F, Berg AK, Robinson PD, Nielsen KG
Respir Med 2018 Jul;140:94-100. Epub 2018 Jun 6 doi: 10.1016/j.rmed.2018.06.006. PMID: 29957288
Lung function parameters in omalizumab responder patients: An interesting tool?
Paganin F, Mangiapan G, Proust A, Prudhomme A, Attia J, Marchand-Adam S, Pellet F, Milhe F, Melloni B, Bernady A, Raspaud C, Nocent C, Berger P, Guilleminault L
Allergy 2017 Dec;72(12):1953-1961. Epub 2017 Jun 14 doi: 10.1111/all.13202. PMID: 28517027
Treatment of adult asthma: controlled double-blind clinical trial of oxitropium bromide.
Taytard A, Auzerie J, Vergeret J, Tozon N, Freour P
Eur J Clin Pharmacol 1984;26(4):429-33. doi: 10.1007/BF00542136. PMID: 6376144

Prognosis

Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation.
Lim JU, Park S, Yoon JH, Lee SE, Cho BS, Kim YJ, Lee S, Kim HJ, Rhee CK
Respir Med 2023 Nov;218:107410. Epub 2023 Sep 9 doi: 10.1016/j.rmed.2023.107410. PMID: 37696312
Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez FJ, Ozkan E, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC, Kesimer M
Lancet Respir Med 2021 Nov;9(11):1241-1254. Epub 2021 May 28 doi: 10.1016/S2213-2600(21)00079-5. PMID: 34058148Free PMC Article
Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.
Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group
Respir Med 2018 Aug;141:190-197. Epub 2018 Jun 27 doi: 10.1016/j.rmed.2018.06.022. PMID: 30053966
Ventilation inhomogeneity and NO and CO diffusing capacity in ex-premature school children.
Sørensen JK, Buchvald F, Berg AK, Robinson PD, Nielsen KG
Respir Med 2018 Jul;140:94-100. Epub 2018 Jun 6 doi: 10.1016/j.rmed.2018.06.006. PMID: 29957288
Concomitant changes in function tests, breathing pattern And PaCO2 in patients with chronic obstructive pulmonary disease.
Parot S, Saunier C, Schrijen F, Gautier H, Milic-Emili J
Bull Eur Physiopathol Respir 1982 Jan-Feb;18(1):145-51. PMID: 6797493

Clinical prediction guides

Impact of biologics on lung hyperinflation in patients with severe asthma.
Maniscalco M, Candia C, Calabrese C, D'Amato M, Matera MG, Molino A, Cazzola M
Respir Med 2024 Apr-May;225:107578. Epub 2024 Mar 1 doi: 10.1016/j.rmed.2024.107578. PMID: 38431058
Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation.
Lim JU, Park S, Yoon JH, Lee SE, Cho BS, Kim YJ, Lee S, Kim HJ, Rhee CK
Respir Med 2023 Nov;218:107410. Epub 2023 Sep 9 doi: 10.1016/j.rmed.2023.107410. PMID: 37696312
Changes in Pulmonary Functions of Adolescents with Pectus Excavatum Throughout the Nuss Procedure.
Dreher C, Reinsberg M, Oetzmann von Sochaczewski C, Siebert S, Strohm J, Kurz R, Ziegler AM, Heydweiller A, Yavuz ST
J Pediatr Surg 2023 Sep;58(9):1674-1678. Epub 2023 Feb 28 doi: 10.1016/j.jpedsurg.2023.02.057. PMID: 36935229
Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez FJ, Ozkan E, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC, Kesimer M
Lancet Respir Med 2021 Nov;9(11):1241-1254. Epub 2021 May 28 doi: 10.1016/S2213-2600(21)00079-5. PMID: 34058148Free PMC Article
Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.
Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group
Respir Med 2018 Aug;141:190-197. Epub 2018 Jun 27 doi: 10.1016/j.rmed.2018.06.022. PMID: 30053966

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