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Decreased maximal oxygen uptake

MedGen UID:
1785833
•Concept ID:
C5539798
•
Finding
HPO: HP:0033760

Definition

Maximum oxygen uptake (VO2max) is defined as the highest rate of oxygen uptake and utilization by the body during intense, maximal exercise, whereby further increases in work rate do not bring on additional rises in VO2 (i.e. plateau). VO2Max is typically measured with a treadmill anad ergometer and the participant exercises with increasing levels of intensity. VO2Max is the point at which oxygen uptake no longer increases despite an increase in workload. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased maximal oxygen uptake

Professional guidelines

PubMed

Longitudinal Changes in Skeletal Muscle Metabolism, Oxygen Uptake, and Myosteatosis During Cardiotoxic Treatment for Early-Stage Breast Cancer.
Kirkham AA, Pituskin E, Mackey JR, Grenier JG, Ian Paterson D, Haykowsky MJ, Thompson RB
Oncologist 2022 Sep 2;27(9):e748-e754. doi: 10.1093/oncolo/oyac092. PMID: 35579489Free PMC Article
Effects of chronic metformin treatment on training adaptations in men and women with hyperglycemia: A prospective study.
Moreno-Cabañas A, Morales-Palomo F, Alvarez-Jimenez L, Ortega JF, Mora-Rodriguez R
Obesity (Silver Spring) 2022 Jun;30(6):1219-1230. Epub 2022 May 17 doi: 10.1002/oby.23410. PMID: 35578807Free PMC Article
Lung function and exercise performance in hyperthyroidism before and after treatment.
Kendrick AH, O'Reilly JF, Laszlo G
Q J Med 1988 Aug;68(256):615-27. PMID: 3255983

Recent clinical studies

Etiology

Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans.
Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW
Appl Physiol Nutr Metab 2019 Sep;44(9):958-964. Epub 2019 Jan 21 doi: 10.1139/apnm-2018-0577. PMID: 30664360
Effects of polluted air on cardiovascular and hematological parameters after progressive maximal aerobic exercise.
Kargarfard M, Shariat A, Shaw BS, Shaw I, Lam ET, Kheiri A, Eatemadyboroujeni A, Tamrin SB
Lung 2015 Apr;193(2):275-81. Epub 2015 Jan 22 doi: 10.1007/s00408-014-9679-1. PMID: 25604940

Diagnosis

Cardiovascular function following reduced aerobic activity.
Raven PB, Welch-O'Connor RM, Shi X
Med Sci Sports Exerc 1998 Jul;30(7):1041-52. doi: 10.1097/00005768-199807000-00004. PMID: 9662671

Therapy

Effects of polluted air on cardiovascular and hematological parameters after progressive maximal aerobic exercise.
Kargarfard M, Shariat A, Shaw BS, Shaw I, Lam ET, Kheiri A, Eatemadyboroujeni A, Tamrin SB
Lung 2015 Apr;193(2):275-81. Epub 2015 Jan 22 doi: 10.1007/s00408-014-9679-1. PMID: 25604940
Cardiovascular drift during heat stress: implications for exercise prescription.
Wingo JE, Ganio MS, Cureton KJ
Exerc Sport Sci Rev 2012 Apr;40(2):88-94. doi: 10.1097/JES.0b013e31824c43af. PMID: 22410803
Body cooling attenuates the decrease in maximal oxygen uptake associated with cardiovascular drift during heat stress.
Wingo JE, Cureton KJ
Eur J Appl Physiol 2006 Sep;98(1):97-104. Epub 2006 Jul 29 doi: 10.1007/s00421-006-0249-y. PMID: 16896737

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