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Diffusely thickened glomerular basement membrane

MedGen UID:
1783796
•Concept ID:
C5539480
•
Finding
HPO: HP:0033284

Definition

Prominent glomerular basement membrane (GBM) reflecting an diffuse and relatively uniform increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffusely thickened glomerular basement membrane

Recent clinical studies

Etiology

Clinical and pathological features of dense deposit disease in Chinese patients.
Wang J, Tang Z, Luo C, Hu Y, Zeng C, Chen H, Liu Z
Clin Nephrol 2012 Sep;78(3):207-15. doi: 10.5414/cn107363. PMID: 22874109
Idiopathic nodular glomerulosclerosis: three Japanese cases and review of the literature.
Kusaba T, Hatta T, Sonomura K, Mori Y, Tokoro T, Nagata T, Umeda Y, Nagata K, Yasuda T, Sato T, Kimura K, Matsubara H
Clin Nephrol 2007 Jan;67(1):32-7. doi: 10.5414/cnp67032. PMID: 17269597
Isolate diffuse thickening of glomerular capillary basement membrane: a renal lesion in prediabetes?
Mac-Moune Lai F, Szeto CC, Choi PC, Ho KK, Tang NL, Chow KM, Li PK, To KF
Mod Pathol 2004 Dec;17(12):1506-12. doi: 10.1038/modpathol.3800219. PMID: 15254555
Renal disease in hepatosplenic schistosomiasis: a clinicopathological study.
Barsoum RS, Bassily S, Baligh OK, Eissa M, El-Sheemy N, Affify N, Hassaballa AM
Trans R Soc Trop Med Hyg 1977;71(5):387-91. doi: 10.1016/0035-9203(77)90035-9. PMID: 595092
Clinical, light, and electron microscopy findings in idiopathic haematuria.
Alexander F, Lannigan R, Bull R
J Clin Pathol 1973 Oct;26(10):750-9. doi: 10.1136/jcp.26.10.750. PMID: 4750456Free PMC Article

Diagnosis

Lupus podocytopathy superimposed on diabetic glomerulosclerosis: A case report.
Liu L, Murray B, Tomaszewski JE
Medicine (Baltimore) 2021 Sep 17;100(37):e27077. doi: 10.1097/MD.0000000000027077. PMID: 34664831Free PMC Article
Potential relationship between eGFR(cystatin C) /eGFR(creatinine) -ratio and glomerular basement membrane thickness in diabetic kidney disease.
Öberg CM, Lindström M, Grubb A, Christensson A
Physiol Rep 2021 Jul;9(13):e14939. doi: 10.14814/phy2.14939. PMID: 34254743Free PMC Article
Concomitant Nephrotic Syndrome with Diffuse Large B-cell Lymphoma: A Case Report.
Kidoguchi K, Katsuya H, Ureshino H, Kizuka-Sano H, Yamaguchi K, Nagata A, Rikitake S, Aikawa K, Naito S, Aoki S, Kubota Y, Ando T, Kimura S
Tohoku J Exp Med 2020 Oct;252(2):153-157. doi: 10.1620/tjem.252.153. PMID: 33028760
Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.
Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103
Diabetic glomerulosclerosis without glucose intolerance.
Nash DA Jr, Rogers PW, Langlinais PC, Bunn SM Jr
Am J Med 1975 Aug;59(2):191-9. doi: 10.1016/0002-9343(75)90353-8. PMID: 1155478

Therapy

Hilar lymphadenopathy, development of tubulointerstitial nephritis, and dense deposit disease following Pfizer-BioNTech COVID-19 vaccination.
Nakamura H, Ueda M, Anayama M, Makino M, Makino Y
CEN Case Rep 2023 Aug;12(3):287-291. Epub 2022 Dec 13 doi: 10.1007/s13730-022-00762-7. PMID: 36513952Free PMC Article
Lupus podocytopathy superimposed on diabetic glomerulosclerosis: A case report.
Liu L, Murray B, Tomaszewski JE
Medicine (Baltimore) 2021 Sep 17;100(37):e27077. doi: 10.1097/MD.0000000000027077. PMID: 34664831Free PMC Article
Renal injury following long-term exposure to carbon disulfide: analysis of a case series.
Yan Y, Wang C, Zheng Z, Qu L, Zeng D, Li M
BMC Nephrol 2019 Oct 17;20(1):377. doi: 10.1186/s12882-019-1553-1. PMID: 31623563Free PMC Article
Clinical and pathological features of dense deposit disease in Chinese patients.
Wang J, Tang Z, Luo C, Hu Y, Zeng C, Chen H, Liu Z
Clin Nephrol 2012 Sep;78(3):207-15. doi: 10.5414/cn107363. PMID: 22874109
Cryoglobulinemic glomerulonephritis: a membranoproliferative glomerulonephritis induced by hepatitis C virus.
D'Amico G, Fornasieri A
Am J Kidney Dis 1995 Mar;25(3):361-9. doi: 10.1016/0272-6386(95)90095-0. PMID: 7532915

Prognosis

Potential relationship between eGFR(cystatin C) /eGFR(creatinine) -ratio and glomerular basement membrane thickness in diabetic kidney disease.
Öberg CM, Lindström M, Grubb A, Christensson A
Physiol Rep 2021 Jul;9(13):e14939. doi: 10.14814/phy2.14939. PMID: 34254743Free PMC Article
Clinical and pathological analyses of transplant glomerulopathy cases.
Shimizu T, Ishida H, Toki D, Nozaki T, Omoto K, Tanabe K, Honda K, Koike J
Nephrology (Carlton) 2014 Jun;19 Suppl 3:21-6. doi: 10.1111/nep.12243. PMID: 24842817
Clinical and pathological features of dense deposit disease in Chinese patients.
Wang J, Tang Z, Luo C, Hu Y, Zeng C, Chen H, Liu Z
Clin Nephrol 2012 Sep;78(3):207-15. doi: 10.5414/cn107363. PMID: 22874109
Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.
Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103
Morphologic and clinical correlates in renal amyloidosis.
Dikman SH, Churg J, Kahn T
Hum Pathol 1981 Feb;12(2):160-9. doi: 10.1016/s0046-8177(81)80103-7. PMID: 7216218

Clinical prediction guides

Potential relationship between eGFR(cystatin C) /eGFR(creatinine) -ratio and glomerular basement membrane thickness in diabetic kidney disease.
Öberg CM, Lindström M, Grubb A, Christensson A
Physiol Rep 2021 Jul;9(13):e14939. doi: 10.14814/phy2.14939. PMID: 34254743Free PMC Article
Renal injury following long-term exposure to carbon disulfide: analysis of a case series.
Yan Y, Wang C, Zheng Z, Qu L, Zeng D, Li M
BMC Nephrol 2019 Oct 17;20(1):377. doi: 10.1186/s12882-019-1553-1. PMID: 31623563Free PMC Article
Spectrum of collagen type IV nephropathies: from thin basement membrane nephropathy to Alport syndrome.
Vizjak A, Ferluga D
Srp Arh Celok Lek 2008 Dec;136 Suppl 4:323-6. doi: 10.2298/sarh08s4323v. PMID: 20804103
SEM studies of acellular glomerular basement membrane in human diabetic glomerulopathy.
Carlson EC, Surerus KK
Anat Rec 1986 Nov;216(3):349-58. doi: 10.1002/ar.1092160303. PMID: 3789417
Clinical, light, and electron microscopy findings in idiopathic haematuria.
Alexander F, Lannigan R, Bull R
J Clin Pathol 1973 Oct;26(10):750-9. doi: 10.1136/jcp.26.10.750. PMID: 4750456Free PMC Article

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