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Glomerular parietal epithelial cell hyperplasia

MedGen UID:
1782516
•Concept ID:
C5539433
•
Finding
Synonym: Hyperplasia of the glomerular parietal epithelial cell
 
HPO: HP:0033224

Definition

Increased number of parietal epithelial cells lining Bowman's capsule. Hyperplasia leads to the cells being present in 2 or more layers, often with crowding and multilayering. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular parietal epithelial cell hyperplasia

Recent clinical studies

Etiology

Role of progenitor cell marker CD133 in supporting diagnosis of collapsing glomerulopathy.
Xiao AY, Kanaan HD, Lai Z, Li W, Zhang PL
Int Urol Nephrol 2022 Aug;54(8):1957-1968. Epub 2022 Jan 3 doi: 10.1007/s11255-021-03078-0. PMID: 34978023Free PMC Article
Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis.
Miesen L, Eymael J, Sharma S, Loeven MA, Willemsen B, Bakker-van Bebber M, Mooren F, Meyer-Schwesinger C, Dijkman H, Wetzels JFM, Jansen J, van der Vlag J, Smeets B
Sci Rep 2020 May 22;10(1):8580. doi: 10.1038/s41598-020-65352-y. PMID: 32444668Free PMC Article
Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.
Zeng Y, Wang X, Xie F, Zheng Z
Pathol Res Pract 2017 Aug;213(8):982-986. Epub 2017 Apr 20 doi: 10.1016/j.prp.2017.04.006. PMID: 28595914
Pathobiology of focal segmental glomerulosclerosis: new developments.
D'Agati VD
Curr Opin Nephrol Hypertens 2012 May;21(3):243-50. doi: 10.1097/MNH.0b013e32835200df. PMID: 22357339
PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study.
Ozcan A, Shen SS, Hamilton C, Anjana K, Coffey D, Krishnan B, Truong LD
Mod Pathol 2011 Jun;24(6):751-64. Epub 2011 Feb 11 doi: 10.1038/modpathol.2011.3. PMID: 21317881

Diagnosis

Role of progenitor cell marker CD133 in supporting diagnosis of collapsing glomerulopathy.
Xiao AY, Kanaan HD, Lai Z, Li W, Zhang PL
Int Urol Nephrol 2022 Aug;54(8):1957-1968. Epub 2022 Jan 3 doi: 10.1007/s11255-021-03078-0. PMID: 34978023Free PMC Article
Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.
Zeng Y, Wang X, Xie F, Zheng Z
Pathol Res Pract 2017 Aug;213(8):982-986. Epub 2017 Apr 20 doi: 10.1016/j.prp.2017.04.006. PMID: 28595914
Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly increased urinary podocyte excretion.
Ikezumi Y, Suzuki T, Karasawa T, Kaneko U, Yamada T, Hasegawa H, Nagata M, Saitoh A
Hum Pathol 2014 Aug;45(8):1778-83. Epub 2014 Apr 18 doi: 10.1016/j.humpath.2014.03.017. PMID: 24856573
PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study.
Ozcan A, Shen SS, Hamilton C, Anjana K, Coffey D, Krishnan B, Truong LD
Mod Pathol 2011 Jun;24(6):751-64. Epub 2011 Feb 11 doi: 10.1038/modpathol.2011.3. PMID: 21317881
Origin of hyperplastic epithelial cells in idiopathic collapsing glomerulopathy.
Kihara I, Yaoita E, Kawasaki K, Yamamoto T, Hara M, Yanagihara T
Histopathology 1999 Jun;34(6):537-47. doi: 10.1111/j.1365-2559.1999.00670.x. PMID: 10383699

Therapy

Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice.
Melica ME, Antonelli G, Semeraro R, Angelotti ML, Lugli G, Landini S, Ravaglia F, Regina G, Conte C, De Chiara L, Peired AJ, Mazzinghi B, Donati M, Molli A, Steiger S, Magi A, Bartalucci N, Raglianti V, Guzzi F, Maggi L, Annunziato F, Burger A, Lazzeri E, Anders HJ, Lasagni L, Romagnani P
Sci Transl Med 2022 Aug 10;14(657):eabg3277. doi: 10.1126/scitranslmed.abg3277. PMID: 35947676Free PMC Article
Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells.
Dijkman HB, Weening JJ, Smeets B, Verrijp KC, van Kuppevelt TH, Assmann KK, Steenbergen EJ, Wetzels JF
Kidney Int 2006 Jul;70(2):338-44. Epub 2006 Jun 7 doi: 10.1038/sj.ki.5001574. PMID: 16761013

Clinical prediction guides

Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis.
Miesen L, Eymael J, Sharma S, Loeven MA, Willemsen B, Bakker-van Bebber M, Mooren F, Meyer-Schwesinger C, Dijkman H, Wetzels JFM, Jansen J, van der Vlag J, Smeets B
Sci Rep 2020 May 22;10(1):8580. doi: 10.1038/s41598-020-65352-y. PMID: 32444668Free PMC Article
Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation.
Estrada CC, Paladugu P, Guo Y, Pace J, Revelo MP, Salant DJ, Shankland SJ, D'Agati VD, Mehrotra A, Cardona S, Bialkowska AB, Yang VW, He JC, Mallipattu SK
JCI Insight 2018 Jun 21;3(12) doi: 10.1172/jci.insight.98214. PMID: 29925693Free PMC Article
Ischemia-induced glomerular parietal epithelial cells hyperplasia: Commonly misdiagnosed cellular crescent in renal biopsy.
Zeng Y, Wang X, Xie F, Zheng Z
Pathol Res Pract 2017 Aug;213(8):982-986. Epub 2017 Apr 20 doi: 10.1016/j.prp.2017.04.006. PMID: 28595914
The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis.
Dijkman H, Smeets B, van der Laak J, Steenbergen E, Wetzels J
Kidney Int 2005 Oct;68(4):1562-72. doi: 10.1111/j.1523-1755.2005.00568.x. PMID: 16164633
Origin of hyperplastic epithelial cells in idiopathic collapsing glomerulopathy.
Kihara I, Yaoita E, Kawasaki K, Yamamoto T, Hara M, Yanagihara T
Histopathology 1999 Jun;34(6):537-47. doi: 10.1111/j.1365-2559.1999.00670.x. PMID: 10383699

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