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Glomerular obsolescence

MedGen UID:
1782435
•Concept ID:
C5539514
•
Finding
HPO: HP:0033321

Definition

Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular obsolescence

Professional guidelines

PubMed

Renal function and biopsy findings after 5 years' treatment with low-dose cyclosporin for psoriasis.
Powles AV, Cook T, Hulme B, Baker BS, Lewis HM, Thomas E, Valdimarsson H, Fry L
Br J Dermatol 1993 Feb;128(2):159-65. doi: 10.1111/j.1365-2133.1993.tb15145.x. PMID: 8457449

Recent clinical studies

Etiology

Urinary Vacuolar Casts Are a Unique Type of Casts in Advanced Proteinuric Glomerulopathies.
Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639Free PMC Article
Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy.
Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071Free PMC Article
A Single Center Experience With Adult Dual Kidney Transplant.
Olakkengil SA, Varatharajah K, Rao MM, Gulyani A, Hamilton M, Russ G, Russell C
Exp Clin Transplant 2015 Oct;13(5):408-12. PMID: 26450464
Renal vascular lesions in the elderly: nephrosclerosis or atheromatous renal disease?
Meyrier A
Nephrol Dial Transplant 1996;11 Suppl 9:45-52. doi: 10.1093/ndt/11.supp9.45. PMID: 9050035

Diagnosis

Urinary Vacuolar Casts Are a Unique Type of Casts in Advanced Proteinuric Glomerulopathies.
Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639Free PMC Article
Role of Palatine Tonsil and Epipharyngeal Lymphoid Tissue in the Development of Glomerular Active Lesions (Glomerular vasculitis) in Immunoglobulin A Nephropathy.
Hotta O, Ieiri N, Nagai M, Tanaka A, Harabuchi Y
Int J Mol Sci 2022 Jan 10;23(2) doi: 10.3390/ijms23020727. PMID: 35054911Free PMC Article
Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases.
He HG, Wu CQ, Ye K, Zeng C, Huang YY, Luo SW, Yin W, Ye QR, Peng XM
BMC Nephrol 2019 Aug 22;20(1):328. doi: 10.1186/s12882-019-1498-4. PMID: 31438882Free PMC Article
Renal biopsy in patients over 75: 131 cases.
Rollino C, Ferro M, Beltrame G, Quattrocchio G, Massara C, Quarello F, Roccatello D
Clin Nephrol 2014 Oct;82(4):225-30. doi: 10.5414/CN108258. PMID: 25161113Free PMC Article

Therapy

A Single Center Experience With Adult Dual Kidney Transplant.
Olakkengil SA, Varatharajah K, Rao MM, Gulyani A, Hamilton M, Russ G, Russell C
Exp Clin Transplant 2015 Oct;13(5):408-12. PMID: 26450464
Renal biopsy in patients over 75: 131 cases.
Rollino C, Ferro M, Beltrame G, Quattrocchio G, Massara C, Quarello F, Roccatello D
Clin Nephrol 2014 Oct;82(4):225-30. doi: 10.5414/CN108258. PMID: 25161113Free PMC Article
Predictors of poor outcomes in steroid therapy for immunoglobulin A nephropathy.
Shimizu A, Takei T, Uchida K, Tsuchiya K, Nitta K
Nephrology (Carlton) 2009 Aug;14(5):521-6. doi: 10.1111/j.1440-1797.2009.01104.x. PMID: 19674320
A clinicopathological study of IgA nephropathy in renal transplant recipients: beneficial effect of angiotensin-converting enzyme inhibitor.
Oka K, Imai E, Moriyama T, Akagi Y, Ando A, Hori M, Okuyama A, Toki K, Kyo M, Kokado Y, Takahara S
Nephrol Dial Transplant 2000 May;15(5):689-95. doi: 10.1093/ndt/15.5.689. PMID: 10809812
Cyclosporine-induced renal dysfunction in experimental animals and humans.
Remuzzi G, Perico N
Kidney Int Suppl 1995 Dec;52:S70-4. PMID: 8587288

Prognosis

Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy.
Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071Free PMC Article
Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases.
He HG, Wu CQ, Ye K, Zeng C, Huang YY, Luo SW, Yin W, Ye QR, Peng XM
BMC Nephrol 2019 Aug 22;20(1):328. doi: 10.1186/s12882-019-1498-4. PMID: 31438882Free PMC Article
Renal biopsy in patients over 75: 131 cases.
Rollino C, Ferro M, Beltrame G, Quattrocchio G, Massara C, Quarello F, Roccatello D
Clin Nephrol 2014 Oct;82(4):225-30. doi: 10.5414/CN108258. PMID: 25161113Free PMC Article
Ischemic renal diseases: new insights into old entities.
Meyrier A, Hill GS, Simon P
Kidney Int 1998 Jul;54(1):2-13. doi: 10.1046/j.1523-1755.1998.00968.x. PMID: 9648058

Clinical prediction guides

Urinary Vacuolar Casts Are a Unique Type of Casts in Advanced Proteinuric Glomerulopathies.
Rosenbloom S, Ramanand A, Stark A, Varghese V, Chalmers D, Au-Yeung N, Kanduri SR, Lukitsch I, Poloni JAT, Keitel E, Franz AP, Martínez-Figueroa C, Sarkar A, Alix-Arbatin MC, Fogo AB, Buchkremer F, Seltzer JR, Velez JCQ
Kidney360 2024 Feb 1;5(2):216-227. Epub 2024 Jan 19 doi: 10.34067/KID.0000000000000346. PMID: 38240639Free PMC Article
Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.
Eadon MT, Schwantes-An TH, Phillips CL, Roberts AR, Greene CV, Hallab A, Hart KJ, Lipp SN, Perez-Ledezma C, Omar KO, Kelly KJ, Moe SM, Dagher PC, El-Achkar TM, Moorthi RN
Am J Kidney Dis 2020 Sep;76(3):350-360. Epub 2020 Apr 24 doi: 10.1053/j.ajkd.2019.12.014. PMID: 32336487Free PMC Article
Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy.
Inoue T, Luo Y, Seto T, Suzuki H, Okada H
Ren Fail 2019 Nov;41(1):893-898. doi: 10.1080/0886022X.2019.1665545. PMID: 31557071Free PMC Article
A clinical predictor index for renal survival.
Araújo NC, Rioja Lda S, Rebelo MA
J Bras Nefrol 2010 Mar;32(1):27-32. PMID: 21448516
Ischemic renal diseases: new insights into old entities.
Meyrier A, Hill GS, Simon P
Kidney Int 1998 Jul;54(1):2-13. doi: 10.1046/j.1523-1755.1998.00968.x. PMID: 9648058

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