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Chronic Limb-Threatening Ischemia

MedGen UID:
1782264
Concept ID:
C1142264
Disease or Syndrome
Synonyms: Chronic Limb Threatening Ischemia; Critical Limb Ischemia; Ischemia, Chronic Limb-Threatening; Ischemia, Critical Limb; Limb Ischemia, Critical; Limb-Threatening Ischemia, Chronic

Definition

A severe form of peripheral artery disease in which a hypoperfusion of the BLOOD through an organ or tissue is caused by occlusion of peripheral arterial vessels. It is associated with the presence of chronic ischemic rest pain, ulceration or GANGRENE. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Limb-Threatening Ischemia

Professional guidelines

PubMed

Feldman ZM, Mohapatra A
Semin Vasc Surg 2022 Jun;35(2):190-199. Epub 2022 Apr 21 doi: 10.1053/j.semvascsurg.2022.04.008. PMID: 35672109
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH, Aboyans V, Aksoy M, Alexandrescu VA, Armstrong D, Azuma N, Belch J, Bergoeing M, Bjorck M, Chakfé N, Cheng S, Dawson J, Debus ES, Dueck A, Duval S, Eckstein HH, Ferraresi R, Gambhir R, Gargiulo M, Geraghty P, Goode S, Gray B, Guo W, Gupta PC, Hinchliffe R, Jetty P, Komori K, Lavery L, Liang W, Lookstein R, Menard M, Misra S, Miyata T, Moneta G, Munoa Prado JA, Munoz A, Paolini JE, Patel M, Pomposelli F, Powell R, Robless P, Rogers L, Schanzer A, Schneider P, Taylor S, De Ceniga MV, Veller M, Vermassen F, Wang J, Wang S; GVG Writing Group for the Joint Guidelines of the Society for Vascular Surgery (SVS), European Society for Vascular Surgery (ESVS), and World Federation of Vascular Societies (WFVS)
Eur J Vasc Endovasc Surg 2019 Jul;58(1S):S1-S109.e33. Epub 2019 Jun 8 doi: 10.1016/j.ejvs.2019.05.006. PMID: 31182334Free PMC Article
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article

Recent clinical studies

Etiology

Akingba AG, Chow WB, Rowe VL
Surg Clin North Am 2023 Aug;103(4):767-778. Epub 2023 May 21 doi: 10.1016/j.suc.2023.04.014. PMID: 37455036
Paisley MJ, Adkar S, Sheehan BM, Stern JR
Semin Vasc Surg 2022 Jun;35(2):162-171. Epub 2022 Apr 20 doi: 10.1053/j.semvascsurg.2022.04.005. PMID: 35672106
Aday AW, Matsushita K
Circ Res 2021 Jun 11;128(12):1818-1832. Epub 2021 Jun 10 doi: 10.1161/CIRCRESAHA.121.318535. PMID: 34110907Free PMC Article
Armstrong EJ, Armstrong DG
Vasc Med 2021 Apr;26(2):228-231. Epub 2021 Feb 15 doi: 10.1177/1358863X20987611. PMID: 33587691
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article

Diagnosis

McGinigle KL
Prim Care 2024 Mar;51(1):83-93. Epub 2023 Aug 30 doi: 10.1016/j.pop.2023.07.005. PMID: 38278575
Akingba AG, Chow WB, Rowe VL
Surg Clin North Am 2023 Aug;103(4):767-778. Epub 2023 May 21 doi: 10.1016/j.suc.2023.04.014. PMID: 37455036
Aday AW, Matsushita K
Circ Res 2021 Jun 11;128(12):1818-1832. Epub 2021 Jun 10 doi: 10.1161/CIRCRESAHA.121.318535. PMID: 34110907Free PMC Article
Armstrong EJ
Vasc Med 2021 Apr;26(2):121-122. doi: 10.1177/1358863X211000425. PMID: 33825576
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article

Therapy

Farber A, Menard MT, Conte MS, Kaufman JA, Powell RJ, Choudhry NK, Hamza TH, Assmann SF, Creager MA, Cziraky MJ, Dake MD, Jaff MR, Reid D, Siami FS, Sopko G, White CJ, van Over M, Strong MB, Villarreal MF, McKean M, Azene E, Azarbal A, Barleben A, Chew DK, Clavijo LC, Douville Y, Findeiss L, Garg N, Gasper W, Giles KA, Goodney PP, Hawkins BM, Herman CR, Kalish JA, Koopmann MC, Laskowski IA, Mena-Hurtado C, Motaganahalli R, Rowe VL, Schanzer A, Schneider PA, Siracuse JJ, Venermo M, Rosenfield K; BEST-CLI Investigators
N Engl J Med 2022 Dec 22;387(25):2305-2316. Epub 2022 Nov 7 doi: 10.1056/NEJMoa2207899. PMID: 36342173
Bonaca MP, Hamburg NM, Creager MA
Circ Res 2021 Jun 11;128(12):1868-1884. Epub 2021 Jun 10 doi: 10.1161/CIRCRESAHA.121.318258. PMID: 34110910
Aday AW, Matsushita K
Circ Res 2021 Jun 11;128(12):1818-1832. Epub 2021 Jun 10 doi: 10.1161/CIRCRESAHA.121.318535. PMID: 34110907Free PMC Article
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH, Aboyans V, Aksoy M, Alexandrescu VA, Armstrong D, Azuma N, Belch J, Bergoeing M, Bjorck M, Chakfé N, Cheng S, Dawson J, Debus ES, Dueck A, Duval S, Eckstein HH, Ferraresi R, Gambhir R, Gargiulo M, Geraghty P, Goode S, Gray B, Guo W, Gupta PC, Hinchliffe R, Jetty P, Komori K, Lavery L, Liang W, Lookstein R, Menard M, Misra S, Miyata T, Moneta G, Munoa Prado JA, Munoz A, Paolini JE, Patel M, Pomposelli F, Powell R, Robless P, Rogers L, Schanzer A, Schneider P, Taylor S, De Ceniga MV, Veller M, Vermassen F, Wang J, Wang S; GVG Writing Group for the Joint Guidelines of the Society for Vascular Surgery (SVS), European Society for Vascular Surgery (ESVS), and World Federation of Vascular Societies (WFVS)
Eur J Vasc Endovasc Surg 2019 Jul;58(1S):S1-S109.e33. Epub 2019 Jun 8 doi: 10.1016/j.ejvs.2019.05.006. PMID: 31182334Free PMC Article
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article

Prognosis

Lanzer P, Hannan FM, Lanzer JD, Janzen J, Raggi P, Furniss D, Schuchardt M, Thakker R, Fok PW, Saez-Rodriguez J, Millan A, Sato Y, Ferraresi R, Virmani R, St Hilaire C
J Am Coll Cardiol 2021 Sep 14;78(11):1145-1165. doi: 10.1016/j.jacc.2021.06.049. PMID: 34503684Free PMC Article
Aday AW, Matsushita K
Circ Res 2021 Jun 11;128(12):1818-1832. Epub 2021 Jun 10 doi: 10.1161/CIRCRESAHA.121.318535. PMID: 34110907Free PMC Article
Ganta VC, Annex BH
Expert Opin Ther Targets 2021 May;25(5):381-391. Epub 2021 Jun 17 doi: 10.1080/14728222.2021.1940139. PMID: 34098826Free PMC Article
Williams ZF, Gilmore B, Weissler H, Long C, Southerland K, Cox MW
Ann Vasc Surg 2021 Jul;74:511-514. Epub 2021 Apr 2 doi: 10.1016/j.avsg.2021.02.019. PMID: 33819588
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article

Clinical prediction guides

Varcoe RL, DeRubertis BG, Kolluri R, Krishnan P, Metzger DC, Bonaca MP, Shishehbor MH, Holden AH, Bajakian DR, Garcia LA, Kum SWC, Rundback J, Armstrong E, Lee JK, Khatib Y, Weinberg I, Garcia-Garcia HM, Ruster K, Teraphongphom NT, Zheng Y, Wang J, Jones-McMeans JM, Parikh SA; LIFE-BTK Investigators
N Engl J Med 2024 Jan 4;390(1):9-19. Epub 2023 Oct 25 doi: 10.1056/NEJMoa2305637. PMID: 37888915
Ganta VC, Annex BH
Expert Opin Ther Targets 2021 May;25(5):381-391. Epub 2021 Jun 17 doi: 10.1080/14728222.2021.1940139. PMID: 34098826Free PMC Article
Polonsky TS, McDermott MM
JAMA 2021 Jun 1;325(21):2188-2198. doi: 10.1001/jama.2021.2126. PMID: 34061140
Williams ZF, Gilmore B, Weissler H, Long C, Southerland K, Cox MW
Ann Vasc Surg 2021 Jul;74:511-514. Epub 2021 Apr 2 doi: 10.1016/j.avsg.2021.02.019. PMID: 33819588
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article

Recent systematic reviews

Tsukagoshi J, Shimoda T, Yokoyama Y, Secemsky EA, Shirasu T, Nakama T, Jujo K, Wiley J, Takagi H, Aikawa T, Kuno T
J Vasc Surg 2024 Apr;79(4):963-972.e11. Epub 2023 Sep 9 doi: 10.1016/j.jvs.2023.08.128. PMID: 37678642
Shan LL, Yang LS, Tew M, Westcott MJ, Spelman TD, Choong PF, Davies AH
Eur J Vasc Endovasc Surg 2022 Dec;64(6):666-683. Epub 2022 Aug 8 doi: 10.1016/j.ejvs.2022.07.051. PMID: 35952907
Shan LL, Wang J, Westcott MJ, Tew M, Davies AH, Choong PF
Ann Vasc Surg 2022 Sep;85:9-21. Epub 2022 May 11 doi: 10.1016/j.avsg.2022.04.036. PMID: 35561892
Matsuoka EK, Hasebe T, Ishii R, Miyazaki N, Soejima K, Iwasaki K
Cardiovasc Interv Ther 2022 Jan;37(1):145-157. Epub 2021 Feb 6 doi: 10.1007/s12928-021-00758-7. PMID: 33547627Free PMC Article
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article

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