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Elevated circulating acetoacetic acid concentration

MedGen UID:
1781355
•Concept ID:
C5539569
•
Finding
HPO: HP:0033408

Definition

An increased level of acetoacetic acid in the blood circulation. Acetoacetic acid is one of the predominant ketone bodies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating acetoacetic acid concentration

Recent clinical studies

Etiology

Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.
Kanikarla-Marie P, Jain SK
Free Radic Biol Med 2016 Jun;95:268-77. Epub 2016 Mar 29 doi: 10.1016/j.freeradbiomed.2016.03.020. PMID: 27036365Free PMC Article
Changes of the plasma ketone body level and arterial ketone body ratio at the onset of mild aneurysmal subarachnoid hemorrhage.
Tamaki T, Node Y, Teramoto A
Neurol Res 2008 Nov;30(9):898-902. Epub 2008 Aug 7 doi: 10.1179/016164108X323708. PMID: 18691448
Gut and liver coordinated metabolic response following major torso injury.
Poggetti RS, Moore EE, Moore FA, Bensard DD, Parsons P, Anderson BO, Banerjee A
J Surg Res 1992 Jan;52(1):27-33. doi: 10.1016/0022-4804(92)90274-4. PMID: 1548864
Metabolic control of kidney hemodynamics in normal and insulin-dependent diabetic subjects. Effects of acetoacetic, lactic, and acetic acids.
Trevisan R, Nosadini R, Fioretto P, Velussi M, Avogaro A, Duner E, Iori E, Doria A, Merkel C, Valerio A
Diabetes 1987 Sep;36(9):1073-81. doi: 10.2337/diab.36.9.1073. PMID: 3609498

Therapy

On the mammalian acetone metabolism: from chemistry to clinical implications.
Kalapos MP
Biochim Biophys Acta 2003 May 2;1621(2):122-39. doi: 10.1016/s0304-4165(03)00051-5. PMID: 12726989

Clinical prediction guides

On the mammalian acetone metabolism: from chemistry to clinical implications.
Kalapos MP
Biochim Biophys Acta 2003 May 2;1621(2):122-39. doi: 10.1016/s0304-4165(03)00051-5. PMID: 12726989
Gut and liver coordinated metabolic response following major torso injury.
Poggetti RS, Moore EE, Moore FA, Bensard DD, Parsons P, Anderson BO, Banerjee A
J Surg Res 1992 Jan;52(1):27-33. doi: 10.1016/0022-4804(92)90274-4. PMID: 1548864

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