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Elevated urinary collagen degradation products

MedGen UID:
1781194
•Concept ID:
C5539550
•
Finding
HPO: HP:0033384

Definition

Increased level in the urine of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease. [from HPO]

Professional guidelines

PubMed

Assessment of bone response to systemic therapy in an EORTC trial: preliminary experience with the use of collagen cross-link excretion. European Organization for Research and Treatment of Cancer.
Vinholes J, Coleman R, Lacombe D, Rose C, Tubiana-Hulin M, Bastit P, Wildiers J, Michel J, Leonard R, Nortier J, Mignolet F, Ford J
Br J Cancer 1999 Apr;80(1-2):221-8. doi: 10.1038/sj.bjc.6690506. PMID: 10390000Free PMC Article

Recent clinical studies

Etiology

Loss of legumain induces premature senescence and mediates aging-related renal fibrosis.
Wang D, Kang L, Chen C, Guo J, Du L, Zhou D, Li G, Zhang Y, Mi X, Zhang M, Liu S, Tan X
Aging Cell 2022 Mar;21(3):e13574. Epub 2022 Feb 23 doi: 10.1111/acel.13574. PMID: 35195326Free PMC Article
Benign prostatic hyperplasia/obstruction ameliorated using a soluble guanylate cyclase activator.
Zabbarova IV, Ikeda Y, Kozlowski MG, Tyagi P, Birder LA, Chakrabarty B, Perera SK, Dhir R, Straub AC, Sandner P, Andersson KE, Drake MJ, Fry CH, Kanai AJ
J Pathol 2022 Apr;256(4):442-454. Epub 2022 Feb 15 doi: 10.1002/path.5859. PMID: 34936088Free PMC Article
Free urinary glycosylated hydroxylysine as an indicator of altered collagen degradation in the mucopolysaccharidoses.
Patel N, Mills P, Davison J, Cleary M, Gissen P, Banushi B, Doykov I, Dorman M, Mills K, Heywood WE
J Inherit Metab Dis 2020 Mar;43(2):309-317. Epub 2019 Oct 1 doi: 10.1002/jimd.12166. PMID: 31452203
Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients.
Yamamoto M, Pinto-Sanchez MI, Bercik P, Britz-McKibbin P
Metabolomics 2019 May 20;15(6):82. doi: 10.1007/s11306-019-1543-0. PMID: 31111238
Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure.
Polhill TS, Saad S, Poronnik P, Fulcher GR, Pollock CA
Am J Physiol Renal Physiol 2004 Aug;287(2):F268-73. Epub 2004 Apr 27 doi: 10.1152/ajprenal.00084.2004. PMID: 15113747

Diagnosis

C-Terminal Cross-Linked Telopeptides of Type II Collagen as Biomarker for Radiological Knee Osteoarthritis: A Meta-Analysis.
Cheng H, Hao B, Sun J, Yin M
Cartilage 2020 Oct;11(4):512-520. Epub 2018 Sep 15 doi: 10.1177/1947603518798884. PMID: 30221987Free PMC Article
Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients.
Yamamoto M, Pinto-Sanchez MI, Bercik P, Britz-McKibbin P
Metabolomics 2019 May 20;15(6):82. doi: 10.1007/s11306-019-1543-0. PMID: 31111238
Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker.
Abe H, Matsubara T, Arai H, Doi T
Histol Histopathol 2011 Apr;26(4):531-41. doi: 10.14670/HH-26.531. PMID: 21360446
Molecular mechanism of diabetic nephropathy.
Lehmann R, Schleicher ED
Clin Chim Acta 2000 Jul;297(1-2):135-44. doi: 10.1016/s0009-8981(00)00240-0. PMID: 10841915
Purification of a mammary-derived growth factor from human milk and human mammary tumors.
Bano M, Salomon DS, Kidwell WR
J Biol Chem 1985 May 10;260(9):5745-52. PMID: 3921548

Therapy

Metformin abrogates the voiding dysfunction induced by prolonged methylglyoxal intake.
Oliveira AL, de Oliveira MG, Medeiros ML, Mónica FZ, Antunes E
Eur J Pharmacol 2021 Nov 5;910:174502. Epub 2021 Sep 10 doi: 10.1016/j.ejphar.2021.174502. PMID: 34516950
Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.
Tomlinson JA, Caplin B, Boruc O, Bruce-Cobbold C, Cutillas P, Dormann D, Faull P, Grossman RC, Khadayate S, Mas VR, Nitsch DD, Wang Z, Norman JT, Wilcox CS, Wheeler DC, Leiper J
J Am Soc Nephrol 2015 Dec;26(12):3045-59. Epub 2015 Apr 8 doi: 10.1681/ASN.2014030280. PMID: 25855779Free PMC Article
Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade.
Nishiyama A, Abe Y
J Pharmacol Sci 2006 Jan;100(1):9-16. Epub 2006 Jan 6 doi: 10.1254/jphs.fmj05003x3. PMID: 16397374
Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure.
Polhill TS, Saad S, Poronnik P, Fulcher GR, Pollock CA
Am J Physiol Renal Physiol 2004 Aug;287(2):F268-73. Epub 2004 Apr 27 doi: 10.1152/ajprenal.00084.2004. PMID: 15113747
Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels.
Ikehara K, Tada H, Kuboki K, Inokuchi T
Diabetes Res Clin Pract 2003 Jan;59(1):25-30. doi: 10.1016/s0168-8227(02)00194-8. PMID: 12482638

Prognosis

C-Terminal Cross-Linked Telopeptides of Type II Collagen as Biomarker for Radiological Knee Osteoarthritis: A Meta-Analysis.
Cheng H, Hao B, Sun J, Yin M
Cartilage 2020 Oct;11(4):512-520. Epub 2018 Sep 15 doi: 10.1177/1947603518798884. PMID: 30221987Free PMC Article
High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.
Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, Takeda Y, Fujita Y, Abiko A, Takiyama Y, Haneda M
Physiol Rep 2016 Mar;4(6) Epub 2016 Mar 31 doi: 10.14814/phy2.12730. PMID: 27033449Free PMC Article
Serum endostatin levels correlate with enhanced extracellular matrix degradation and poor patients' prognosis in bladder cancer.
Szarvas T, László V, Vom Dorp F, Reis H, Szendröi A, Romics I, Tilki D, Rübben H, Ergün S
Int J Cancer 2012 Jun 15;130(12):2922-9. Epub 2011 Sep 22 doi: 10.1002/ijc.26343. PMID: 21815140
New developments in biochemical markers for osteoporosis.
Garnero P, Delmas PD
Calcif Tissue Int 1996;59 Suppl 1:S2-9. doi: 10.1007/s002239900168. PMID: 8974724
Total and nondialyzable hydroxyproline excretion in Stage D2 prostate cancer.
Hopkins SC, Palmieri GM, Niell HB, Moinuddin M, Soloway MS
Cancer 1984 Jan 1;53(1):117-21. doi: 10.1002/1097-0142(19840101)53:1<117::aid-cncr2820530121>3.0.co;2-0. PMID: 6689994

Clinical prediction guides

Free urinary glycosylated hydroxylysine as an indicator of altered collagen degradation in the mucopolysaccharidoses.
Patel N, Mills P, Davison J, Cleary M, Gissen P, Banushi B, Doykov I, Dorman M, Mills K, Heywood WE
J Inherit Metab Dis 2020 Mar;43(2):309-317. Epub 2019 Oct 1 doi: 10.1002/jimd.12166. PMID: 31452203
High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.
Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, Takeda Y, Fujita Y, Abiko A, Takiyama Y, Haneda M
Physiol Rep 2016 Mar;4(6) Epub 2016 Mar 31 doi: 10.14814/phy2.12730. PMID: 27033449Free PMC Article
Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites.
Dai B, David V, Alshayeb HM, Showkat A, Gyamlani G, Horst RL, Wall BM, Quarles LD
Kidney Int 2012 Nov;82(10):1061-70. Epub 2012 Jun 27 doi: 10.1038/ki.2012.222. PMID: 22739976Free PMC Article
Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure.
Polhill TS, Saad S, Poronnik P, Fulcher GR, Pollock CA
Am J Physiol Renal Physiol 2004 Aug;287(2):F268-73. Epub 2004 Apr 27 doi: 10.1152/ajprenal.00084.2004. PMID: 15113747
Glycosaminoglycans in autoimmunity.
Hansen C, Otto E, Kuhlemann K, Förster G, Kahaly GJ
Clin Exp Rheumatol 1996 May-Jun;14 Suppl 15:S59-67. PMID: 8828950

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