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Glomerular parietal epithelial cell hypertrophy

MedGen UID:
1781179
•Concept ID:
C5539434
•
Finding
Synonym: Hypertrophy of the glomerular parietal epithelial cell
 
HPO: HP:0033225

Definition

An abnormality of the glomerular parietal epithelial cells characterized by (1) Increased parietal epithelial cell size, with or without cytoplasmic protein droplets; or (2) enlarged nuclei with prominent nucleoli. Both features can be present [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular parietal epithelial cell hypertrophy

Recent clinical studies

Etiology

Morphological features of primary focal and segmental glomerulosclerosis.
Noël LH
Nephrol Dial Transplant 1999;14 Suppl 3:53-7. doi: 10.1093/ndt/14.suppl_3.53. PMID: 10382983

Diagnosis

Origin of hyperplastic epithelial cells in idiopathic collapsing glomerulopathy.
Kihara I, Yaoita E, Kawasaki K, Yamamoto T, Hara M, Yanagihara T
Histopathology 1999 Jun;34(6):537-47. doi: 10.1111/j.1365-2559.1999.00670.x. PMID: 10383699

Therapy

Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes.
Benedetti V, Lavecchia AM, Locatelli M, Brizi V, Corna D, Todeschini M, Novelli R, Benigni A, Zoja C, Remuzzi G, Xinaris C
JCI Insight 2019 Sep 19;4(18) doi: 10.1172/jci.insight.130249. PMID: 31534055Free PMC Article
mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.
Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF
JCI Insight 2019 Sep 19;4(18) doi: 10.1172/jci.insight.99271. PMID: 31534053Free PMC Article
FSGS as an Adaptive Response to Growth-Induced Podocyte Stress.
Nishizono R, Kikuchi M, Wang SQ, Chowdhury M, Nair V, Hartman J, Fukuda A, Wickman L, Hodgin JB, Bitzer M, Naik A, Wiggins J, Kretzler M, Wiggins RC
J Am Soc Nephrol 2017 Oct;28(10):2931-2945. Epub 2017 Jul 18 doi: 10.1681/ASN.2017020174. PMID: 28720684Free PMC Article

Clinical prediction guides

Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells.
Kawaguchi T, Hasegawa K, Yasuda I, Muraoka H, Umino H, Tokuyama H, Hashiguchi A, Wakino S, Itoh H
Sci Rep 2021 Jan 15;11(1):1515. doi: 10.1038/s41598-021-81027-8. PMID: 33452384Free PMC Article
Origin of hyperplastic epithelial cells in idiopathic collapsing glomerulopathy.
Kihara I, Yaoita E, Kawasaki K, Yamamoto T, Hara M, Yanagihara T
Histopathology 1999 Jun;34(6):537-47. doi: 10.1111/j.1365-2559.1999.00670.x. PMID: 10383699
Morphological features of primary focal and segmental glomerulosclerosis.
Noël LH
Nephrol Dial Transplant 1999;14 Suppl 3:53-7. doi: 10.1093/ndt/14.suppl_3.53. PMID: 10382983

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