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Reversible airflow obstruction

MedGen UID:
1779583
•Concept ID:
C5539668
•
Finding
Synonym: Reversible pulmonary obstruction
 
HPO: HP:0033540

Definition

Airflow obstruction with a significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReversible airflow obstruction

Professional guidelines

PubMed

Asthma Management in Children.
Shipp CL, Gergen PJ, Gern JE, Matsui EC, Guilbert TW
J Allergy Clin Immunol Pract 2023 Jan;11(1):9-18. Epub 2022 Nov 9 doi: 10.1016/j.jaip.2022.10.031. PMID: 36334702
Clinical updates on the management of asthma.
Bollmeier S
Am J Manag Care 2017 Feb;23(1 Suppl):S3-S11. PMID: 28978210
The clinical and integrated management of COPD.
Bettoncelli G, Blasi F, Brusasco V, Centanni S, Corrado A, De Benedetto F, De Michele F, Di Maria GU, Donner CF, Falcone F, Mereu C, Nardini S, Pasqua F, Polverino M, Rossi A, Sanguinetti CM
Sarcoidosis Vasc Diffuse Lung Dis 2014 May 12;31 Suppl 1:3-21. PMID: 24820963

Recent clinical studies

Etiology

Asthma Management in Children.
Shipp CL, Gergen PJ, Gern JE, Matsui EC, Guilbert TW
J Allergy Clin Immunol Pract 2023 Jan;11(1):9-18. Epub 2022 Nov 9 doi: 10.1016/j.jaip.2022.10.031. PMID: 36334702
Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study.
Buhr RG, Barjaktarevic IZ, Quibrera PM, Bateman LA, Bleecker ER, Couper DJ, Curtis JL, Dolezal BA, Han MK, Hansel NN, Krishnan JA, Martinez FJ, McKleroy W, Paine R 3rd, Rennard SI, Tashkin DP, Woodruff PG, Kanner RE, Cooper CB; SPIROMICS Investigators
Am J Respir Crit Care Med 2022 Sep 1;206(5):554-562. doi: 10.1164/rccm.202201-0094OC. PMID: 35549640Free PMC Article
Adult-onset asthma.
Burdon J
Aust Fam Physician 2015 Aug;44(8):554-7. PMID: 26510141
Lung consequences in adults born prematurely.
Bolton CE, Bush A, Hurst JR, Kotecha S, McGarvey L
Thorax 2015 Jun;70(6):574-80. Epub 2015 Mar 30 doi: 10.1136/thoraxjnl-2014-206590. PMID: 25825005
An overview of asthma.
Sims JM
Dimens Crit Care Nurs 2006 Nov-Dec;25(6):264-8. doi: 10.1097/00003465-200611000-00004. PMID: 17122656

Diagnosis

Asthma Management in Children.
Shipp CL, Gergen PJ, Gern JE, Matsui EC, Guilbert TW
J Allergy Clin Immunol Pract 2023 Jan;11(1):9-18. Epub 2022 Nov 9 doi: 10.1016/j.jaip.2022.10.031. PMID: 36334702
Extracellular Vesicles and Asthma-More Than Just a Co-Existence.
Alashkar Alhamwe B, Potaczek DP, Miethe S, Alhamdan F, Hintz L, Magomedov A, Garn H
Int J Mol Sci 2021 May 7;22(9) doi: 10.3390/ijms22094984. PMID: 34067156Free PMC Article
Clinical updates on the management of asthma.
Bollmeier S
Am J Manag Care 2017 Feb;23(1 Suppl):S3-S11. PMID: 28978210
Adult-onset asthma.
Burdon J
Aust Fam Physician 2015 Aug;44(8):554-7. PMID: 26510141
An overview of asthma.
Sims JM
Dimens Crit Care Nurs 2006 Nov-Dec;25(6):264-8. doi: 10.1097/00003465-200611000-00004. PMID: 17122656

Therapy

Asthma and Comorbid Conditions-Pulmonary Comorbidity.
Gibson PG, McDonald VM, Granchelli A, Olin JT
J Allergy Clin Immunol Pract 2021 Nov;9(11):3868-3875. Epub 2021 Sep 4 doi: 10.1016/j.jaip.2021.08.028. PMID: 34492401
Clinical updates on the management of asthma.
Bollmeier S
Am J Manag Care 2017 Feb;23(1 Suppl):S3-S11. PMID: 28978210
Adult-onset asthma.
Burdon J
Aust Fam Physician 2015 Aug;44(8):554-7. PMID: 26510141
Methylxanthines in asthma.
Tilley SL
Handb Exp Pharmacol 2011;(200):439-56. doi: 10.1007/978-3-642-13443-2_17. PMID: 20859807
An overview of asthma.
Sims JM
Dimens Crit Care Nurs 2006 Nov-Dec;25(6):264-8. doi: 10.1097/00003465-200611000-00004. PMID: 17122656

Prognosis

Epigenetic regulation of immune function in asthma.
Sharma S, Yang IV, Schwartz DA
J Allergy Clin Immunol 2022 Aug;150(2):259-265. Epub 2022 Jun 16 doi: 10.1016/j.jaci.2022.06.002. PMID: 35717251Free PMC Article
Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study.
Buhr RG, Barjaktarevic IZ, Quibrera PM, Bateman LA, Bleecker ER, Couper DJ, Curtis JL, Dolezal BA, Han MK, Hansel NN, Krishnan JA, Martinez FJ, McKleroy W, Paine R 3rd, Rennard SI, Tashkin DP, Woodruff PG, Kanner RE, Cooper CB; SPIROMICS Investigators
Am J Respir Crit Care Med 2022 Sep 1;206(5):554-562. doi: 10.1164/rccm.202201-0094OC. PMID: 35549640Free PMC Article
Multidimensional approach for the proper management of a complex chronic patient with chronic obstructive pulmonary disease.
Rogliani P, Brusasco V, Fabbri L, Ungar A, Muscianisi E, Barisone I, Corsini A, De Angelis G
Expert Rev Respir Med 2018 Feb;12(2):103-112. Epub 2017 Dec 18 doi: 10.1080/17476348.2018.1417041. PMID: 29241393
The clinical and integrated management of COPD.
Bettoncelli G, Blasi F, Brusasco V, Centanni S, Corrado A, De Benedetto F, De Michele F, Di Maria GU, Donner CF, Falcone F, Mereu C, Nardini S, Pasqua F, Polverino M, Rossi A, Sanguinetti CM
Sarcoidosis Vasc Diffuse Lung Dis 2014 May 12;31 Suppl 1:3-21. PMID: 24820963
Lymphangioleiomyomatosis: a clinical update.
McCormack FX
Chest 2008 Feb;133(2):507-16. doi: 10.1378/chest.07-0898. PMID: 18252917

Clinical prediction guides

Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study.
Buhr RG, Barjaktarevic IZ, Quibrera PM, Bateman LA, Bleecker ER, Couper DJ, Curtis JL, Dolezal BA, Han MK, Hansel NN, Krishnan JA, Martinez FJ, McKleroy W, Paine R 3rd, Rennard SI, Tashkin DP, Woodruff PG, Kanner RE, Cooper CB; SPIROMICS Investigators
Am J Respir Crit Care Med 2022 Sep 1;206(5):554-562. doi: 10.1164/rccm.202201-0094OC. PMID: 35549640Free PMC Article
The clinical and integrated management of COPD.
Bettoncelli G, Blasi F, Brusasco V, Centanni S, Corrado A, De Benedetto F, De Michele F, Di Maria GU, Donner CF, Falcone F, Mereu C, Nardini S, Pasqua F, Polverino M, Rossi A, Sanguinetti CM
Sarcoidosis Vasc Diffuse Lung Dis 2014 May 12;31 Suppl 1:3-21. PMID: 24820963
Recent advances in asthma biomarker research.
Leung TF, Ko FW, Wong GW
Ther Adv Respir Dis 2013 Oct;7(5):297-308. Epub 2013 Aug 1 doi: 10.1177/1753465813496863. PMID: 23907809
Methylxanthines in asthma.
Tilley SL
Handb Exp Pharmacol 2011;(200):439-56. doi: 10.1007/978-3-642-13443-2_17. PMID: 20859807
Reversible airflow obstruction in lymphangioleiomyomatosis.
Taveira-DaSilva AM, Steagall WK, Rabel A, Hathaway O, Harari S, Cassandro R, Stylianou M, Moss J
Chest 2009 Dec;136(6):1596-1603. Epub 2009 May 15 doi: 10.1378/chest.09-0624. PMID: 19447921Free PMC Article

Recent systematic reviews

The cost-effectiveness of domiciliary non-invasive ventilation in patients with end-stage chronic obstructive pulmonary disease: a systematic review and economic evaluation.
Dretzke J, Blissett D, Dave C, Mukherjee R, Price M, Bayliss S, Wu X, Jordan R, Jowett S, Turner AM, Moore D
Health Technol Assess 2015 Oct;19(81):1-246. doi: 10.3310/hta19810. PMID: 26470875Free PMC Article

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