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Metastatic Anal Canal Squamous Cell Carcinoma

MedGen UID:
1779300
•Concept ID:
C5446481
•
Neoplastic Process

Definition

Anal canal squamous cell carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Anal Canal Squamous Cell Carcinoma

Professional guidelines

PubMed

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, Grem JL, Hecht JR, Hoffe S, Hubbard J, Hunt S, Hussan H, Jeck W, Johung KL, Joseph N, Kirilcuk N, Krishnamurthi S, Maratt J, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stotsky-Himelfarb E, Tavakkoli A, Willett CG, Williams G, Algieri F, Gurski L, Stehman K
J Natl Compr Canc Netw 2023 Jun;21(6):653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125
Diagnosis and Treatment of Anal Squamous Cell Carcinoma.
Gardner IH, Watson KM
Dis Colon Rectum 2020 Oct;63(10):1358-1361. doi: 10.1097/DCR.0000000000001791. PMID: 32969877
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616

Recent clinical studies

Etiology

Anal Cancer and Anal Cancer Screening.
Cohen CM, Clarke MA
Clin Obstet Gynecol 2023 Sep 1;66(3):516-533. Epub 2023 Jul 13 doi: 10.1097/GRF.0000000000000789. PMID: 37439541Free PMC Article
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Definitive radiotherapy for squamous cell carcinoma of the anal canal.
Rabbani AN, Zlotecki RA, Kirwan J, George TJ Jr, Morris CG, Rout WR, Mendenhall WM
Am J Clin Oncol 2010 Feb;33(1):47-51. doi: 10.1097/COC.0b013e31819e2be2. PMID: 19704368

Diagnosis

Anal Cancer and Anal Cancer Screening.
Cohen CM, Clarke MA
Clin Obstet Gynecol 2023 Sep 1;66(3):516-533. Epub 2023 Jul 13 doi: 10.1097/GRF.0000000000000789. PMID: 37439541Free PMC Article
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Diagnosis and Treatment of Anal Squamous Cell Carcinoma.
Gardner IH, Watson KM
Dis Colon Rectum 2020 Oct;63(10):1358-1361. doi: 10.1097/DCR.0000000000001791. PMID: 32969877
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Definitive radiotherapy for squamous cell carcinoma of the anal canal.
Rabbani AN, Zlotecki RA, Kirwan J, George TJ Jr, Morris CG, Rout WR, Mendenhall WM
Am J Clin Oncol 2010 Feb;33(1):47-51. doi: 10.1097/COC.0b013e31819e2be2. PMID: 19704368

Therapy

Anal Cancer and Anal Cancer Screening.
Cohen CM, Clarke MA
Clin Obstet Gynecol 2023 Sep 1;66(3):516-533. Epub 2023 Jul 13 doi: 10.1097/GRF.0000000000000789. PMID: 37439541Free PMC Article
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Immunotherapy in Anal Cancer.
Phuong L, Rajdev L
Curr Oncol Rep 2020 Jul 11;22(9):94. doi: 10.1007/s11912-020-00946-3. PMID: 32651760
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Definitive radiotherapy for squamous cell carcinoma of the anal canal.
Rabbani AN, Zlotecki RA, Kirwan J, George TJ Jr, Morris CG, Rout WR, Mendenhall WM
Am J Clin Oncol 2010 Feb;33(1):47-51. doi: 10.1097/COC.0b013e31819e2be2. PMID: 19704368

Prognosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
A Phase II Study of Capecitabine/Oxaliplatin With Concurrent Radiotherapy in Locally Advanced Squamous Cell Carcinoma of the Anal Canal.
Eng C, Jácome AA, Das P, Chang GJ, Rodriguez-Bigas M, Skibber JM, Wolff RA, Qiao W, Xing Y, Sethi S, Ohinata A, Crane CH
Clin Colorectal Cancer 2019 Dec;18(4):301-306. Epub 2019 Jul 2 doi: 10.1016/j.clcc.2019.06.003. PMID: 31350201
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Definitive radiotherapy for squamous cell carcinoma of the anal canal.
Rabbani AN, Zlotecki RA, Kirwan J, George TJ Jr, Morris CG, Rout WR, Mendenhall WM
Am J Clin Oncol 2010 Feb;33(1):47-51. doi: 10.1097/COC.0b013e31819e2be2. PMID: 19704368
Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes.
Leroy J, Jamali F, Forbes L, Smith M, Rubino F, Mutter D, Marescaux J
Surg Endosc 2004 Feb;18(2):281-9. Epub 2003 Dec 29 doi: 10.1007/s00464-002-8877-8. PMID: 14691716

Clinical prediction guides

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Anal cytology screening in men who have sex with men with HIV at a university hospital in Bogotá, Colombia.
Ordoñez-Blanco IT, Martínez-Vernaza S, Blair KJ, Quiroga C, Lowenstein E, Lombana Amaya LJ, Clark J, Lake JE, Valderrama-Beltrán SL
Int J STD AIDS 2022 Jun;33(7):701-708. Epub 2022 Apr 30 doi: 10.1177/09564624221097742. PMID: 35491739Free PMC Article
Nonplatinum-based therapy with Paclitaxel and Capecitabine for advanced squamous cell carcinomas of the anal canal: A population-based Danish anal cancer group study.
Truelsen CG, Serup-Hansen E, Storm KS, Havelund BM, Kronborg CS, Spindler KG
Cancer Med 2021 May;10(10):3224-3230. Epub 2021 May 7 doi: 10.1002/cam4.3886. PMID: 33960701Free PMC Article
Anal canal cancer: management of inguinal nodes and benefit of prophylactic inguinal irradiation (CORS-03 Study).
Ortholan C, Resbeut M, Hannoun-Levi JM, Teissier E, Gerard JP, Ronchin P, Zaccariotto A, Minsat M, Benezery K, François E, Salem N, Ellis S, Azria D, Champetier C, Gross E, Cowen D
Int J Radiat Oncol Biol Phys 2012 Apr 1;82(5):1988-95. Epub 2011 May 11 doi: 10.1016/j.ijrobp.2011.02.010. PMID: 21570207
Magnetic resonance imaging assessment of squamous cell carcinoma of the anal canal before and after chemoradiation: can MRI predict for eventual clinical outcome?
Goh V, Gollub FK, Liaw J, Wellsted D, Przybytniak I, Padhani AR, Glynne-Jones R
Int J Radiat Oncol Biol Phys 2010 Nov 1;78(3):715-21. Epub 2010 Feb 18 doi: 10.1016/j.ijrobp.2009.08.055. PMID: 20171812

Recent systematic reviews

Outcome following local excision of T1 anal cancers-a systematic review.
Pedersen TB, Kildsig J, Serup-Hansen E, Gocht-Jensen P, Klein MF
Int J Colorectal Dis 2020 Sep;35(9):1663-1671. Epub 2020 Jul 15 doi: 10.1007/s00384-020-03687-8. PMID: 32671458

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