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Advanced Salivary Gland Carcinoma

MedGen UID:
1779017
•Concept ID:
C5447974
•
Neoplastic Process

Definition

Salivary gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Salivary Gland Carcinoma

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Recent clinical studies

Etiology

STRN-ALK Fusion in Advanced Salivary Gland Carcinoma With Response to Anaplastic Lymphoma Kinase Inhibition: Case Report and Literature Review.
Kaur V, Zadeh S
WMJ 2024 Sep;123(4):315-319. PMID: 39284095
Salivary gland carcinoma (SGC) with perineural spread and/or positive resection margin - high locoregional control rates after photon (chemo) radiotherapy - experience from a monocentric analysis.
Haderlein M, Scherl C, Semrau S, Lettmaier S, Hecht M, Putz F, Iro H, Agaimy A, Fietkau R
Radiat Oncol 2019 Apr 23;14(1):68. doi: 10.1186/s13014-019-1260-x. PMID: 31014362Free PMC Article
Adjuvant chemoradiotherapy versus with radiotherapy alone for locally advanced salivary gland carcinoma among older patients.
Tanvetyanon T, Fisher K, Caudell J, Otto K, Padhya T, Trotti A
Head Neck 2016 Jun;38(6):863-70. Epub 2015 Sep 4 doi: 10.1002/hed.24172. PMID: 26340707
Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck.
Aihara T, Morita N, Kamitani N, Kumada H, Ono K, Hiratsuka J, Harada T
Int J Clin Oncol 2014;19(3):437-44. Epub 2013 Jun 25 doi: 10.1007/s10147-013-0580-3. PMID: 23797210
Cisplatin in advanced salivary gland carcinoma. A phase II study of 25 patients.
Licitra L, Marchini S, Spinazzè S, Rossi A, Rocca A, Grandi C, Molinari R
Cancer 1991 Nov 1;68(9):1874-7. doi: 10.1002/1097-0142(19911101)68:9<1874::aid-cncr2820680904>3.0.co;2-s. PMID: 1913539

Diagnosis

STRN-ALK Fusion in Advanced Salivary Gland Carcinoma With Response to Anaplastic Lymphoma Kinase Inhibition: Case Report and Literature Review.
Kaur V, Zadeh S
WMJ 2024 Sep;123(4):315-319. PMID: 39284095
Salivary gland carcinoma (SGC) with perineural spread and/or positive resection margin - high locoregional control rates after photon (chemo) radiotherapy - experience from a monocentric analysis.
Haderlein M, Scherl C, Semrau S, Lettmaier S, Hecht M, Putz F, Iro H, Agaimy A, Fietkau R
Radiat Oncol 2019 Apr 23;14(1):68. doi: 10.1186/s13014-019-1260-x. PMID: 31014362Free PMC Article
Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck.
Aihara T, Morita N, Kamitani N, Kumada H, Ono K, Hiratsuka J, Harada T
Int J Clin Oncol 2014;19(3):437-44. Epub 2013 Jun 25 doi: 10.1007/s10147-013-0580-3. PMID: 23797210

Therapy

Evaluation of pembrolizumab monotherapy in patients with previously treated advanced salivary gland carcinoma in the phase 2 KEYNOTE-158 study.
Even C, Delord JP, Price KA, Nakagawa K, Oh DY, Burge M, Chung HC, Doi T, Fakih M, Takahashi S, Yao L, Jin F, Norwood K, Hansen AR
Eur J Cancer 2022 Aug;171:259-268. Epub 2022 Jun 28 doi: 10.1016/j.ejca.2022.05.007. PMID: 35777186
Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study.
Kurzrock R, Bowles DW, Kang H, Meric-Bernstam F, Hainsworth J, Spigel DR, Bose R, Burris H, Sweeney CJ, Beattie MS, Blotner S, Schulze K, Cuchelkar V, Swanton C
Ann Oncol 2020 Mar;31(3):412-421. Epub 2019 Dec 9 doi: 10.1016/j.annonc.2019.11.018. PMID: 32067683Free PMC Article
Adjuvant chemoradiotherapy versus with radiotherapy alone for locally advanced salivary gland carcinoma among older patients.
Tanvetyanon T, Fisher K, Caudell J, Otto K, Padhya T, Trotti A
Head Neck 2016 Jun;38(6):863-70. Epub 2015 Sep 4 doi: 10.1002/hed.24172. PMID: 26340707
Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck.
Aihara T, Morita N, Kamitani N, Kumada H, Ono K, Hiratsuka J, Harada T
Int J Clin Oncol 2014;19(3):437-44. Epub 2013 Jun 25 doi: 10.1007/s10147-013-0580-3. PMID: 23797210
Cisplatin in advanced salivary gland carcinoma. A phase II study of 25 patients.
Licitra L, Marchini S, Spinazzè S, Rossi A, Rocca A, Grandi C, Molinari R
Cancer 1991 Nov 1;68(9):1874-7. doi: 10.1002/1097-0142(19911101)68:9<1874::aid-cncr2820680904>3.0.co;2-s. PMID: 1913539

Prognosis

Salivary gland carcinoma (SGC) with perineural spread and/or positive resection margin - high locoregional control rates after photon (chemo) radiotherapy - experience from a monocentric analysis.
Haderlein M, Scherl C, Semrau S, Lettmaier S, Hecht M, Putz F, Iro H, Agaimy A, Fietkau R
Radiat Oncol 2019 Apr 23;14(1):68. doi: 10.1186/s13014-019-1260-x. PMID: 31014362Free PMC Article
Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck.
Aihara T, Morita N, Kamitani N, Kumada H, Ono K, Hiratsuka J, Harada T
Int J Clin Oncol 2014;19(3):437-44. Epub 2013 Jun 25 doi: 10.1007/s10147-013-0580-3. PMID: 23797210
Cisplatin in advanced salivary gland carcinoma. A phase II study of 25 patients.
Licitra L, Marchini S, Spinazzè S, Rossi A, Rocca A, Grandi C, Molinari R
Cancer 1991 Nov 1;68(9):1874-7. doi: 10.1002/1097-0142(19911101)68:9<1874::aid-cncr2820680904>3.0.co;2-s. PMID: 1913539

Clinical prediction guides

Evaluation of pembrolizumab monotherapy in patients with previously treated advanced salivary gland carcinoma in the phase 2 KEYNOTE-158 study.
Even C, Delord JP, Price KA, Nakagawa K, Oh DY, Burge M, Chung HC, Doi T, Fakih M, Takahashi S, Yao L, Jin F, Norwood K, Hansen AR
Eur J Cancer 2022 Aug;171:259-268. Epub 2022 Jun 28 doi: 10.1016/j.ejca.2022.05.007. PMID: 35777186
Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study.
Kurzrock R, Bowles DW, Kang H, Meric-Bernstam F, Hainsworth J, Spigel DR, Bose R, Burris H, Sweeney CJ, Beattie MS, Blotner S, Schulze K, Cuchelkar V, Swanton C
Ann Oncol 2020 Mar;31(3):412-421. Epub 2019 Dec 9 doi: 10.1016/j.annonc.2019.11.018. PMID: 32067683Free PMC Article
Salivary gland carcinoma (SGC) with perineural spread and/or positive resection margin - high locoregional control rates after photon (chemo) radiotherapy - experience from a monocentric analysis.
Haderlein M, Scherl C, Semrau S, Lettmaier S, Hecht M, Putz F, Iro H, Agaimy A, Fietkau R
Radiat Oncol 2019 Apr 23;14(1):68. doi: 10.1186/s13014-019-1260-x. PMID: 31014362Free PMC Article
Adjuvant chemoradiotherapy versus with radiotherapy alone for locally advanced salivary gland carcinoma among older patients.
Tanvetyanon T, Fisher K, Caudell J, Otto K, Padhya T, Trotti A
Head Neck 2016 Jun;38(6):863-70. Epub 2015 Sep 4 doi: 10.1002/hed.24172. PMID: 26340707
Cisplatin, doxorubicin and cyclophosphamide in advanced salivary gland carcinoma. A phase II trial of 22 patients.
Licitra L, Cavina R, Grandi C, Palma SD, Guzzo M, Demicheli R, Molinari R
Ann Oncol 1996 Aug;7(6):640-2. doi: 10.1093/oxfordjournals.annonc.a010684. PMID: 8879381

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