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Advanced Nasopharyngeal Carcinoma

MedGen UID:
1778755
•Concept ID:
C5446568
•
Neoplastic Process

Definition

Nasopharyngeal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Nasopharyngeal Carcinoma

Professional guidelines

PubMed

Immunotherapy for the treatment of advanced nasopharyngeal carcinoma: a promising new era.
Wang S, Chen S, Zhong Q, Liu Y
J Cancer Res Clin Oncol 2023 May;149(5):2071-2079. Epub 2022 Jul 25 doi: 10.1007/s00432-022-04214-8. PMID: 35876949
A deep learning-based radiomic nomogram for prognosis and treatment decision in advanced nasopharyngeal carcinoma: A multicentre study.
Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Management of Nasopharyngeal Carcinoma: Is Adjuvant Therapy Needed?
Lee VH, Lam KO, Chang AT, Lam TC, Chiang CL, So TH, Choi CW, Lee AW
J Oncol Pract 2018 Oct;14(10):594-602. doi: 10.1200/JOP.18.00219. PMID: 30312564

Recent clinical studies

Therapy

Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Gemcitabine Plus Cisplatin Versus Fluorouracil Plus Cisplatin as First-Line Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: Final Overall Survival Analysis of GEM20110714 Phase III Study.
Hong S, Zhang Y, Yu G, Peng P, Peng J, Jia J, Wu X, Huang Y, Yang Y, Lin Q, Xi X, Xu M, Chen D, Lu X, Wang R, Cao X, Chen X, Lin Z, Xiong J, Lin Q, Xie C, Li Z, Pan J, Li J, Wu S, Lian Y, Yang Q, Zhao C, Fang W, Zhang L
J Clin Oncol 2021 Oct 10;39(29):3273-3282. Epub 2021 Aug 11 doi: 10.1200/JCO.21.00396. PMID: 34379443Free PMC Article
Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.
Chen YP, Liu X, Zhou Q, Yang KY, Jin F, Zhu XD, Shi M, Hu GQ, Hu WH, Sun Y, Wu HF, Wu H, Lin Q, Wang H, Tian Y, Zhang N, Wang XC, Shen LF, Liu ZZ, Huang J, Luo XL, Li L, Zang J, Mei Q, Zheng BM, Yue D, Xu J, Wu SG, Shi YX, Mao YP, Chen L, Li WF, Zhou GQ, Sun R, Guo R, Zhang Y, Xu C, Lv JW, Guo Y, Feng HX, Tang LL, Xie FY, Sun Y, Ma J
Lancet 2021 Jul 24;398(10297):303-313. Epub 2021 Jun 7 doi: 10.1016/S0140-6736(21)01123-5. PMID: 34111416
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma.
Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, Cheng ZB, Wang SY, Tian Y, Wang XC, Sun Y, Li JG, Li WF, Li YH, Tang LL, Mao YP, Zhou GQ, Sun R, Liu X, Guo R, Long GX, Liang SQ, Li L, Huang J, Long JH, Zang J, Liu QD, Zou L, Su QF, Zheng BM, Xiao Y, Guo Y, Han F, Mo HY, Lv JW, Du XJ, Xu C, Liu N, Li YQ, Chua MLK, Xie FY, Sun Y, Ma J
N Engl J Med 2019 Sep 19;381(12):1124-1135. Epub 2019 May 31 doi: 10.1056/NEJMoa1905287. PMID: 31150573

Prognosis

Enhancing efficacy and reducing toxicity: Therapeutic optimization in locoregionally advanced nasopharyngeal carcinoma.
Jiang W, Lv JW, Tang LL, Sun Y, Chen YP, Ma J
Cell Rep Med 2024 Jun 18;5(6):101594. Epub 2024 Jun 5 doi: 10.1016/j.xcrm.2024.101594. PMID: 38843843Free PMC Article
Immunotherapy for the treatment of advanced nasopharyngeal carcinoma: a promising new era.
Wang S, Chen S, Zhong Q, Liu Y
J Cancer Res Clin Oncol 2023 May;149(5):2071-2079. Epub 2022 Jul 25 doi: 10.1007/s00432-022-04214-8. PMID: 35876949
A deep learning-based radiomic nomogram for prognosis and treatment decision in advanced nasopharyngeal carcinoma: A multicentre study.
Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study.
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165
Progresses and Challenges in Chemotherapy for Loco- Regionally Advanced Nasopharyngeal Carcinoma.
Liang ZG, Chen ZT, Li L, Qu S, Zhu XD
Asian Pac J Cancer Prev 2015;16(12):4825-32. doi: 10.7314/apjcp.2015.16.12.4825. PMID: 26163598

Clinical prediction guides

Induction Chemotherapy Followed by Radiotherapy vs Chemoradiotherapy in Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Dai J, Zhang B, Su Y, Pan Y, Ye Z, Cai R, Qin G, Kong X, Mo Y, Zhang R, Liu Z, Xie Y, Ruan X, Jiang W
JAMA Oncol 2024 Apr 1;10(4):456-463. doi: 10.1001/jamaoncol.2023.6552. PMID: 38329737Free PMC Article
A deep learning-based radiomic nomogram for prognosis and treatment decision in advanced nasopharyngeal carcinoma: A multicentre study.
Zhong L, Dong D, Fang X, Zhang F, Zhang N, Zhang L, Fang M, Jiang W, Liang S, Li C, Liu Y, Zhao X, Cao R, Shan H, Hu Z, Ma J, Tang L, Tian J
EBioMedicine 2021 Aug;70:103522. Epub 2021 Aug 11 doi: 10.1016/j.ebiom.2021.103522. PMID: 34391094Free PMC Article
Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.
Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi YR, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Liu Z, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Feng H, Yao S, Keegan P, Xu RH
Nat Med 2021 Sep;27(9):1536-1543. Epub 2021 Aug 2 doi: 10.1038/s41591-021-01444-0. PMID: 34341578
Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.
Chen YP, Liu X, Zhou Q, Yang KY, Jin F, Zhu XD, Shi M, Hu GQ, Hu WH, Sun Y, Wu HF, Wu H, Lin Q, Wang H, Tian Y, Zhang N, Wang XC, Shen LF, Liu ZZ, Huang J, Luo XL, Li L, Zang J, Mei Q, Zheng BM, Yue D, Xu J, Wu SG, Shi YX, Mao YP, Chen L, Li WF, Zhou GQ, Sun R, Guo R, Zhang Y, Xu C, Lv JW, Guo Y, Feng HX, Tang LL, Xie FY, Sun Y, Ma J
Lancet 2021 Jul 24;398(10297):303-313. Epub 2021 Jun 7 doi: 10.1016/S0140-6736(21)01123-5. PMID: 34111416
Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study.
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165

Recent systematic reviews

Anti-angiogenesis agents plus chemoradiotherapy for locally advanced nasopharyngeal cancer: a systematic review and meta-analysis.
Sun X, Zhu Y, Lou Y, Lu X, Wang B, Yu D, Guo Y, Xin Y
Eur Arch Otorhinolaryngol 2024 Aug;281(8):3929-3941. Epub 2024 Apr 16 doi: 10.1007/s00405-024-08545-9. PMID: 38625559
Immunotherapy in the First-Line Treatment of Advanced Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis.
Guven DC, Stephen B, Sahin TK, Cakir IY, Aksoy S
Laryngoscope 2024 Jan;134(1):7-17. Epub 2023 May 25 doi: 10.1002/lary.30754. PMID: 37227161
Optimal induction chemotherapy regimen for locoregionally advanced nasopharyngeal carcinoma: an update Bayesian network meta-analysis.
Wu Q, Li S, Liu J, Zhong Y
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5057-5069. Epub 2022 Jun 29 doi: 10.1007/s00405-022-07435-2. PMID: 35767064
Meta-Analysis on Induction Chemotherapy in Locally Advanced Nasopharyngeal Carcinoma.
Mané M, Benkhaled S, Dragan T, Paesmans M, Beauvois S, Lalami Y, Szturz P, Gaye PM, Vermorken JB, Van Gestel D
Oncologist 2021 Jan;26(1):e130-e141. Epub 2020 Oct 1 doi: 10.1002/ONCO.13520. PMID: 32924198Free PMC Article
Chemoradiotherapy regimens for locoregionally advanced nasopharyngeal carcinoma: A Bayesian network meta-analysis.
Yan M, Kumachev A, Siu LL, Chan KK
Eur J Cancer 2015 Aug;51(12):1570-9. Epub 2015 Jun 1 doi: 10.1016/j.ejca.2015.04.027. PMID: 26044925

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