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Metastatic Intrahepatic Cholangiocarcinoma

MedGen UID:
1777207
•Concept ID:
C5419543
•
Neoplastic Process

Definition

Intrahepatic cholangiocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Intrahepatic Cholangiocarcinoma

Professional guidelines

PubMed

Futibatinib: A Potent and Irreversible Inhibitor of Fibroblast Growth Factor Receptors for Treatment of the Bile Duct Cancer.
De SK
Curr Med Chem 2024;31(6):666-670. doi: 10.2174/0929867330666230416152913. PMID: 37062061
Is there a role for Ytrrium-90 in the treatment of unresectable and metastatic intrahepatic cholangiocarcinoma?
Shaker TM, Chung C, Varma MK, Doherty MG, Wolf AM, Chung MH, Assifi MM
Am J Surg 2018 Mar;215(3):467-470. Epub 2018 Feb 2 doi: 10.1016/j.amjsurg.2017.11.022. PMID: 29395023

Recent clinical studies

Etiology

Locoregional therapy combined with systemic therapy (LRT + ST) for unresectable and metastatic intrahepatic cholangiocarcinoma: a systematic review and meta-analysis.
Zhang M, Qi W, Qiu X, Yu C, Qiu W, Wang S, Qiu Z
Radiol Oncol 2023 Dec 1;57(4):419-429. Epub 2023 Nov 30 doi: 10.2478/raon-2023-0059. PMID: 38038416Free PMC Article
Transarterial chemoembolization plus lenvatinib with or without a PD-1 inhibitor for advanced and metastatic intrahepatic cholangiocarcinoma: a retrospective real-world study.
Ning Z, Xie L, Yan X, Hua Y, Shi W, Lin J, Xu L, Meng Z
Br J Radiol 2023 Oct;96(1150):20230079. Epub 2023 Sep 3 doi: 10.1259/bjr.20230079. PMID: 37660471Free PMC Article
Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis.
Garajová I, Gelsomino F, Salati M, Leonardi F, De Lorenzo S, Granito A, Tovoli F
Curr Oncol 2023 Feb 22;30(3):2613-2624. doi: 10.3390/curroncol30030199. PMID: 36975412Free PMC Article
Intrahepatic cholangiocarcinoma: Is there a role for liver transplantation?
Kim P, Littau M, Baker TB, Abdelsattar Z, Tonelli C, Bunn C, Kulshrestha S, Luchette FA, Baker MS
Surgery 2022 Mar;171(3):741-746. Epub 2021 Dec 8 doi: 10.1016/j.surg.2021.09.034. PMID: 34895770
Is there a role for Ytrrium-90 in the treatment of unresectable and metastatic intrahepatic cholangiocarcinoma?
Shaker TM, Chung C, Varma MK, Doherty MG, Wolf AM, Chung MH, Assifi MM
Am J Surg 2018 Mar;215(3):467-470. Epub 2018 Feb 2 doi: 10.1016/j.amjsurg.2017.11.022. PMID: 29395023

Diagnosis

Establishment and external validation of prognosis prediction nomogram for patients with distant metastatic intrahepatic cholangiocarcinoma: based on a large population.
Yuan C, Zou S, Wang K, Hu Z
BMC Cancer 2024 Feb 16;24(1):227. doi: 10.1186/s12885-024-11976-6. PMID: 38365630Free PMC Article
Association of Liver-Directed Local Therapy With Overall Survival in Adults With Metastatic Intrahepatic Cholangiocarcinoma.
Sebastian NT, Tan Y, Miller ED, Williams TM, Noonan AM, Hays JL, Abdel-Misih S, Diaz DA
JAMA Netw Open 2019 Sep 4;2(9):e1911154. doi: 10.1001/jamanetworkopen.2019.11154. PMID: 31517963Free PMC Article
Collision tumor comprising metastatic cholangiocarcinoma and seminoma in an undescended testis: a case report.
Woo CG, Lee OJ, Yang Y, Kim YJ, Lee J, Son SM
J Int Med Res 2019 Nov;47(11):5809-5816. Epub 2019 Sep 9 doi: 10.1177/0300060519869448. PMID: 31495248Free PMC Article

Therapy

FDA Approval Summary: Futibatinib for Unresectable Advanced or Metastatic, Chemotherapy Refractory Intrahepatic Cholangiocarcinoma with FGFR2 Fusions or Other Rearrangements.
Gandhy SU, Casak SJ, Mushti SL, Cheng J, Subramaniam S, Zhao H, Zhao M, Bi Y, Liu G, Fan J, Adeniyi O, Charlab R, Kufrin D, Thompson MD, Jarrell K, Auth D, Lemery SJ, Pazdur R, Kluetz PG, Fashoyin-Aje LA
Clin Cancer Res 2023 Oct 13;29(20):4027-4031. doi: 10.1158/1078-0432.CCR-23-1042. PMID: 37289037Free PMC Article
A metastatic intrahepatic cholangiocarcinoma treated with programmed cell death 1 inhibitor: a case report and literature review.
Zhang J, Wu L, Liu J, Lin M
Immunotherapy 2020 Jun;12(8):555-561. Epub 2020 May 6 doi: 10.2217/imt-2019-0100. PMID: 32372672
Association of Liver-Directed Local Therapy With Overall Survival in Adults With Metastatic Intrahepatic Cholangiocarcinoma.
Sebastian NT, Tan Y, Miller ED, Williams TM, Noonan AM, Hays JL, Abdel-Misih S, Diaz DA
JAMA Netw Open 2019 Sep 4;2(9):e1911154. doi: 10.1001/jamanetworkopen.2019.11154. PMID: 31517963Free PMC Article
Is there a role for Ytrrium-90 in the treatment of unresectable and metastatic intrahepatic cholangiocarcinoma?
Shaker TM, Chung C, Varma MK, Doherty MG, Wolf AM, Chung MH, Assifi MM
Am J Surg 2018 Mar;215(3):467-470. Epub 2018 Feb 2 doi: 10.1016/j.amjsurg.2017.11.022. PMID: 29395023
FOLFIRI plus bevacizumab as a second-line therapy for metastatic intrahepatic cholangiocarcinoma.
Guion-Dusserre JF, Lorgis V, Vincent J, Bengrine L, Ghiringhelli F
World J Gastroenterol 2015 Feb 21;21(7):2096-101. doi: 10.3748/wjg.v21.i7.2096. PMID: 25717243Free PMC Article

Prognosis

Establishment and external validation of prognosis prediction nomogram for patients with distant metastatic intrahepatic cholangiocarcinoma: based on a large population.
Yuan C, Zou S, Wang K, Hu Z
BMC Cancer 2024 Feb 16;24(1):227. doi: 10.1186/s12885-024-11976-6. PMID: 38365630Free PMC Article
Transarterial chemoembolization plus lenvatinib with or without a PD-1 inhibitor for advanced and metastatic intrahepatic cholangiocarcinoma: a retrospective real-world study.
Ning Z, Xie L, Yan X, Hua Y, Shi W, Lin J, Xu L, Meng Z
Br J Radiol 2023 Oct;96(1150):20230079. Epub 2023 Sep 3 doi: 10.1259/bjr.20230079. PMID: 37660471Free PMC Article
Bone Metastases from Intrahepatic Cholangiocarcinoma Confer Worse Prognosis.
Garajová I, Gelsomino F, Salati M, Leonardi F, De Lorenzo S, Granito A, Tovoli F
Curr Oncol 2023 Feb 22;30(3):2613-2624. doi: 10.3390/curroncol30030199. PMID: 36975412Free PMC Article
Intrahepatic cholangiocarcinoma: Is there a role for liver transplantation?
Kim P, Littau M, Baker TB, Abdelsattar Z, Tonelli C, Bunn C, Kulshrestha S, Luchette FA, Baker MS
Surgery 2022 Mar;171(3):741-746. Epub 2021 Dec 8 doi: 10.1016/j.surg.2021.09.034. PMID: 34895770
Is there a role for Ytrrium-90 in the treatment of unresectable and metastatic intrahepatic cholangiocarcinoma?
Shaker TM, Chung C, Varma MK, Doherty MG, Wolf AM, Chung MH, Assifi MM
Am J Surg 2018 Mar;215(3):467-470. Epub 2018 Feb 2 doi: 10.1016/j.amjsurg.2017.11.022. PMID: 29395023

Clinical prediction guides

Establishment and external validation of prognosis prediction nomogram for patients with distant metastatic intrahepatic cholangiocarcinoma: based on a large population.
Yuan C, Zou S, Wang K, Hu Z
BMC Cancer 2024 Feb 16;24(1):227. doi: 10.1186/s12885-024-11976-6. PMID: 38365630Free PMC Article
Conditional cancer-specific survival after radical hepatectomy in patients with nonmetastatic intrahepatic cholangiocarcinoma.
Yan X, Wang L, Meng Z
Scand J Gastroenterol 2022 Apr;57(4):481-485. Epub 2022 Jan 10 doi: 10.1080/00365521.2021.2022192. PMID: 35007461
Intrahepatic cholangiocarcinoma: Is there a role for liver transplantation?
Kim P, Littau M, Baker TB, Abdelsattar Z, Tonelli C, Bunn C, Kulshrestha S, Luchette FA, Baker MS
Surgery 2022 Mar;171(3):741-746. Epub 2021 Dec 8 doi: 10.1016/j.surg.2021.09.034. PMID: 34895770
Association of Liver-Directed Local Therapy With Overall Survival in Adults With Metastatic Intrahepatic Cholangiocarcinoma.
Sebastian NT, Tan Y, Miller ED, Williams TM, Noonan AM, Hays JL, Abdel-Misih S, Diaz DA
JAMA Netw Open 2019 Sep 4;2(9):e1911154. doi: 10.1001/jamanetworkopen.2019.11154. PMID: 31517963Free PMC Article
FOLFIRI plus bevacizumab as a second-line therapy for metastatic intrahepatic cholangiocarcinoma.
Guion-Dusserre JF, Lorgis V, Vincent J, Bengrine L, Ghiringhelli F
World J Gastroenterol 2015 Feb 21;21(7):2096-101. doi: 10.3748/wjg.v21.i7.2096. PMID: 25717243Free PMC Article

Recent systematic reviews

Locoregional therapy combined with systemic therapy (LRT + ST) for unresectable and metastatic intrahepatic cholangiocarcinoma: a systematic review and meta-analysis.
Zhang M, Qi W, Qiu X, Yu C, Qiu W, Wang S, Qiu Z
Radiol Oncol 2023 Dec 1;57(4):419-429. Epub 2023 Nov 30 doi: 10.2478/raon-2023-0059. PMID: 38038416Free PMC Article

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