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Abnormal pulmonary alveolar system morphology

MedGen UID:
1773274
Concept ID:
C5421634
Anatomical Abnormality
HPO: HP:0033137

Definition

A structural abnormality of the pulmonary acinus, alveolar parenchyma, or alveoli. [from HPO]

Recent clinical studies

Etiology

Doktor F, Antounians L, Lacher M, Zani A
Semin Pediatr Surg 2022 Dec;31(6):151228. Epub 2022 Nov 16 doi: 10.1016/j.sempedsurg.2022.151228. PMID: 36442455
Chieng HC, Ibrahim A, Chong WH, Freed H, Fabian T, Saha B, Foulke L, Chopra A
Am J Med Sci 2022 May;363(5):452-455. Epub 2022 Feb 5 doi: 10.1016/j.amjms.2022.01.019. PMID: 35134372
Oh SH, Kim CY, Lee BS, Kim DK, Kim EA, Kim KS
Pediatr Pulmonol 2017 Dec;52(12):1572-1577. Epub 2017 Oct 13 doi: 10.1002/ppul.23835. PMID: 29028157
Tselios K, Urowitz MB
Curr Rheumatol Rev 2017;13(3):206-218. doi: 10.2174/1573397113666170704102444. PMID: 28675998
Bai TR, Knight DA
Clin Sci (Lond) 2005 Jun;108(6):463-77. doi: 10.1042/CS20040342. PMID: 15896192

Diagnosis

Nagamoto K, Maruyama H, Ishuguro A, Ito Y
BMJ Case Rep 2024 Sep 12;17(9) doi: 10.1136/bcr-2024-261004. PMID: 39266041
Doktor F, Antounians L, Lacher M, Zani A
Semin Pediatr Surg 2022 Dec;31(6):151228. Epub 2022 Nov 16 doi: 10.1016/j.sempedsurg.2022.151228. PMID: 36442455
Tselios K, Urowitz MB
Curr Rheumatol Rev 2017;13(3):206-218. doi: 10.2174/1573397113666170704102444. PMID: 28675998
Szafranski P, Gambin T, Dharmadhikari AV, Akdemir KC, Jhangiani SN, Schuette J, Godiwala N, Yatsenko SA, Sebastian J, Madan-Khetarpal S, Surti U, Abellar RG, Bateman DA, Wilson AL, Markham MH, Slamon J, Santos-Simarro F, Palomares M, Nevado J, Lapunzina P, Chung BH, Wong WL, Chu YWY, Mok GTK, Kerem E, Reiter J, Ambalavanan N, Anderson SA, Kelly DR, Shieh J, Rosenthal TC, Scheible K, Steiner L, Iqbal MA, McKinnon ML, Hamilton SJ, Schlade-Bartusiak K, English D, Hendson G, Roeder ER, DeNapoli TS, Littlejohn RO, Wolff DJ, Wagner CL, Yeung A, Francis D, Fiorino EK, Edelman M, Fox J, Hayes DA, Janssens S, De Baere E, Menten B, Loccufier A, Vanwalleghem L, Moerman P, Sznajer Y, Lay AS, Kussmann JL, Chawla J, Payton DJ, Phillips GE, Brosens E, Tibboel D, de Klein A, Maystadt I, Fisher R, Sebire N, Male A, Chopra M, Pinner J, Malcolm G, Peters G, Arbuckle S, Lees M, Mead Z, Quarrell O, Sayers R, Owens M, Shaw-Smith C, Lioy J, McKay E, de Leeuw N, Feenstra I, Spruijt L, Elmslie F, Thiruchelvam T, Bacino CA, Langston C, Lupski JR, Sen P, Popek E, Stankiewicz P
Hum Genet 2016 May;135(5):569-586. Epub 2016 Apr 12 doi: 10.1007/s00439-016-1655-9. PMID: 27071622Free PMC Article
Belloli EA, Beckford R, Hadley R, Flaherty KR
Respirology 2016 Feb;21(2):259-68. Epub 2015 Nov 13 doi: 10.1111/resp.12674. PMID: 26564810

Therapy

Tunoğlu S, Tutar L, Gümüş M, Tunoğlu ENY, Koca İ, Tutar Y
Chem Biodivers 2024 Feb;21(2):e202301422. Epub 2024 Jan 10 doi: 10.1002/cbdv.202301422. PMID: 38156745
Casey DT, Bou Jawde S, Herrmann J, Mori V, Mahoney JM, Suki B, Bates JHT
Sci Rep 2021 Aug 17;11(1):16654. doi: 10.1038/s41598-021-95911-w. PMID: 34404841Free PMC Article
Kligerman S, Raptis C, Larsen B, Henry TS, Caporale A, Tazelaar H, Schiebler ML, Wehrli FW, Klein JS, Kanne J
Radiology 2020 Mar;294(3):491-505. Epub 2020 Jan 28 doi: 10.1148/radiol.2020192585. PMID: 31990264
Oh SH, Kim CY, Lee BS, Kim DK, Kim EA, Kim KS
Pediatr Pulmonol 2017 Dec;52(12):1572-1577. Epub 2017 Oct 13 doi: 10.1002/ppul.23835. PMID: 29028157
Wright JL, Churg A
Br J Ind Med 1985 Aug;42(8):556-9. doi: 10.1136/oem.42.8.556. PMID: 2990526Free PMC Article

Prognosis

Nagamoto K, Maruyama H, Ishuguro A, Ito Y
BMJ Case Rep 2024 Sep 12;17(9) doi: 10.1136/bcr-2024-261004. PMID: 39266041
Planté-Bordeneuve T, Pilette C, Froidure A
Front Immunol 2021;12:631235. Epub 2021 May 19 doi: 10.3389/fimmu.2021.631235. PMID: 34093523Free PMC Article
Tselios K, Urowitz MB
Curr Rheumatol Rev 2017;13(3):206-218. doi: 10.2174/1573397113666170704102444. PMID: 28675998
Belloli EA, Beckford R, Hadley R, Flaherty KR
Respirology 2016 Feb;21(2):259-68. Epub 2015 Nov 13 doi: 10.1111/resp.12674. PMID: 26564810
Hohlfeld JM, Tiryaki E, Hamm H, Hoymann HG, Krug N, Haverich A, Fabel H
Am J Respir Crit Care Med 1998 Sep;158(3):706-12. doi: 10.1164/ajrccm.158.3.9708063. PMID: 9730994

Clinical prediction guides

Schruf E, Schroeder V, Le HQ, Schönberger T, Raedel D, Stewart EL, Fundel-Clemens K, Bluhmki T, Weigle S, Schuler M, Thomas MJ, Heilker R, Webster MJ, Dass M, Frick M, Stierstorfer B, Quast K, Garnett JP
FASEB J 2020 Jun;34(6):7825-7846. Epub 2020 Apr 16 doi: 10.1096/fj.201902926R. PMID: 32297676
Szafranski P, Gambin T, Dharmadhikari AV, Akdemir KC, Jhangiani SN, Schuette J, Godiwala N, Yatsenko SA, Sebastian J, Madan-Khetarpal S, Surti U, Abellar RG, Bateman DA, Wilson AL, Markham MH, Slamon J, Santos-Simarro F, Palomares M, Nevado J, Lapunzina P, Chung BH, Wong WL, Chu YWY, Mok GTK, Kerem E, Reiter J, Ambalavanan N, Anderson SA, Kelly DR, Shieh J, Rosenthal TC, Scheible K, Steiner L, Iqbal MA, McKinnon ML, Hamilton SJ, Schlade-Bartusiak K, English D, Hendson G, Roeder ER, DeNapoli TS, Littlejohn RO, Wolff DJ, Wagner CL, Yeung A, Francis D, Fiorino EK, Edelman M, Fox J, Hayes DA, Janssens S, De Baere E, Menten B, Loccufier A, Vanwalleghem L, Moerman P, Sznajer Y, Lay AS, Kussmann JL, Chawla J, Payton DJ, Phillips GE, Brosens E, Tibboel D, de Klein A, Maystadt I, Fisher R, Sebire N, Male A, Chopra M, Pinner J, Malcolm G, Peters G, Arbuckle S, Lees M, Mead Z, Quarrell O, Sayers R, Owens M, Shaw-Smith C, Lioy J, McKay E, de Leeuw N, Feenstra I, Spruijt L, Elmslie F, Thiruchelvam T, Bacino CA, Langston C, Lupski JR, Sen P, Popek E, Stankiewicz P
Hum Genet 2016 May;135(5):569-586. Epub 2016 Apr 12 doi: 10.1007/s00439-016-1655-9. PMID: 27071622Free PMC Article
Yamada T, Uehara K, Kawanishi R, Mizutani T, Sunagawa K, Araya J, Kawabata Y
Histopathology 2006 Jun;48(7):846-54. doi: 10.1111/j.1365-2559.2006.02445.x. PMID: 16722934
Nakata M, Sase M, Anno K, Sumie M, Hasegawa K, Nakamura Y, Kato H
Early Hum Dev 2003 May;72(1):75-81. doi: 10.1016/s0378-3782(03)00026-4. PMID: 12706314
Wright JL, Churg A
Br J Ind Med 1985 Aug;42(8):556-9. doi: 10.1136/oem.42.8.556. PMID: 2990526Free PMC Article

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